101. Priporočila za obravnavo bolnikov z malignimi limfomiBarbara Jezeršek Novaković, Lučka Boltežar, Gorana Gašljević, Biljana Grčar-Kuzmanov, Monika Jagodic, Tanja Južnič Šetina, Veronika Kloboves-Prevodnik, Gregor Kos, Milica Miljković, Jana Pahole Goličnik, Samo Rožman, Urška Rugelj, Marija Skoblar Vidmar, Uroš Smrdel, Danijela Štrbac, Miha Toplak, Lorna Zadravec-Zaletel, Mateja Dolenc-Voljč, 2022, professional monograph Keywords: maligni limfomi, smernice, novotvorbe
Published in DiRROS: 14.03.2022; Views: 809; Downloads: 443
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102. Podobe gozdnega revirjaAnton Lesnik, Gal Fidej, Jože Prah, Jože Mori, Jože Kos, Jurij Diaci, Kristina Sever, Marija Imperl, 2022, popular article Keywords: revirni gozdar
Published in DiRROS: 08.03.2022; Views: 885; Downloads: 215
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104. Next-generation sequencing to characterize pyrazinamide resistance in Mycobacterium tuberculosis isolates from two Balkan countriesEva Sodja, Simon Koren, Nataša Toplak, Sara Truden, Marija Žolnir-Dovč, 2021, original scientific article Abstract: Objectives. Next-generation sequencing (NGS) provide a comprehensive analysis of the genetic alterations that are most commonly linked with pyrazinamide (PZA) resistance. There are no studies reporting molecular background of PZA resistance in TB isolates from Balkan Peninsula. We aimed to examine the feasibility of full-length analysis of a gene linked with PZA resistance, pncA, using Ion Torrent technology in comparison to phenotypic BACTEC MGIT 960 DST in clinical TB isolates from two countries of the Balkan Peninsula. Methods. Between 1996 and 2017, we retrospectively selected 61 TB isolates. To identify gene variants related to drug resistance in genomic DNA extracted from TB isolates, AmpliSeq libraries were generated automatically using the AmpliSeq™ Kit for Chef DL8 and the Ion AmpliSeq TB Research Panel. Result.s Of all 61 TB isolates included, 56 TB were phenotypically resistant to any antibiotic. Among them, 38/56 (67.9%) TB isolates were phenotypically resistant to pyrazinamide and pncA mutations were detected in 33/38 cases (86.8%). A mutation in the pncA promoter region was the most prevalent genetic alteration, detected in eight TB isolates. Comparison of NGS to conventional BACTEC MGIT 960 DST revealed very strong agreement (90.2%) between the two methods in identifying PZA resistance, with high sensitivity (89.5%) and specificity (95.7%) for NGS. Conclusions. Detection of PZA resistance using NGS seems to be a valuable tool for surveillance of TB drug resistance also in the Balkan Peninsula, with great potential to provide useful information at least one weak earlier than is possible with phenotypic DST.
Keywords: tuberculosis, Mycobacterium tuberculosis, high-throughput nucleotide sequencing, pyrazinamide, microbial sensitivity tests, next-generation sequencing, drug susceptibility testing, Slovenia, Republic of North Macedonia
Published in DiRROS: 10.01.2022; Views: 902; Downloads: 555
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105. Case report : congenital extrahepatic portocaval shunt presenting as pulmonary arterial hypertension in a pregnant patientMatevž Harlander, Maja Badovinac, Frosina Markoska, Barbara Salobir, Tomaž Štupnik, Marija Dolenšek, Izidor Kern, Vojka Gorjup, Nazzareno Galiè, 2022, short scientific article Abstract: Congenital extrahepatic portocaval shunt (CEPS) is a rare condition in which a rare congenital vascular anomaly of the portal system is present. CEPS may manifest as pulmonary arterial hypertension (PAH). When diagnosed and treated early, PAH can be reversible. We report a case of a previously asymptomatic woman, who manifested with severe pulmonary hypertension during pregnancy and was consequently diagnosed with CEPS. After unsuccessful medical treatment, urgent lung transplantation was done.
Keywords: pulmonary hypertension, pregnancy, congenital extrahepatic portocaval shunt, Abernethy malformation, pulmonary arterial hypertension
Published in DiRROS: 10.01.2022; Views: 798; Downloads: 458
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106. Priporočila Onkološkega inštituta za zdravljenje bolnikov z adenokarcinomom želodcaErik Brecelj, Vesna Zadnik, Neva Volk, Mateja Krajc, Ana Blatnik, Ksenija Strojnik, Nina Boc, Yasmin Marianna Hunt, Gorana Gašljević, Jera Jeruc, Srdjan Novaković, Marko Boc, Franc Anderluh, Martina Reberšek, Borut Štabuc, Irena Oblak, Janja Ocvirk, Ana Jeromen, Zvezdana Hlebanja, Tanja Mesti, Marija Ignjatović, Nežka Hribernik, Ibrahim Edhemović, Gašper Pilko, Rok Petrič, Ajra Šečerov Ermenc, Nada Rotovnik-Kozjek, Vaneja Velenik, Sonja Kramer, Maja Ebert Moltara, Jernej Benedik, 2021, professional article Keywords: adenokarcinom želodca, priporočila, prebavni trakt, multidisciplinarno zdravljenje
Published in DiRROS: 16.12.2021; Views: 1142; Downloads: 509
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107. Smrekovi podlubniki : spremljanje njihove številčnostiSimon Zidar, Andreja Kavčič, Marija Kolšek, Nikica Ogris, Maarten De Groot, 2021, other monographs and other completed works Keywords: smrekov podlubnik, režasta past, feromonska past, podlubniki, spremljanje, gozdarstvo, varstvo gozdov, napoved
Published in DiRROS: 11.11.2021; Views: 889; Downloads: 256
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108. Spremljanje smrekovih podlubnikov : pomen, metode in učinkovitostMaarten De Groot, Andreja Kavčič, Nikica Ogris, Marija Kolšek, 2021, other monographs and other completed works Keywords: smrekov podlubnik, režasta past, feromonska past, podlubniki, spremljanje, gozdarstvo, varstvo gozdov
Published in DiRROS: 11.11.2021; Views: 907; Downloads: 315
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109. Učinki usposabljanj za sistem za zgodnje obveščanje in hitro odzivanje (ZOHO) na tujerodne vrste v slovenskih gozdovihBoris Rantaša, Andreja Gregorič, Lidija Turk, Marija Kolšek, Maarten De Groot, Andrej Verlič, Simon Zidar, Andreja Kavčič, Nikica Ogris, Lado Kutnar, Aleksander Marinšek, Barbara Piškur, Dušan Jurc, Janez Kermavnar, Špela Jagodic, Jana Kus Veenvliet, Judita Malovrh, 2021, professional article Abstract: Prepoznavanje invazivnih tujerodnih vrst (ITV) na terenu in hiter odziv na nove najdbe ITV v gozdovih sta med ključnimi izzivi gozdarske stroke. Z namenom krepitve zmogljivosti za zgodnje zaznavanje tujerodnih vrst v gozdovih je bilo v okviru projekta Osveščanje, usposabljanje in ukrepanje za invazivne tujerodne vrste v gozdu (LIFE ARTEMIS), ki je potekal v letih 2016-2020, 33 izobraževanj po Sloveniji in eno v tujini. Skupno se je izobraževanj udeležilo 1.059 udeležencev. Izobraževanja so bila izvedena za izvajalce usposabljanj, strokovnjake, lastnike gozdov, prostovoljce in zaposlene v podjetjih, povezanih z gozdom. Izobraževalni cilji usposabljanj so bili doseženi. Analiza samoocenjevalnih vprašalnikov udeležencev izobraževanj je pokazala, da so bili pred usposabljanjem malo do srednje usposobljeni, po usposabljanju pa srednje do dobro. Pred usposabljanjem je manj kot polovica anketirancev vedela, kako se odzvati, ko opazijo ITV v gozdu. Po usposabljanju pa je to vedelo več kot 90 % anketiranih. Po usposabljanju za prenos sistema za zgodnje obveščanje in hitro odzivanje (ZOHO) v druge evropske države je več kot 80 % anketiranih odgovorilo, da so se naučili nekaj novega o ITV, 79 % anketiranih pa si želi tudi v prihodnje sodelovati v sistemu ZOHO. Udeleženci si v prihodnje želijo predvsem dodatnih znanj na področju prepoznavanja ITV ter več terenskih izobraževanj. V prispevku predstavljamo rezultate spremljanja uspešnosti usposabljanj in razpravo o morebitni potrebi po dodatnih usposabljanjih na področju obveščanja in hitrega odzivanja za tujerodne vrste v gozdnem prostoru.
Keywords: izobraževanje, invazivke, invazivne tujerodne vrste, sistem za zgodnje obveščanje in hitro odzivanje, anketiranje ciljnih skupin, gozdovi, Slovenija
Published in DiRROS: 26.10.2021; Views: 1216; Downloads: 353
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110. Immunotherapy for metastatic non-small cell lung cancer : real-world data from an academic Central and Eastern European centerMarija Ivanović, Lea Knez, Ana Herzog, Mile Kovačević, Tanja Čufer, 2021, original scientific article Abstract: Background. Immunotherapy with immune checkpoint inhibitors (ICIs) recently became the standard treatment for patients with advanced non-small cell lung cancer (NSCLC). Here, we present the first results of a real-world observational study on the effectiveness of ICI monotherapy in patients with advanced NSCLC treated at a single academic center in a Central and Eastern European (CEE) country. Materials and methods. Overall, 66 consecutive patients with advanced NSCLC treated with ICIs in everyday clinical practice, either with first-line pembrolizumab (26 patients) or second-line atezolizumab, nivolumab, or pembrolizumab (40 patients), from August 2015 to November 2018, were included. All data were retrieved from a hospital lung cancer registry, in which the data is collected prospectively. Results. Included patients had a median age of 64 years, most were male (55%), 6% were in performance status >/=2, and 18% had controlled central nervous system metastases at baseline. In first-line, the median progression-free survival (mPFS) was 9.3 months, while the median overall survival (mOS) was not reached. The 1-year overall survival (OS) was 62%. In second-line, the mPFS and mOS were 3.5 months and 9.9 months, respectively, with a 1-year OS of 35%. In the overall population, adverse events of any grade were recorded in 79% of patients and of severe grade (3-4) in 12% of patients. Conclusion. The first real-world outcomes of NSCLC immunotherapy from a CEE country suggest comparable effectiveness to those observed in clinical trials and other real-world series, mainly coming from North America and Western European countries. Further data to inform on the real-world effectiveness of immunotherapy worldwide are needed.
Keywords: non-small cell lung carcinoma, immunotherapy, advanced non-small cell lung cancer, real-world data, Central Europe, Europe, Eastern Europe
Published in DiRROS: 12.10.2021; Views: 943; Downloads: 287
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