141. Use of plasma nitriding to improve the wear and corrosion resistance of 18Ni-300 maraging steel manufactured by selective laser meltingMatjaž Godec, Bojan Podgornik, Aleksandra Kocijan, Črtomir Donik, Danijela Anica Skobir Balantič, 2021, original scientific article Keywords: selective laser melting, 18Ni-300 maraging steel, heat treatment, plasma nitriding, retained and reverted austenite, wear and corrosion behaviour
Published in DiRROS: 25.03.2024; Views: 85; Downloads: 49
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142. Pedunculate oak (Quercus robur L.) in Bosnia and Herzegovina - state and perspectivesMirzeta Memišević Hodžić, Dalibor Ballian, 2023, original scientific article Abstract: Bosnia and Herzegovina is located in Southeast Europe, and more than half its area of 51.129 km² belongs to forests and forest lands. 93% of the forests of Bosnia and Herzegovina are natural forests and have many plant species, many of which are endemic. There are eight oak species growing in Bosnia and Herzegovina. The most important ones are Quercus robur (despite being almost extinct due to overexploitation during the late XIX and early XX century), and Quercus petraea. Pedunculate oak in Bosnia and Herzegovina is found in mixed stands with common hornbeam and in pure stands under exceptional conditions, with a total area of about 30,000 ha. In this paper, the data of the studies carried out in the pedunculate oak forests of Bosnia and Herzegovina were compiled and a general evaluation was made. The results of phenological observation in pedunculate oak provenance test in Bosnia and Herzegovina through the years showed statistically significant differences among provenances in the beginning, end and duration of individual phenological phases. Researches on growth showed overtaking of provenances through the years, and best results in provenance Jelah for the most of investigated years. The research results on showed a significant positive correlation between the height and root collar diameter in provenance test and most of the investigated .The remaining pedunculate oak populations in Bosnia and Herzegovina have a good genetic structure and can be used as a seed stands for collecting seed material and producing seedlings for afforestation with this species
Keywords: Pedunculate oak, Bosnia and Herzegovina, afforestation
Published in DiRROS: 25.03.2024; Views: 67; Downloads: 48
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143. How does day-to-day stress appraisal relate to coping among office workers in academia? : an ecological momentary assessment studyStephanie Hulin, Larissa Bolliger, Junoš Lukan, Anneleen Caluwaerts, Rosalie De Neve, Mitja Luštrek, Dirk De Bacquer, Els Clays, 2023, original scientific article Abstract: Existing literature indicates that academic staff experience increasing levels of work stress. This study investigated associations between day-to-day threat and challenge appraisal and day-to-day problem-focused coping, emotion-focused coping, and seeking social support among academic office workers. This study is based on an Ecological Momentary Assessment (EMA) design with a 15-working day data collection period utilising our self-developed STRAW smartphone application. A total of 55 office workers from academic institutions in Belgium (n = 29) and Slovenia (n = 26) were included and 3665 item measurements were analysed. Participants were asked approximately every 90 min about their appraisal of stressful events (experienced during the working day) and their coping styles. For data analysis, we used an unstructured covariance matrix in our linear mixed models. Challenge appraisal predicted problem-focused coping and threat appraisal predicted emotion-focused coping. Our findings suggest an association between threat appraisal as well as challenge appraisal and seeking social support. Younger and female workers chose social support more often as a coping style. While working from home, participants were less likely to seek social support. The findings of our EMA study confirm previous research on the relationship between stress appraisal and coping with stress. Participants reported seeking social support less while working from home compared to working at the office, making the work location an aspect that deserves further research.
Keywords: academic setting, coping, work stress
Published in DiRROS: 25.03.2024; Views: 73; Downloads: 14
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144. Hardware–software co-design of an audio feature extraction pipeline for machine learning applicationsJure Vreča, Ratko Pilipović, Anton Biasizzo, 2024, original scientific article Abstract: Keyword spotting is an important part of modern speech recognition pipelines. Typical contemporary keyword-spotting systems are based on Mel-Frequency Cepstral Coefficient (MFCC) audio features, which are relatively complex to compute. Considering the always-on nature of many keyword-spotting systems, it is prudent to optimize this part of the detection pipeline. We explore the simplifications of the MFCC audio features and derive a simplified version that can be more easily used in embedded applications. Additionally, we implement a hardware generator that generates an appropriate hardware pipeline for the simplified audio feature extraction. Using Chisel4ml framework, we integrate hardware generators into Python-based Keras framework, which facilitates the training process of the machine learning models using our simplified audio features.
Keywords: FPGA, MFCC, keyword spotting, chisel
Published in DiRROS: 25.03.2024; Views: 82; Downloads: 41
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146. MicroRNAs and long non-coding RNAs : prospects in diagnostics and therapy of cancerNina Hauptman, Damjan Glavač, 2013, published scientific conference contribution Abstract: Background. Non-coding RNAs (ncRNAs) are key regulatory molecules in cellular processes, and are potentialbiomarkers in many diseases. Currently, microRNAs and long non-coding RNAs are being pursued as diagnostic andprognostic biomarkers, and as therapeutic tools in cancer, since their expression profiling is able to distinguish differentcancer types and classify their sub-types.Conclusions. There are numerous studies confirming involvement of ncRNAs in cancer initiation, development andprogression, but have only been recently identified as new diagnostic and prognostic tools. This can be beneficialin future medical cancer treatment options, since ncRNAs are natural antisense interactors included in regulationof many genes connected to survival and proliferation. Research is directed in development of useful markers fordiagnosis and prognosis in cancer and in developing new RNA-based cancer therapies, of which some are alreadyin clinical trials.
Keywords: microRNAs, long non-coding RNAs, biomarker
Published in DiRROS: 22.03.2024; Views: 67; Downloads: 33
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147. Recombinant human erythropoietin alters gene expression and stimulates proliferation of MCF-7 breast cancer cellsNina Trošt, Tina Stepišnik, Sabina Berne, Anja Pucer Janež, Toni Petan, Radovan Komel, Nataša Debeljak, 2013, published scientific conference contribution Abstract: Background. Functional erythropoietin (EPO) signaling is not specific only to erythroid lineages and has been confirmed in several solid tumors, including breast. Three different isoforms of erythropoietin receptor (EPOR) have been reported, the soluble (EPOR-S) and truncated (EPOR-T) forms acting antagonistically to the functional EPOR. In this study, we investigated the effect of human recombinant erythropoietin (rHuEPO) on cell proliferation, early gene response and the expression of EPOR isoforms in the MCF-7 breast cancer cell line.Materials and methods. The MCF-7 cells were cultured with or without rHuEPO for 72 h or 10 weeks and assessed for their growth characteristics, expression of early response genes and different EPOR isoforms. The expression profile of EPOR and EPOR-T was determined in a range of breast cancer cell lines and compared with their invasive properties.Results. MCF-7 cell proliferation after rHuEPO treatment was dependent on the time of treatment and the concentration used. High rHuEPO concentrations (40 U/ml) stimulated cell proliferation independently of a preceding long-term exposure of MCF-7 cells to rHuEPO, while lower concentrations increased MCF-7 proliferation only after 10 weeks of treatment. Gene expression analysis showed activation of EGR1 and FOS, confirming the functionality of EPOR. rHuEPO treatment also slightly increased the expression of the functional EPOR isoform, which, however, persisted throughout the 10 weeks of treatment. The expression levels of EPOR-T were not influenced. There were no correlations between EPOR expression and the invasiveness of MCF-7, MDA-MB-231, Hs578T, Hs578Bst, SKBR3, T-47D and MCF-10A cell lines.Conclusions. rHuEPO modulates MCF-7 cell proliferation in time- and concentration-dependent manner. We confirmed EGR1, FOS and EPOR as transcription targets of the EPO-EPOR signaling loop, but could not correlate the expression of different EPOR isoforms with the invasiveness of breast cancer cell lines.
Keywords: breast cancer, erythropoietin, gene expression
Published in DiRROS: 22.03.2024; Views: 100; Downloads: 40
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148. Inhibition of cathepsin X enzyme influences the immune response of THP-1 cells and dendritic cells infected with Helicobacter pyloriMiha Skvarč, David Štubljar, Andreja Nataša Kopitar, Samo Jeverica, Bojan Tepeš, Janko Kos, Alojz Ihan, 2013, original scientific article Abstract: Background. The immune response to Helicobacter pylori importantly determines the outcome of infection as well as the success of eradication therapy. We demonstrate the role of a cysteine protease cathepsin X in the immune response to H. pylori infection. Materials and methods. We analysed how the inhibition of cathepsin X influenced the immune response in experiments when THP-1 cells or dendritic cells isolated from patients were stimulated with 48 strains of H. pylori isolated from gastric biopsy samples of patients which had problems with the eradication of bacteria. Results. The experiments, performed with the help of a flow cytometer, showed that the expression of Toll-like receptors (TLRs), especially TLR-4 molecules, on the membranes of THP-1 cells or dendritic cells was higher when we stimulated cells with H. pylori together with inhibitor of cathepsin X 2F12 compared to THP-1 cells or dendritic cells stimulated with H. pylori only, and also in comparison with negative control samples. We also demonstrated that when we inhibited the action of cathepsin X in THP-1 cells, the concentrations of pro-inflammatory cytokines were lower than when THP-1 cell were stimulated with H. pylori only. Conclusions. We demonstrated that inhibition of cathepsin X influences the internalization of TLR-2 and TLR-4. TLR-2 and TLR-4 redistribution to intra-cytoplasmic compartments is hampered if cathepsin X is blocked. The beginning of a successful immune response against H. pylori in the case of cathepsin X inhibition is delayed.
Keywords: cathepsin X, macrophage, dendritic cells
Published in DiRROS: 22.03.2024; Views: 73; Downloads: 40
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149. Development and characterization of a novel mAb against bilitranslocase - a new biomarker of renal carcinomaSendi Montanič, Michela Terdoslavich, Uroš Rajčević, Luigina De Leo, Serena Bonin, Vladka Čurin-Šerbec, Sabina Passamonti, 2013, original scientific article Keywords: bilitranslocase, monoclonal antibody, peptide antigen
Published in DiRROS: 22.03.2024; Views: 79; Downloads: 31
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