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Ključne besede: športniki, vadba, intenzivna vadba, bolečine, hiperbarična terapija, radijsko frekvenčna terapija
Objavljeno v DiRROS: 12.11.2021; Ogledov: 1116; Prenosov: 279
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Povzetek: Although autonomic nervous system (ANS) dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) has been proposed, conflicting evidence makes it difficult to draw firm conclusions regarding ANS activity at rest in ME/CFS patients. Although severe exercise intolerance is one of the core features of ME/CFS, little attempts have been made to study ANS responses to physical exercise. Therefore, impairments in ANS activation at rest and following exercise were examined using a case-control study in 20 ME/CFS patients and 20 healthy people. Different autonomous variables, including cardiac, respiratory, and electrodermal responses were assessed at rest and following an acute exercise bout. At rest, parameters in the time-domain represented normal autonomic function in ME/CFS, while frequency-domain parameters indicated the possible presence of diminished (para)sympathetic activation. Reduced parasympathetic reactivation during recovery from exercise was observed in ME/CFS. This is the first study showing reduced parasympathetic reactivation during recovery from physical exercise in ME/CFS. Delayed HR recovery and/or a reduced HRV as seen in ME/CFS have been associated with poor disease prognosis, high risk for adverse cardiac events, and morbidity in other pathologies, implying that future studies should examine whether this is also the case in ME/CFS and how to safely improve HR recovery in this population.
Ključne besede: autonomic nervous system, autonomic function, electrodermal activity, electrocardiogram, heart rate, physical activity
Objavljeno v DiRROS: 20.10.2021; Ogledov: 887; Prenosov: 766
Celotno besedilo (4,50 MB)
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Povzetek: Background: Maintaining skeletal muscle mass and function in aging is crucial for preserving the quality of life and health. An experimental bed rest (BR) protocol is a suitable model to explore muscle decline on aging during inactivity. Objective: The purpose of this systematic review and meta-analysis was, therefore, to carry out an up-to-date evaluation of bed rest, with a specific focus on the magnitude of effects on muscle mass, strength, power, and functional capacity changes as well as the mechanisms, molecules, and pathways involved in muscle decay. Design: This was a systematic review and meta-analysis study. Data sources: We used PubMed, Medline; Web of Science, Google Scholar, and the Cochrane library, all of which were searched prior to April 23, 2020. A manual search was performed to cover bed rest experimental protocols using the following key terms, either singly or in combination: %Elderly Bed rest,% %Older Bed rest,% %Old Bed rest,% %Aging Bed rest,% %Aging Bed rest,% %Bed-rest,% and %Bedrest%. Eligibility criteria for selecting studies: The inclusion criteria were divided into four sections: type of study, participants, interventions, and outcome measures. The primary outcome measures were: body mass index, fat mass, fat-free mass, leg lean mass, cross-sectional area, knee extension power, cytokine pattern, IGF signaling biomarkers, FOXO signaling biomarkers, mitochondrial modulation biomarkers, and muscle protein kinetics biomarkers. Results: A total of 25 studies were included in the qualitative synthesis, while 17 of them were included in the meta-analysis. In total, 118 healthy elderly volunteers underwent 5-, 7-, 10-, or 14-days of BR and provided a brief sketch on the possible mechanisms involved. In the very early phase of BR, important changes occurred in the skeletal muscle, with significant loss of performance associated with a lesser grade reduction of the total body and muscle mass. Meta-analysis of the effect of bed rest on total body mass was determined to be small but statistically significant (ES = %0.45, 95% CI: %0.72 to %0.19, P < 0.001). Moderate, statistically significant effects were observed for total lean body mass (ES = %0.67, 95% CI: %0.95 to %0.40, P < 0.001) after bed rest intervention. Overall, total lean body mass was decreased by 1.5 kg, while there was no relationship between bed rest duration and outcomes (Z = 0.423, p = 672). The meta-analyzed effect showed that bed rest produced large, statistically significant, effects (ES = %1.06, 95% CI: %1.37 to %0.75, P < 0.001) in terms of the knee extension power. Knee extension power was decreased by 14.65 N/s. In contrast, to other measures, meta-regression showed a significant relationship between bed rest duration and knee extension power (Z = 4.219, p < 0.001). Moderate, statistically significant, effects were observed after bed rest intervention for leg muscle mass in both old (ES = %0.68, 95% CI: %0.96 to %0.40, P < 0.001) and young (ES = %0.51, 95% CI: %0.80 to %0.22, P < 0.001) adults. However, the magnitude of change was higher in older (MD = %0.86 kg) compared to younger (MD = %0.24 kg) adults. Conclusion: Experimental BR is a suitable model to explore the detrimental effects of inactivity in young adults, old adults, and hospitalized people. Changes in muscle mass and function are the two most investigated variables, and they allow for a consistent trend in the BR-induced changes. Mechanisms underlying the greater loss of muscle mass and function in aging, following inactivity, need to be thoroughly investigated.
Ključne besede: bed rest, aging, muscles, muscle physiopathology, muscle function
Objavljeno v DiRROS: 26.08.2021; Ogledov: 1729; Prenosov: 930
Celotno besedilo (1,32 MB)
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Povzetek: Based on Yugoslav archival sources, the paper analyses the relationship between the Holy See and Yugoslavia as the only Eastern European socialist state with which the former had official diplomatic relations. The relationship between the Holy See and socialist Yugoslavia provides insight into the precarious position of the Catholic Church in Yugoslavia, but also into the issues and dilemmas that the Holy See faced in terms of its Ostpolitik towards Eastern European socialist regimes. The article initially centres on the parallels between the Holy See and the foreign policy agenda of non-aligned Yugoslavia, especially during the papacy of Paul VI, when both actors shared an understanding of the acute problems of the Global South. It then analyses the stance of the Holy See towards the Yugoslav domestic policy of self-management that claimed that this system could present a viable environment for the life of believers in modern socialist society. The analysis closes with an in-depth examination of the role of the Holy See in the process of convergence between religion and nationalism during the 1980s, in which the Vatican did not play as clear-cut a role as it has generally been ascribed and proved unable to tackle this formidable phenomenon.
Ključne besede: Yugoslavia, Vatican, Roman catholic church, church and state, relations
Objavljeno v DiRROS: 19.07.2021; Ogledov: 892; Prenosov: 804
Celotno besedilo (1,58 MB)
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Povzetek: Medreligijski dialog je v Evropi na eni strani bolj razvit in dinamičen kot kdaj koli prej, na drugi strani pa so medverski odnosi z vzponom nacionalizmov in v senci begunske krize ter pandemije COVID-19 pod močnim pritiskom in so žrtve grobe politizacije. Kritično razumevanje dinamike in različnih kontekstov medreligijskega dialoga ter ovir za takšen dialog je ključnega pomena za opredelitev najboljših možnosti za uspeh dialoga in omogočanje sobivanja v religijski pluralnosti. Zbornik vsebuje povzetke referatov na mednarodnem simpoziju "Religious peace-building, inter-religious dialogue, migrations and refugee crisis/Religijska izgradnja miru, medreligijski dialog, migracije in begunska kriza", katerih osrednji poudarek je iskanje novih paradigem, modelov in možnosti za medreligijski dialog ter iskanje novih etičnih meril in teoloških odzivov na begunsko in pandemično krizo. Obenem se simpozij usmerja v povezovanje teh spoznanj z novo etiko religijske izgradnje miru v luči medsebojne soodvisnosti in kohezije ter ponovnega premišljanja vloge moralnih in intelektualnih vrlin, komunikacije in pomena vključevanja ženskih glasov v okvir medreligijskega dialoga.
Ključne besede: medreligijski dialog, zborniki, elektronske knjige
Objavljeno v DiRROS: 15.07.2021; Ogledov: 935; Prenosov: 1010
Celotno besedilo (1,49 MB)
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