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Keywords: low density steels, heat treatment, tensile test
Published in DiRROS: 02.02.2024; Views: 136; Downloads: 72
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Abstract: V prispevku je predstavljen sestojni simulator MORSE (MOdel Razvoja SEstojev), ki omogoča simuliranje razvoja enomernih mešanih sestojev na ravni posameznih sestojev in večji prostorski ravni. Zgrajen je iz treh modulov, ki obravnavajo rast, mortaliteto in ukrepanje (redčenje in obnova). Regresijski model razvoja dominantnega premera sestojev je temeljni algoritem, izdelan na podlagi empiričnih podatkov. Za zagon simulatorja so potrebni vhodni podatki o sestojnih in rastiščnih znakih, ki so preprosto določljivi. MORSE simulira razvoj sestojev za obdobje dvesto let glede na upravljavske odločitve o redčenju (jakost, pogostnost, zvrst, pospeševanje drevesnih vrst) in obnovi (ciljne velikosti, pomladitvena doba, čas in jakost pomladitvenih sečenj, pomladitveni cilj). Mogoča sta dva načina določanja režima redčenj: i) eksplicitna določitev terminov in jakosti redčenj in ii) posredna glede na primerjavo dejanske in optimalne temeljnice sestoja. Razvoj sestojnih znakov za opredeljeno obdobje je prikazan grafično in v preglednicah. Za isto obdobje so navedeni parametri poseka in mortalitete drevja. MORSE je sedaj v fazi preverjanja na sestojni ravni, potem sledi razvoj simulatorja na večji prostorski ravni. V prispevku so prikazane variante razvoja testnega sestoja glede na različno ukrepanje.
Keywords: modeliranje, rast, mortaliteta, redčenje, obnova, dominantni premer, gozdnogospodarsko načrtovanje
Published in DiRROS: 22.12.2022; Views: 556; Downloads: 165
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Abstract: Hereditary angioedema with C1 Inhibitor deficiency (C1-INH-HAE) is caused by a constellation of variants of the SERPING1 gene (n = 809; 1,494 pedigrees), accounting for 86.8% of HAE families, showing a pronounced mutagenic liability of SERPING1 and pertaining to 5.6% de novo variants. C1-INH is the major control serpin of the kallikrein–kinin system (KKS). In addition, C1-INH controls complement C1 and plasminogen activation, both systems contributing to inflammation. Recognizing the failed control of C1s protease or KKS provides the diagnosis of C1-INH-HAE. SERPING1 variants usually behave in an autosomal-dominant character with an incomplete penetrance and a low prevalence. A great majority of variants (809/893; 90.5%) that were introduced into online database have been considered as pathogenic/likely pathogenic. Haploinsufficiency is a common feature in C1-INH-HAE where a dominant-negative variant product impacts the wild-type allele and renders it inactive. Small (36.2%) and large (8.3%) deletions/duplications are common, with exon 4 as the most affected one. Point substitutions with missense variants (32.2%) are of interest for the serpin structure–function relationship. Canonical splice sites can be affected by variants within introns and exons also (14.3%). For noncanonical sequences, exon skipping has been confirmed by splicing analyses of patients' blood-derived RNAs (n = 25). Exonic variants (n = 6) can affect exon splicing. Rare deep-intron variants (n = 6), putatively acting as pseudo-exon activating mutations, have been characterized as pathogenic. Some variants have been characterized as benign/likely benign/of uncertain significance (n = 74). This category includes some homozygous (n = 10) or compound heterozygous variants (n = 11). They are presenting with minor allele frequency (MAF) below 0.00002 (i.e., lower than C1-INH-HAE frequency), and may be quantitatively unable to cause haploinsufficiency. Rare benign variants could contribute as disease modifiers. Gonadal mosaicism in C1-INH-HAE is rare and must be distinguished from a de novo variant. Situations with paternal or maternal disomy have been recorded (n = 3). Genotypes must be interpreted with biological investigation fitting with C1-INH expression and typing. Any SERPING1 variant reminiscent of the dysfunctional phenotype of serpin with multimerization or latency should be identified as serpinopathy.
Keywords: Hereditary angioedemas -- genetics -- diagnosis, genetic variation, serpins, SERPING1 gene, C1-INH, C1-INH-HAE, C1 inhibitor, serpinopathy
Published in DiRROS: 06.04.2022; Views: 863; Downloads: 523
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Abstract: Analizirali smo rast duglazije (Pseudotsuga menziesii (Mirb.) Franco) in smreke (Picea abies (L.) Karst.) na produktivnem rastišču na Pečovniku pri Celju. Analizirane duglazije so bile nekoliko mlajše od smrek (67 proti 71 let) in so nekoliko bolje priraščale (4,57 mm proti 3,26 mm na leto). Podnebni odziv duglazije na produktivnem rastišču je bil zelo izrazit. Na debelinski prirastek so statistično značilno vplivale nadpovprečne temperature v februarju in marcu, ter nadpovprečne padavine v juliju. V primerjavi s smreko je podnebni odziv duglazije časovno stabilen in bistveno izrazitejši. Analiza značilnih let je pokazala, da so negativna značilna leta pri duglaziji vedno povezana z zelo hladnim vremenom v februarju in marcu, pozitivna pa z nadpovprečnimi temperaturami v istih dveh mesecih. Poletne padavine imajo pomembnejšo vlogo pri duglaziji le v zadnjih treh desetletjih, pred tem pa ne. To nakazuje, da na sicer zelo produktivnem rastišču nastaja potencialno pomanjkanje vode, kar lahko na dolgi rok, ob trendih podnebnih sprememb, vodi v sušni stres in slabšo rast duglazije.
Keywords: podnebne spremembe, odziv na klimo, suša, debelinski prirastek, dendrokronologija
Published in DiRROS: 29.10.2021; Views: 1091; Downloads: 347
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Abstract: Purpose. Writing an Advance Directive (AD) is often seen as a part of Advance Care Planning (ACP). ADs may include specific preferences regarding future care and treatment and information that provides a context for healthcare professionals and relatives in case they have to make decisions for the patient. The aim of this study was to get insight into the content of ADs as completed by patients with advanced cancer who participated in ACP conversations. Methods. A mixed methods study involving content analysis and descriptive statistics was used to describe the content of completed My Preferences forms, an AD used in the intervention arm of the ACTION trial, testing the effectiveness of the ACTION Respecting Choices ACP intervention. Results. In total, 33% of 442 patients who received the ACTION RC ACP intervention completed a My Preferences form. Document completion varied per country: 10.4% (United Kingdom), 20.6% (Denmark), 29.2% (Belgium), 41.7% (the Netherlands), 61.3% (Italy) and 63.9% (Slovenia). Content analysis showed that 'maintaining normal life' and 'experiencing meaningful relationships' were important for patients to live well. Fears and worries mainly concerned disease progression, pain or becoming dependent. Patients hoped for prolongation of life and to be looked after by healthcare professionals. Most patients preferred to be resuscitated and 44% of the patients expressed maximizing comfort as their goal of future care. Most patients preferred 'home' as final place of care. Conclusions. My Preferences forms provide some insights into patients' perspectives and preferences. However, understanding the reasoning behind preferences requires conversations with patients.
Keywords: advance care planning, psycho-oncology, medical oncology, ACTION study, cancer, end of life, dying persons
Published in DiRROS: 15.02.2021; Views: 1308; Downloads: 900
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