21. Vinblastine increases antitumor effectiveness of bleomycinMaja Čemažar, Marija Auersperg, Gregor Serša, 1997, izvirni znanstveni članek Povzetek: In our previous vinblastine (VELBE) was shown to increase the plasma membrane fluidity. This effect of VELBE might be expolited for better transport of drugs through the plasma membrane. Bleomycin (BLM) is a highly cytotoxic drug when present inside the cells but has a hampered transport through the plasma membrane. The aim of the present study was to determine whether pretreatment with VELBE can increase the effect of BLM on intraperitoneal SA-1 tumors in mice. BLM and VELBE were used as single agents or in various combinations, i.e. VELBE and BLM injected simultanously, BLM injected 24 h before VELBE or VELBE injected 24 h before BLM. Mice survival was the end-point used for determining the effect of this combined treatments. VELBE and BLM as a single treatment significantly prolonged median survival time of study animals compared to controls. Furthermore, when VELBE and BLM were combined, all threetested combinations were more effective than VELBE or BLM as single treatments. The effect on animal survival was equal when VELBE was given 24 h after or simultanously with BLM. The longest survival, however was obtained when VELBE was injected 24 h before BLM. From these results we can conclude that the underlying mechanisms for more than additive effect of VELBE and BLM when VELBE was given 24 h before BLM could be attributed to an increased membrane fluidity, possibly in combination with a cell kinetic effect.
Objavljeno v DiRROS: 18.01.2024; Ogledov: 198; Prenosov: 50
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24. Prognostic value of staging laparotomy in supradiaphragmatic clinical stage I and II Hodgkin's diseaseMarjeta Vovk, Tatjana Šumi-Križnik, Marija Jenko-Fidler, Gabrijela Petrič-Grabnar, Marinka Kremžar, Janez Novak, Mojca Senčar, Branko Zakotnik, Alenka Vodnik-Cerar, Branimir Jakšić, 1996, izvirni znanstveni članek Povzetek: In the period 1974-1989, 219 patients with supradiaphragmatic clinical stage I and II Hodgkin's disease were treated at the Institute of Oncology in Ljubljana; of these 95 (43%) patients underwent staging laparotomy. Of laparotomized patients, those with pathological stage III-IV, and of non-laparotomized, those with unfavorable prognostic factors (B-symptoms, bulky mediastinum) received chemotherapy: the remaining patients were treated by irradiation. No statistically significant difference in the survival and disease-free survival between laparotomized and nonlaparotomized patients could be found.
Objavljeno v DiRROS: 16.01.2024; Ogledov: 237; Prenosov: 58
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25. Biological behaviour of lung carcinoids : a retrospective analysis of 71 patientsIzidor Kern, Tomaž Rott, Marija Zupančič, Jurij Šorli, Urška Gantar-Rott, Janez Eržen, Janez Orel, Bogo Hrabar, 1994, strokovni članek Ključne besede: rak (medicina), pljuča, pljučni rak, novotvorbe
Objavljeno v DiRROS: 11.01.2024; Ogledov: 213; Prenosov: 66
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27. Razširjenost dvojnozobega smrekovega lubadarja (Ips duplicatus) v Sloveniji v letu 2023Maarten De Groot, Tine Hauptman, Marija Kolšek, 2023, drugi znanstveni članki Povzetek: Članek prikazuje rezultate raziskave razširjenosti vrste Ips duplicatus (Sahlberg, 1836) v Sloveniji v letu 2023. Uporabili smo 14 režastih pasti tipa Theysohn, ki so bile opremljene s feromonom Dupliwit. V raziskavo smo vključili tudi tri križne prestrezne pasti brez feromona, ki so bile postavljene v sklopu drugega projekta in smo v njih odkrili vrsto I. duplicatus. Prisotnost vrste smo potrdili na šestih lokacijah, skupno pa smo ujeli osem osebkov. Predstavljena je razprava o pomenu teh najdb v kontekstu razširjenosti, spremljanja in upravljanja dvojnozobega smrekovega lubadarja.
Ključne besede: gozdovi, varstvo gozdov, monitoring, navadna smreka, Picea abies, podlubniki, invazivna tujerodna vrsta
Objavljeno v DiRROS: 10.01.2024; Ogledov: 291; Prenosov: 124
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28. Natural IFN-[alpha] for non-small-cell lung cancer with pleural carcinosisBerta Jereb, Gabrijela Petrič-Grabnar, Marjeta Terčelj-Zorman, Marija Us-Krašovec, Renata Mažuran, Evgen Šooš, Janez Stare, 1993, izvirni znanstveni članek Ključne besede: rak (medicina), karcinom, pljuča, zdravljenje, interferoni
Objavljeno v DiRROS: 10.01.2024; Ogledov: 307; Prenosov: 64
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29. Changes in the quantity of cathepsin D in irradiated human cells following treatment with hyperthermia and interferon [alpha]Danilo Petrović, Ana Ferle-Vidović, Janez Škrk, Marija Kaštelan, Ivan Vrhovec, 1993, izvirni znanstveni članek Ključne besede: radiacija, biokemija, encimi, proteini, katepsin, celice
Objavljeno v DiRROS: 10.01.2024; Ogledov: 271; Prenosov: 64
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