931. Povzetek smernic diagnostike in zdravljenja diferenciranega raka ščitniceNikola Bešić, Marko Hočevar, Damijan Bergant, Barbara Vidergar-Kralj, Olga Blatnik, Veronika Kloboves-Prevodnik, Marta Dremelj, 2017, professional article Abstract: Med vsemi bolniki z raki, ki jih zdravimo, ima raka ščitnice le 1 %. Leta 2013 je bilo po podatkih Registra raka v Sloveniji zdravljenih 160 bolnikov z rakom ščitnice. Porast števila bolnikov z rakom ščitnice v zadnjem desetletju je skoraj v celoti zaradi papilarnega raka ščitnice, še posebno papilarnega mikrokarcinoma, ki ima odlično prognozo. Velika večina bolnikov z rakom ščitnice je povsem ozdravljena. Zaradi dobre prognoze bolnikov z rakom ščitnice je v zadnjem desetletju prišlo do bistvenih sprememb v obravnavi bolnikov z rakom ščitnice. Strokovnjaki z Onkološkega inštituta, Klinike za nuklearno medicino UKC Ljubljana in Inštituta za patologijo Medicinske fakultete v Ljubljani smo pripravili Smernice diagnostike in zdravljenja raka ščitnice, v katerih so opisani sodobni postopki diagnosticiranja in zdravljenja raka ščitnice.
Keywords: rak ščitnice, zdravljenje, diagnostika, diferencirani rak ščitnice, smernice
Published in DiRROS: 13.12.2017; Views: 3968; Downloads: 957
 Full text (278,17 KB) |
932. Proteases and cytokines as mediators of interactions between cancer and stromal cells in tumoursBarbara Breznik, Helena Motaln, Tamara Lah Turnšek, review article Abstract: Proteolytic enzymes are highly relevant in different processes of cancer progression. Their interplay with other signalling molecules such as cytokines represents important regulation of multicellular cross-talk. In this review, we discuss protease regulation mechanisms of cytokine signalling in various types of cancer. Additionally, we highlight the reverse whereby cytokines have an impact on protease expression in an autocrine and paracrine manner, representing complex feedback mechanisms among multiple members of these two protein families. The relevance of the protease-cytokine axis is illustrated in glioblastoma, where interactions between normal mesenchymal stem cells and cancer cells play an important role in this very malignant form of brain cancer.
Keywords: cellular cross-talk, glioblastoma, invasion, mesenchymal stem cells, protease-cytokine signalling
Published in DiRROS: 08.09.2017; Views: 3993; Downloads: 1383
Full text (951,87 KB) |
933. |
934. |
935. On the use of R programming language in the analyses of spatial dataMilan Kobal, Andrej Ceglar, Klemen Eler, Barbara Medved Cvikl, Luka Honzak, Primož Simončič, David Hladnik, 2013, original scientific article Abstract: R is a powerful and increasingly popular programming language with strong graphical and presentation features and large expanŽdability. Although primarily intended for statistical computing, R has paved its way to the field of GIS through the development of specialized extension packages. It offers a wide range of functions at all GIS levels: data acquisition, data manipulation, graphical reŽpresentation and quantitative analysis. The paper presents R as an open source alternative to the existing commercial GIS software. It proves especially well when advanced quantitative methods on spatial data are needed (e.g. spatial modelling). We demonstrate R capabilities through spatial analysis of forest area in Snežnik (South Slovenia), where the possibilities of data import, conversion and export into various GIS formats and possibilities of geostatistics, spatial modelling and spatial visualization are demonstrated.
Published in DiRROS: 12.07.2017; Views: 5171; Downloads: 2707
Full text (2,43 MB) |
936. Vpliv nekaterih ekoloških dejavnikov na pojavljanje gozdnega jereba Bonasa bonasia v BohinjuBarbara Mihelič, Tomaž Mihelič, 2004, original scientific article Abstract: Avtorja članka sta raziskovala vpliv nekaterih ekoloških dejavnikov na pojavljanje gozdnega jereba na osmih lokacijah v Bohinju.Na 143 popisnih točkah sta ugotovila 25 teritorialnih samcev. Poleg tega sta na podlagi naključnih opazovanj zbrala tudi 79 različnih lokacij pojavljanja vrste v Bohinju. Gozdni jerebi so naseljevali višje nadmorske višine. Osrednji del populacije je bil ugotovljen med 1280 in 1490 m n.m. Primerjava naključno in sistematično zbranih podatkov ni pokazala razlik. Delež listavcev v gozdu na pojavljanje gozdnega jereba ni imel vpliva. Večina gozdnih jerebov je bila zabeležena na ploskvah z večjim deležem iglavcev, vendar se te ploskve niso razlikovale od drugih popisnih ploskev. Delež grmovne in zeliščne plasti ter delež negozdnih površin in jas so imeli pomemben vpliv na pojavljanje gozdnegajereba. Gozdni jerebi so bili prisotni na ploskvah z večjo pokrovnostjo tako grmovne kot zeliščne plasti, kakor tudi na ploskvah z večjimdeležem negozdnih površin. Glavni razlog za pojavljanje negozdnih površin v habitatu gozdnega jereba je pašništvo. Pašništvo v obliki planin ugodno vpliva na številčnost gozdnega jereba, saj spodbuja tri pomembne komponente njegovega habitata (zvečevanje deleža jas ter deleža pokrovnosti v grmovni in zeliščni plasti).
Keywords: gozdni jereb, ekološki dejavniki, paša
Published in DiRROS: 12.07.2017; Views: 4198; Downloads: 1825
Full text (725,10 KB) |
937. |
938. |
939. Bioindikation in belasteten und unbelasteten GebietenFranc Batič, Cvetka Ribarič-Lasnik, Barbara Kruhar-Lorger, Dieter Grill, Edith Stabentheiner, Helmut Mayrhofer, Marietta Koch, Martin Grube, 1993, treatise, preliminary study, study Published in DiRROS: 12.07.2017; Views: 2619; Downloads: 654
Full text (8,49 MB) |
940. Improvement of truffle cultivation via novel quality control, soil analysis and inoculation methods : advanced inoculation methods, novel site selection tools and the establishmentof mycelial gene banks for economically important truffle specieswill improve truffle cultivation : Eureka: E! 3835-cultuber : final reportTine Grebenc, Marko Bajc, Melita Hrenko, Barbara Štupar, Igor Dakskobler, Gregor Božič, Nataša Milenković, Hojka Kraigher, Žaklina Marjanović, 2010, final research report Published in DiRROS: 12.07.2017; Views: 2957; Downloads: 768
Full text (915,02 KB) |
