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Abstract: Background. Stored red blood cells (RBCs) accumulate biochemical and biophysical changes, known as storage lesion. The aim of this study was to re-challenge current data that anaemia in chronically anaemic haematology patients is not associated with low skeletal muscle tissue oxygen (StO2), and that RBC storage age does not influence the tissue response after ischaemic provocation, using near-infrared spectroscopy. Patients and methods. Twenty-four chronic anaemic haematology patients were included. Thenar skeletal muscle StO2 was measured at rest (basal StO2), with vascular occlusion testing (upslope StO2, maximum StO2) before and after transfusion. Results. Basal StO2 was low (53% +- 7%). Average RBC storage time was 10.5 +- 3.9 days. Effects of RBC transfusions were as follows: basal StO2 and upslope StO2 did not change significantly; maximum StO2 increased compared to baseline (64 +- 14% vs. 59 +- 10%, p = 0.049). Change of basal StO2, upslope StO2 and maximum StO2 was negatively related to age of RBCs. The decrease of maximum StO2 was predicted (sensitivity 70%, specificity 100%), after receiving RBCs >- 10days old. Discussion. Resting skeletal muscle StO2 in chronic anaemic patients is low. RBC storage time affects skeletal muscle StO2 in the resting period and after ischaemic provocation.
Keywords: skeletal muscle, transfusion, red blood cells
Published in DiRROS: 09.05.2024; Views: 68; Downloads: 44
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Keywords: internistična onkologija, limfom, kemoterapija
Published in DiRROS: 22.04.2024; Views: 70; Downloads: 21
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Abstract: Purpose: To assess the foot posture and hip joint mobility of elite handball and soccer players and to investigate possible correlations between these measurements. Methods: We compared the differences in means of Foot Posture Index (FPI), pas-sive hip internal (IR), and external (ER) rotation range of motion (ROM) between three groups of male subjects (17 handball players, 17 soccer players, and 16 non-athletes). The Kruskal-Walli’s test and post-hoc pairwise comparison with the Mann-Whitney U test were used to determine the differences between the group means, and associations between variables were analyzed with Spearman’s correlation coefficient. Results: No significant differences in the mean FPI were found between the soccer players (1.3 ± 2.9), handball players (0.7 ± 2.1), and the control group (1.7 ± 2.5) (p > 0.05). Similarly, no significant difference was found between the groups in the hip ER ROM. In contrast, a significantly lower (p < 0.05) hip IR ROM was observed in the soccer players (30.6° ± 5.3°) compared to the handball players (41.0° ± 8.1°) and the control group (41.1° ± 6.4°). A weak positive correlation was only observed between the FPI and hip IR ROM in the soccer players (ρ: 0.36, p = 0.035). Conclusions: Handball and soccer players show a tendency toward less pronated feet compared to non-athletes, but the differences are not significant and the mean FPI values are still within the range of normal foot posture. The range of hip IR seems to be reduced in soccer players and weakly, but significantly and positively associated with the FPI value, which needs to be further investigated in future studies.
Keywords: foot shape, hip mobility, soccer players, handball players
Published in DiRROS: 17.04.2024; Views: 113; Downloads: 54
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Abstract: Let $f$ be a noncommutative polynomial of degree $m\ge 1$ over an algebraically closed field $F$ of characteristic $0$. If $n\ge m-1$ and $\alpha_1,\alpha_2,\alpha_3$ are nonzero elements from $F$ such that $\alpha_1+\alpha_2+\alpha_3=0$, then every trace zero $n\times n$ matrix over $F$ can be written as $\alpha_1 A_1+\alpha_2A_2+\alpha_3A_3$ for some $A_i$ in the image of $f$ in $M_n(F)$.
Keywords: Waring problem, noncommutatative polynomials, matrix algebras
Published in DiRROS: 10.04.2024; Views: 100; Downloads: 43
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Abstract: Background. Colorectal cancer (CRC) is the third most common cancer in the world. In 75% CRC develops sporadically, in 25% hereditary or as a consequenceof inflammatory bowel disease. CRC carcinogenesis develops over many years. The cause of CRC in 85% is chromosomal instability (CIN) and in 15% microsatellite instability (MSI-H), where hereditary nonpolyposis colorectal cancer (HNPCC) represents 10-20%. Microsatellite sequences (MS) arerepeated sequences of short stretches of DNA all over the genome. Microsatellite stability (MSS) means MS are the same in each cell of an individual, whereas microsatellite instability (MSI-H) means MS differ in normal and cancer cells of an individual. The cause of MSI-H is a damaged mismatch repair mechanism (MMR), with the most important MMR proteins being MSH2, MLH1 and MSH6. Conclusions. MSI-H seems to be an important prognostic factor in CRC and an important predictive factor of CRC chemotherapeutic treatment efficacy. Clinical trials conducted until now have shown contradictory findings in different chemotherapeutic settings, adjuvant and palliative; therefore MSI-H is going to be the object of the future research. The future of cancer treatment is in the individualized therapy based on molecular characteristics of the tumour, such as MSI-H in CRC.
Published in DiRROS: 19.03.2024; Views: 164; Downloads: 67
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