31. Priporočila za obravnavo bolnikov s pljučnim rakomMartina Vrankar, Nina Boc, Izidor Kern, Aleš Rozman, Karmen Stanič, Tomaž Štupnik, Mojca Unk, Maja Ebert Moltara, Vesna Zadnik, Katja Adamič, Jernej Benedik, Marko Bitenc, Jasna But-Hadžić, Anton Crnjac, Marina Čakš, Dominik Časar, Eva Ćirić, Tanja Čufer, Ana Demšar, Rok Devjak, Goran Gačevski, Marta Globočnik Kukovica, Kristina Gornik-Kramberger, Maja Ivanetič Pantar, Marija Ivanović, Urška Janžič, Staša Jelerčič, Veronika Kloboves-Prevodnik, Mile Kovačević, Luka Ležaič, Mateja Marc-Malovrh, Katja Mohorčič, Loredana Mrak, Igor Požek, Nina Turnšek, Bogdan Vidmar, Dušanka Vidovič, Gregor Vlačić, Ana Lina Vodušek, Rok Zbačnik, Ivana Žagar, 2023, professional article Abstract: Leta 2019 so bila objavljena Priporočila za obravnavo bolnikov s pljučnim rakom, ki so v slovenski prostor vnesla prepotrebno poenotenje diagnostike in zdravljenja z namenom izboljšanja preživetja bolnikov s pljučnim rakom. Posodobitev Priporočil tri leta po izidu izvirnika prinaša največ novosti v poglavju o sistemskem zdravljenju bolnikov s pljučnim rakom. To kaže na izjemen napredek na področju razumevanja onkogeneze in biologije pljučnega raka ter s tem razvoja novih zdravil. Breme pljučnega raka ostaja veliko, saj je pljučni rak pri nas in v svetu še vedno najpogostejši vzrok smrti zaradi raka. Za vsako peto smrt zaradi raka je odgovoren pljučni rak. Skoraj tretjina bolnikov s pljučnim rakom ne prejme specifičnega onkološkega zdravljenja, bodisi zaradi slabega stanja zmogljivosti, spremljajočih bolezni ali obsega bolezni. Polovica bolnikov ima ob diagnozi razsejano bolezen, zaradi česar izboljšanje preživetja z malimi koraki sledi napredku v zdravljenju bolnikov s pljučnim rakom. Ti podatki nas opominjajo, da se bomo morali za velike premike v obravnavi bolnikov s pljučnim rakom lotiti drugačnih pristopov. Kot najbolj obetavno se ponuja zgodnje odkrivanje bolezni, ko so možnosti ozdravitve pljučnega raka najboljše. Zapisana Priporočila so usmeritev za obravnavo bolnikov s pljučnim rakom. Le s sodobnim multidisciplinarnim pristopom obravnave lahko bolniku ponudimo zdravljenje, ki mu omogoča najboljši izhod prognostično neugodne bolezni.
Keywords: pljučni rak, priporočila
Published in DiRROS: 27.07.2023; Views: 422; Downloads: 148
 Full text (708,18 KB)
This document has many files! More... |
32. Analiza izbranih drevesnih modelov razvoja gozdov, primernih za modeliranje na velikoprostorski ravni, in možnosti njihove uporabe v SlovenijiJernej Jevšenak, Boštjan Mali, Mitja Skudnik, 2023, original scientific article Abstract: Prispevek obravnava drevesne modele razvoja gozdov, ki so pomembno orodje pri odločanju, upravljanju in strateških odločitvah na področju gospodarjenja z gozdovi. V Sloveniji smo šele v zadnjih letih pričeli s sistematičnim razvojem področja modeliranja gozdov, ki vključuje razvoj matričnega populacijskega modela, testiranje izbranih modelov iz tujine ter razvoj posameznih komponent modelov. Namen prispevka je predstaviti področje empiričnih drevesnih modelov za modeliranje razvoja gozdov na velikoprostorski ravni. Podrobneje predstavljamo uveljavljene metode za modeliranje posameznih komponent drevesnih modelov, kot so debelinska in višinska rast, razvoj krošnje, mortaliteta ter vrast in pomlajevanje. Opravili smo presojo primernosti izbranih drevesnih modelov z vidika možnost njihove uporabe v Sloveniji. Ugotavljamo, da imajo modeli SILVA, WEHAM, MASSIMO in CALDIS največje možnosti za uporabo v Sloveniji, saj so vsi primerni za različne gozdne tipe in mešane gozdove z raznomerno zgradbo, ki prevladujejo v Sloveniji. Poleg testiranja obstoječih modelov predlagamo razvoj novih modelov, prilagojenih raznomernim in mešanim sestojem v Sloveniji. Predlagamo tudi razširitev nabora kazalnikov pri gozdnih inventurah ter dodatne meritve značilnosti dreves, npr. lastnosti krošenj, ki bi razširile možnosti modeliranja razvoja gozdov v Sloveniji. V zaključkih razpravljamo tudi o možnosti uporabe strojnega učenja na področju modeliranja razvoja gozdov, saj bi tovrstni modeli lahko predstavljali naslednjo generacijo modelov.
Keywords: modeliranje, razvoj gozda, velikoprostorska gozdna inventura, stalne vzorčne ploskve, simulator razvoja gozdov, napovedovanje, gozdarska politika
Published in DiRROS: 27.06.2023; Views: 1236; Downloads: 589
Full text (1,20 MB)
This document has many files! More... |
33. Causes and consequences of large-scale windthrow on the development of fir-beech forests in the Dinaric mountainsMatjaž Čater, Ajša Alagić, Mitja Ferlan, Jernej Jevšenak, Aleksander Marinšek, 2023, original scientific article Abstract: We investigated several aspects of windthrow that are relevant to our understanding and management of forest ecosystems. As an example, we used an extreme event in December 2017, when the strongest storm in recent history occurred in the Slovenian Dinaric High Karst. We examined influential factors such as soil properties, wind speed, precipitation and ecological consequences for the affected forests. Soil properties were measured around standing and fallen silver fir trees at all three research sites. Tree species composition in the regeneration was observed on plots with chemical and acoustic ungulate deterrents and on control plots without deterrents. Economic estimates of yield loss due to damage were calculated at the national level. A model of the potential threat from windthrow was also developed based on data collected from windthrow events and meteorological data over the past 20 years. Our results indicate that soil depth and mineral fraction depth were similar at sites with and without damaged trees and were not the determining factors for tree toppling. Plots with acoustic deterrents showed the most effective regeneration development, the least decline in silver fir and the greatest increase in noble hardwood seedlings, while plots with chemical deterrents showed the least browsing damage. The estimated economic loss of €16.1 million is 6.6% less than the harvest under normal conditions. The economic loss was relatively low due to the nature of the storm, with the predominant type of damage being uprooted trees with no damaged trunks. The windthrow hazard model revealed that a large number of consecutive events with strong winds in each section weakened the stand, which was subsequently knocked down during the next extreme wind and rainfall event.
Keywords: natural forest regeneration, windthrow, economic loss, browsing, ungulate deterrents, forest soil properties, potential threat model
Published in DiRROS: 27.06.2023; Views: 1176; Downloads: 546
Full text (2,26 MB)
This document has many files! More... |
34. Organoidi glioblastoma razkrivajo odpornost na standardno terapijoBernarda Majc, Anamarija Habič, Marta Malavolta, Aleksander Sadikov, Andrej Porčnik, Jernej Mlakar, Tamara Lah Turnšek, Barbara Breznik, Metka Novak, 2023, published scientific conference contribution abstract Keywords: glioblastom, organoidi, standardna terapija, model ex vivo, biologija raka
Published in DiRROS: 16.06.2023; Views: 371; Downloads: 134
Full text (345,36 KB)
This document has many files! More... |
35. Evaluation of sediments from the river Drava and their potential for further use in the building sectorVilma Ducman, Karmen Fifer Bizjak, Barbara Likar, Mitja Kolar, Ana Robba, Jernej Imperl, Mojca Božič, Boštjan Gregorc, 2022, original scientific article Abstract: Sedimentation is a naturally occurring process of allowing particles in water bodies to settle out of the suspension under a gravity effect. In this study, the sediments of the Drava River were fully investigated to determine the heavy metal concentrations along the river and their potential reuse in the construction sector. Naturally dehydrated sediments from the Drava River were tested as an additive for the production of fired bricks. The dredged sediments were used as a substitute for natural brick clay in amounts up to 50% by weight, and it was confirmed that up to 20% by weight of the added sediment could be used directly in the process without critically affecting performance. Finally, the naturally dehydrated sediments were also evaluated for their use as a filling material in the construction of levees. The natural moisture content of the dehydrated sediment was too high for it to be used without additives, so quicklime was added as an inorganic binder. The test results showed an improvement in the geotechnical properties of the material to such an extent that it is suitable as a filling material for levees.
Keywords: sediment, pollution, clay industry, soil stabilization, open access
Published in DiRROS: 31.05.2023; Views: 339; Downloads: 173
Full text (3,20 MB)
This document has many files! More... |
36. |
37. |
38. |
39. |
40. |
