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Povzetek: Background. The aim of the study was the evaluation of clinical utility and comparison of 111 In-DTPA- octreotide receptor scintigraphy (SRS) with conventional imaging modalities (CIM) in the detection of carcinoid tumor. Patients and methods. Fourteen patients with pathohistologically proven diagnosis of carcinoid tumor and one patient with clinical suspicion of carcinoid tumor were investigated by SRS. SRS was performed for localization of primary tumor, recurrence or estimation of spread of the disease after CIM had been completed. Whole body scans and single photon emission computed tomography (SPECT) were acquired 6 and 24 h after the application of radiopharmaceutical. The intensity of nonspecific radiopharmaceutical uptake in the bowel was assessed semiquantitatively by a score using whole body scans. Results. The evaluation was done for patients and for tumor sites. The sensitivity, specificity, and positive and negative predictive values for patient evaluation were 89 %,100 %,100 % and 80 %, respectively for both CIM and SRS, whereas for tumor sites, these parameters were 69 % 100 %,100 % and 82 % for CIM, and 88%,100%,100% and 92 % for SRS. Intensity score of nonspecific 111In-octreotide bowel accumulation was 0.92 and 2.01 for 6 and 24h scans respectively (p < 0.01). Conclusion. 111In-octreotide scintigraphy should be included in the diagnostic algorithm for the patients with clinical suspicion of carcinoid and for the assessment of patients with proven carcinoid tumor.
Objavljeno v DiRROS: 22.01.2024; Ogledov: 235; Prenosov: 47
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Povzetek: Background. The aim of this study was to determine the interaction between electrochemotherapy as a means of facilitated cisplatin delivery into the cells and irradiation of adenocarcinoma skin metastases. Case report. A patient with progressive disease presenting skin metastases of tubal dedifferentiated pappilary adenocarcinoma was enrolled in the study. Skin metastases were treated by electrochemotherapy with intratumoral injection of cisplatin. Its antitumor effectiveness was compared to that of combined treatment of irradiation with electrochemotherapy. After a two week observation time, the response to treatment was comparable between the electrochemotherapy and electrochemotherapy combined with irradiation. Both ofthese treatments were more effective than irradiation alone. Furthermore, antitumor effectiveness of the combined electrochemo- and radiotherapy was found to be quicker than that of electrochemotherapy alone. Comment. This study shows that electrochemotherapy with cisplatin is also effective in the treatment of adenocarcinoma skin metastases. Inspite of the short observation time, positive interaction between radiotherapy and electrochemotherapy with cisplatin was found.
Objavljeno v DiRROS: 22.01.2024; Ogledov: 266; Prenosov: 71
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Povzetek: Buckground. Endoanal ultrasound (EUS) is helpful in the diagnosis of anorectalfistulas and abscesses due to its high resolution image quality and anatomical orientation using a radial scanning echoprobe. This type of information is essential in monitoring the response to treatment. Initial EUS examination prior to treatment, is mandatory in order to compare the results before and after treatment. Intraoperative EUS may also be helpful if the lesion is deep beyond the pelvic floor muscle which may not be seen during surgery. Better results in EUS imaging of perianorectal fistulas can be obtained using hydrogen peroxide as a contrast medium. Concomitant advantage of hydrogen peroxide ultrasound was the detection of suspected or unsuspected sphincter defects. However, interobserver reliability has to be taken into account together with the learning curve of a particular observer. Conclusions. Endoanal US is a safe, economic, and reliable procedure for the assessment of fistula-in-ano, and is superior to physical examination.
Objavljeno v DiRROS: 22.01.2024; Ogledov: 235; Prenosov: 53
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Povzetek: Background. A computer system HIPSTRESS is described. The system can be used for the determination of the contact stress distribution in the hip joint for a known body weight and some characteristic pelvic and hip geometrical parameters which can be determined directly from the standard antero-posteriorradiograph. Conclusions. The system can be applied in clinicalpractice to predict an optimal stress distribution in different operative interventions in the hip.
Objavljeno v DiRROS: 22.01.2024; Ogledov: 237; Prenosov: 71
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Povzetek: Tlle aim of this study zuas to determine antitumor effectiveness of cryosurgery alone and in comhination with radiotherapy. Cryosurgery of subcutaneous fibrosarcoma SA-1 tumors in A/J mice was moderately effective trcatmcnt. Tumor growth delay was 10.3 * 3.8 days after 5 minute treatment with nitrogen filled cryo-prohe. Shorter treatment times induced less, but dose dependent antitumor effect. In combined treat- ment, tumors were either first treated by cryosurgery for 3 minutes and then locally irradiated with 10Gy for 5 minutes, or irradiated first and thereafter treated by cryosurgery.The antitumor effectiveness of com- bined treatrnent was sequence dependent; the irradiation of tumors before cryosurgery resulted in better antitumor effect than the irradiation after cryosurgery. These results indicate that radiosensitization may not be always expected, in spite of some reports demonstrating that cryosurgery may have radiosensitizing effect in vivo, and that some other mechanisms may be involved contributing to radiationdamage when cryosurgery follows irradiation.
Objavljeno v DiRROS: 22.01.2024; Ogledov: 284; Prenosov: 77
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