1. Red blood cell transfusion and skeletal muscle tissue oxygenation in anaemic haematologic outpatientsMatej Podbregar, Ana Uršula Gavrič, Eva Podbregar, Hugon Možina, Sebastian Stefanović, 2016, izvirni znanstveni članek Povzetek: Background. Stored red blood cells (RBCs) accumulate biochemical and biophysical changes, known as storage lesion. The aim of this study was to re-challenge current data that anaemia in chronically anaemic haematology patients is not associated with low skeletal muscle tissue oxygen (StO2), and that RBC storage age does not influence the tissue response after ischaemic provocation, using near-infrared spectroscopy. Patients and methods. Twenty-four chronic anaemic haematology patients were included. Thenar skeletal muscle StO2 was measured at rest (basal StO2), with vascular occlusion testing (upslope StO2, maximum StO2) before and after transfusion. Results. Basal StO2 was low (53% +- 7%). Average RBC storage time was 10.5 +- 3.9 days. Effects of RBC transfusions were as follows: basal StO2 and upslope StO2 did not change significantly; maximum StO2 increased compared to baseline (64 +- 14% vs. 59 +- 10%, p = 0.049). Change of basal StO2, upslope StO2 and maximum StO2 was negatively related to age of RBCs. The decrease of maximum StO2 was predicted (sensitivity 70%, specificity 100%), after receiving RBCs >- 10days old. Discussion. Resting skeletal muscle StO2 in chronic anaemic patients is low. RBC storage time affects skeletal muscle StO2 in the resting period and after ischaemic provocation. Ključne besede: skeletal muscle, transfusion, red blood cells Objavljeno v DiRROS: 09.05.2024; Ogledov: 68; Prenosov: 45 Celotno besedilo (958,31 KB) Gradivo ima več datotek! Več... |
2. The role of neoadjuvant chemotherapy in patients with advanced (stage IIIC) epithelial ovarian cancerErik Škof, Sebastjan Merlo, Gašper Pilko, Borut Kobal, 2016, izvirni znanstveni članek Povzetek: Primary treatment of patients with advanced epithelial ovarian cancer consists of chemotherapy either before (neoadjuvant chemotherapy, NACT) or after primary surgery (adjuvant chemotherapy). The goal of primary treatment is no residual disease after surgery (R0 resection) what is associated with an improvement in survival of patients. There is, however, no evidence of survival benefits in patients with R0 resections after prior NACT. Methods. We retrospectively reviewed the records of patients who were treated with diagnosis of epithelial ovarian cancer at Institute of Oncology Ljubljana in the years 2005%2007. The differences in the rates of R0 resections, progression free survival (PFS), overall survival (OS) and in five-year and eight-year survival rates between patients treated with NACT and patients who had primary surgery were compared. Results. Overall 160 patients had stage IIIC epithelial ovarian cancer. Eighty patients had NACT and eighty patients had primary surgery. Patients in NACT group had higher rates of R0 resection (42% vs. 20%; p = 0.011) than patients after primary surgery. PFS was 14.1 months in NACT group and 17.7 months after primary surgery (p = 0.213). OS was 24.8 months in NACT group and 31.6 months after primary surgery (p = 0.012). In patients with R0 resections five-year and eight-year survival rates were 20.6% and 17.6% in NACT group compared to 62.5% and 62.5% after primary surgery (p < 0.0001), respectively. Conclusions. Despite higher rates of R0 resections achieved by NACT, survival of patients treated with NACT was inferior to survival of patients who underwent primary surgery. NACT should only be offered to patients with advanced epithelial cancer who are not candidates for primary surgery. Ključne besede: ovarian cancer, advanced ovarian cancer, neoadjuvant chemotherapy, primary surgery Objavljeno v DiRROS: 30.04.2024; Ogledov: 107; Prenosov: 28 Celotno besedilo (597,52 KB) |
3. Optimal scan time for evaluation of parathyroid adenoma with [18F]-fluorocholine PET/CTSebastijan Rep, Luka Ležaič, Tomaž Kocjan, Marija Pfeifer, Mojca Jensterle Sever, Urban Simončič, Petra Tomše, Marko Hočevar, 2015, izvirni znanstveni članek Ključne besede: lesions representing enlarged parathyroid tissue, triple-phase, standardized uptake value, retention index, lesion contrast, rak (medicina), obščitnični adenomi, diagnostika Objavljeno v DiRROS: 22.04.2024; Ogledov: 209; Prenosov: 247 Celotno besedilo (850,44 KB) Gradivo ima več datotek! Več... |
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5. An outbreak of Verticillium dahliae on sycamore maple in a forest stand in SloveniaAna Brglez, Zina Devetak, Nikica Ogris, Sebastjan Radišek, Barbara Piškur, 2024, izvirni znanstveni članek Povzetek: Verticillium dahliae Kleb., the causal agent of Verticillium wilts, is a devastating plant disease affecting many plant species. Fungus V. dahliae was detected in a partially artificially established Acer pseudoplatanus L. forest stand in central Slovenia. This finding incited further study about the risk of different sources of V. dahliae isolates for maples in forests and the pathogenicity of three V. dahliae isolates of different origins was tested on saplings of A. pseudoplatanus, A. platanoides L., and A. campestre L. The inoculated saplings exhibited disease symptoms, i.e., leaf necrosis and wilting. At the end of the pathogenicity test, typical xylem browning was visible on the cross-sections, and the pathogen was successfully re-isolated. The isolates showed significant differences in their pathogenicity to specific maple hosts, with the agricultural isolate (originated from bell pepper) being the most aggressive on all three maple species. The disease severity index (DSI) and relative area under the disease progress curve (rAUDPC), as well as the success of re-isolation, indicate that A. platanoides is the most susceptible to inoculation with V. dahliae. In addition, significant differences in sapling biomass were observed between treated and control plants. These results suggest that maples in forest stands are threatened by V. dahliae, and biosecurity measures should be considered and implemented in forest management to reduce the transmission and potential spread of the pathogen. Ključne besede: Verticillium wilt, Acer spp., pathogenicity test, Disease severity index, DSI, Area under the disease progress curve, AUDPC, biosecurity Objavljeno v DiRROS: 07.02.2024; Ogledov: 285; Prenosov: 242 Celotno besedilo (1,75 MB) Gradivo ima več datotek! Več... |
6. Vsakodnevna kontrola kakovosti mamografijUrban Zdešar, Sebastjan Korat, Zvonko Krajnc, 2001, objavljeni strokovni prispevek na konferenci Povzetek: Preverjanje kakovosti v mamografiji, kot ga poznajo razvite države, je v Sloveniji šele na začetku. Gre za preproste meritve, s katerimi določamo vrednosti parametrov, ki vplivajo na kakovost mamografskih slik in dozo. Prispevek opisuje zasnovo programa preverjanja kakovosti, ki ga izvajajo na radiološkem oddelku Onkološkega inštituta v Ljubljani. Prvi rezultati programabodo pomagali predvsem razumeti razliko med normalnim spreminjanjem delovanja opreme in večjimi neujemanji in trendi. Prav pravočasno zaznavanje takšnih sprememb je glavni namen preverjanja kakovosti. Objavljeno v DiRROS: 30.11.2023; Ogledov: 236; Prenosov: 67 Celotno besedilo (454,67 KB) |
7. Naše izkušnje z dnevno kontrolo razvijanja filmovGregor Novak, Zvonko Kranjc, Sebastjan Korat, 2001, objavljeni strokovni prispevek na konferenci Povzetek: Izvajanje kontrole kakovosti se je na Onkološkem inštitutu začelo z letom 2000. Njen namen je bil dvigniti raven obdelave filmov in odkriti napake v obdelavi filmov še preden bi te utegnile pomembneje vplivati na kakovost mamogramov. V naslednjem sestavku je na kratko opisan postopek določitve počrnitvene krivulje in parametrov s katerimi dnevno spremljamo kakovost obdelave filmov. Priložena je tudi tabela s pomočjo katere lahko prepoznamo vzroke morebitnih sprememb in jih odpravimo. Objavljeno v DiRROS: 30.11.2023; Ogledov: 239; Prenosov: 60 Celotno besedilo (256,76 KB) |
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9. Rak jajčnikov : ponovno nekaj novega2023, zbornik recenziranih znanstvenih prispevkov na domači konferenci Povzetek: Rak jajčnikov je najpogostejši vzrok smrti pri ženskah, ki zbolijo za ginekološkimi raki, saj je bolezen za večino bolnic v napredovalih fazah pogosto usodna. To je posledica težavne prepoznavnosti bolezni v zgodnjih fazah, ko je zdravljenje učinkovito. /// Na žalost preventivni program za zgodnje odkrivanje raka jajčnikov še ne obstaja, zato je pri več kot 75 % bolnic bolezen odkrita v napredovalih stadijih, kar posledično prinaša slabo prognozo. Tako pri zdravnikih kot pri ženskah je pomanjkljivo poznavanje zgodnjih znakov bolezni, kar lahko vodi v napačno diagnostiko in triažiranje bolnic v neprimerno zdravstveno ustanovo. /// Diagnoza se postavi s pomočjo ustreznih diagnostičnih preiskav, potrdi pa se s patohistološko preiskavo. 90 % rakov jajčnikov izvira iz epitelija, medtem ko so drugi tipi redki. Osnovno zdravljenje vključuje kirurški poseg, katerega cilj je popolnoma odstraniti bolezen in doseči stanje brez vidnega ostanka bolezni. Sledi sistemska terapija, medtem ko obsevanje pri zdravljenju raka jajčnikov nima ključnega pomena. /// Ugotovljeno je, da je zdravljenje raka jajčnikov najuspešnejše v specializiranih ustanovah, kjer delujejo strokovnjaki z usmerjenostjo v ginekološko-onkološko področje. V Sloveniji si nenehno prizadevamo za standardizirano in kakovostno obravnavo žensk z rakom jajčnikov. Ključne besede: ginekološki raki, elektronske knjige Objavljeno v DiRROS: 22.11.2023; Ogledov: 339; Prenosov: 154 Celotno besedilo (1,10 MB) Gradivo ima več datotek! Več... |
10. Digital twins and road construction using secondary raw materialsSebastjan Meža, Alenka Mauko Pranjić, Rok Vezočnik, Igor Osmokrović, Stanislav Lenart, 2021, izvirni znanstveni članek Povzetek: Secondary raw materials (SRMs) tend to be a valuable replacement for finite virgin materials especially since construction works (i.e., building and civil engineering work such as road construction) require vast quantities of raw materials. Using SRM originating from recycling a broad range of inorganic waste materials (e.g., mining waste, different industrial wastes, construction, and demolition waste) has been recognized as a promising, generally more cost-efficient, and environmentally friendly alternative to the exploitation of natural resources. Despite the benefits of using SRM, several challenges need to be addressed before using SRM even more. One of them is the long-term durability and little-known response of construction works built using such alternative materials. In this paper, we present the activities to establish a fully functioning digital twin (DT) of a road constructed using SRM. The first part of the paper is devoted to the theoretical justification of efforts and ways of establishing the monitoring systems, followed by a DT case study where an integrated data environment synthesizing a Building Information Model and monitored data is presented. Although the paper builds upon a small scale, the case study is methodologically designed to allow parallels to be drawn with much larger construction projects. Ključne besede: digital twins, road construction, circular economy Objavljeno v DiRROS: 19.07.2023; Ogledov: 312; Prenosov: 202 Celotno besedilo (4,36 MB) Gradivo ima več datotek! Več... |