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Query: "author" (Irena Hočevar-Boltežar) .

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1.
Communication after laryngectomy
Irena Hočevar-Boltežar, Miha Žargi, 2001, review article

Abstract: Izhodišča. Pri bolnikih z napredovalim rakom grla in spodnjega žrela je kirurška odstranitev grla najbolj primeren način zdravljenja. To zdravljenje pa negativno vpliva na številne pomembne bolnikove funkcije in tudi na govor. Bolniki in metode dela. Po odstranitvi grla je možnih več različnih načinov tvorbe glasu, tako da se vsak laringektomirani bolnik lahko nauči katerega od teh načinov govornega sporazumevanja. Rezultati. Znanih je več različnih, tudielektronskih naprav, ki s pomočjo lastnih baterij proizvajajo zvok. Drugo možnost predstavlja ezofagalni govor, pri katerem se bolnik nauči uporabljati mišični segment na prehodu v zgornji požiralnik kot generator glasu. Kirurško možnost govorne rehabilitacije po laringektomiji pa predstavlja vstavitev proteze v kirurško narejeno fistulo med zgornjim požiralnikom in sapnikom. Proteza usmeri zrak iz pljuč v zgornji požiralnik, glas pa nastane pri prehoduzraka skozi že omenjeni mišični segment. Zaključki. Številni dejavniki vplivajo na izbiro najprimernejšega načina nadomestnega govora pri posameznem bolniku. V Sloveniji največ laringektomiranih bolnikov uporablja ezofagalni govor.
Published in DiRROS: 25.01.2024; Views: 141; Downloads: 34
.pdf Full text (82,96 KB)

2.
Factors influencing rehabilitation in patients with head and neck cancer
Irena Hočevar-Boltežar, Alojz Šmid, Miha Žargi, Avgust Župevc, Igor Fajdiga, Janez Fischinger, Ana Jarc, 2000, original scientific article

Abstract: Purpose. The purpose of the prospective study was to identify the factors adversely influencing the post-treatment rehabilitation in patients with head and neck cancer. Patients and methods. One hundred and ten patients with oral cavity, pharyngeal and laryngeal cancer were examined before surgical treatment in order to find unfavorable factors: hearing loss, defective teeth,impaired pulmonary function, and speech disorders. The patients evaluated the success of their rehabilitation 12 months after the treatment. The influence of possible unfavorable factors, tumor site, and type of surgeryon speech, swallowing and reintegration competence was determinated. Results. The site of the tumor and the type of surgery did not influence the quality of rehabilitation in general. Defective teeth influenced the ability of swallowing but not the speech. Hearing loss impaired the patient's reintegration in their home environment. Impaired pulmonary function did not affect patient's speech. Speech was the poorest in laryngectomized patients. However, about two thirds of the patients were satisfied with their capabilityof speech, swallowing and their rehabilitation in general. Conclusions. Early identification of unfavorable factors, and individually planned rehabilitation can ensure a suitable quality of life for patients thathave undergone surgery for head and neck cancer.
Published in DiRROS: 25.01.2024; Views: 119; Downloads: 36
.pdf Full text (322,91 KB)

3.
Voice quality after radiation therapy of early glottic cancer
Irena Hočevar-Boltežar, Miha Žargi, 1997, original scientific article

Abstract: Radiation therapy is generally accepted as a successful treatment modality forearly glottic cancer offering an acceptable voice quality after the treatment. In order to evaluate objectively the voice quality in irradiated patients and to eliminate the influence of decreasing voice quality as a result of normal aging, the results of the acoustic analysis of voice in 20 patients with early glottic cancer treated with radiation therapy were compared to the results of 20 age-matched volunteers. The results established worse voice quality in the irradiated group but the difference was not significant except in amplitude perturbation quotient which expresses the instability of loudness. In order to identity the factors which could influence the quality of voice after irradiation of the laryngeal carcinoma, the results of laryngoscopy and the biopsy extension, were correlated with theresults of the perceptive voice evaluation and the results of acoustic voice analysis. No significant influence of the stated factors on the voice quality of the patients was established. Only the irregular glottic gap duringphonation indicated to be connected with very hoarse voice. In conclusion, radiation therapy of early glottic cancer results in an abnormal, but still satisfactory voice quality when compared to the voice quality of normal age-matched speakers. The hoarseness is the results of instability of pitch and specifically the instability of amplitude (loudness). The voice quality after the treatment can be influenced by the tumor extension and localization, the sequels of excisional biopsy, and the radiation therapy or functional disorder. All the stated factors are very intermingled and are probably acting together.
Published in DiRROS: 16.01.2024; Views: 179; Downloads: 43
.pdf Full text (285,65 KB)

4.
Možnosti rehabilitacije pri bolnikih z rakom glave in vratu
Irena Hočevar-Boltežar, 2022, published professional conference contribution

Abstract: Rak glave in vratu je osmi najpogostejši rak v Sloveniji. Zdravimo ga kirurško, z radioterapijo in kemoterapijo, pogosto s kombinacijo teh načinov zdravljenja. Ker pa rak glave in vratu prizadene nos, ustno votlino, žrelo in grlo, so kot posledica bolezni same in nato zdravljenja okvarjene številne pomembne funkcije, ki vključujejo: dihanje, požiranje, govor, kašelj in vohanje. Za čim boljšo rehabilitacijo prizadetih funkcij je treba najprej natančno ugotoviti, kateri organi so prizadeti in kako okvarjeni so ter kakšne so preostale zmožnosti za izvedbo opisanih funkcij. Na podlagi ustreznih preiskav izberemo način rehabilitacije za vsakega bolnika posebej. V diagnostiko okvarjenih funkcij in rehabilitacijo je vključena vrsta različnih strokovnjakov, v rehabilitaciji pa je vodilni ustrezno usposobljen specialist klinične logopedije. Dobra rehabilitacija okvarjenih funkcij omogoča bolniku večjo kakovost življenja.
Keywords: rak glave in vratu, požiranje, govor, voh, rehabilitacija
Published in DiRROS: 06.01.2023; Views: 397; Downloads: 92
.pdf Full text (108,21 KB)

5.
CD3+CD4-CD8- mucosal T cells are associated with uncontrolled chronic rhinosinusitis with nasal polyps
Tanja Soklič, Mira Šilar, Matija Rijavec, Ana Koren, Izidor Kern, Irena Hočevar-Boltežar, Peter Korošec, 2019, short scientific article

Abstract: Increased mucosal double-negative (DN) CD3+CD4-CD8- T cells were found for the first time in CRS and were much more abundant in uncontrolled CRSwNP than in well-controlled CRSwNP.
Keywords: chronic rhinosinusitis, CD3+ T-cells, CD4- T-cells, CD8- T-cells
Published in DiRROS: 22.10.2020; Views: 1516; Downloads: 497
URL Link to file

6.
Transcription factors gene expression in chronic rhinosinusitis with and without nasal polyps
Tanja Soklič, Matija Rijavec, Mira Šilar, Ana Koren, Izidor Kern, Irena Hočevar-Boltežar, Peter Korošec, 2019, original scientific article

Abstract: Background. Chronic rhinosinusitis (CRS) current therapeutic approaches still fail in some patients with severe persistent symptoms and recurrences after surgery. We aimed to evaluate the master transcription factors gene expression levels of T cell subtypes in chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP) that could represent new, up-stream targets for topical DNAzyme treatment. Patients and methods. Twenty-two newly diagnosed CRS patients (14 CRSwNP and 8 CRSsNP) were prospectively biopsied and examined histopathologically. Gene expression levels of T-box transcription factor (T-bet, TBX21), GATA binding protein 3 (GATA3), Retinoic acid-related orphan receptor C (RORC) and Forkhead box P3 (FOXP3) were analyzed by real-time quantitative polymerase chain reaction (RT-qPCR). Results. Eosinophilic CRSwNP was characterized by higher level of GATA3 gene expression compared to noneosinophilic CRSwNP, whereas there was no difference in T-bet, RORC and FOXP3 between eosinophilic and noneosinophilic CRSwNP. In CRSsNP, we found simultaneous upregulation of T-bet, GATA3 and RORC gene expression levels in comparison to CRSwNP; meanwhile, there was no difference in FOXP3 gene expression between CRSwNP and CRSsNP. Conclusions. In eosinophilic CRSwNP, we confirmed the type 2 inflammation by elevated GATA3 gene expression level. In CRSsNP, we unexpectedly found simultaneous upregulation of T-bet and GATA3 that is currently unexplained; however, it might originate from activated CD8+ cells, abundant in nasal mucosa of CRSsNP patients. The elevated RORC in CRSsNP could be part of homeostatic nasal immune response that might be better preserved in CRSsNP patients compared to CRSwNP patients. Further data on transcription factors expression rates in CRS phenotypes are needed.
Keywords: sinusitis, nasal polyps, Th1 cells, Th2 cells, Th17 cells, transcription factors, chronic rhinosinusitis
Published in DiRROS: 09.10.2020; Views: 1436; Downloads: 798
.pdf Full text (698,54 KB)
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7.
Rehabilitacija bolnikov po operaciji raka v ORL področju
Irena Hočevar-Boltežar, Zora Radšel, 1995, published professional conference contribution

Keywords: onkologija, rak (medicina), zdravljenje, otorinolaringologija, kirurgija, rehabilitacija
Published in DiRROS: 20.05.2020; Views: 1314; Downloads: 360
.pdf Full text (359,90 KB)

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