1791. Perioperative increase in neutrophil CD64 expression is an indicator for intra-abdominal infection after colorectal cancer surgeryMilena Kerin-Povšič, Bojana Beović, Alojz Ihan, 2017, izvirni znanstveni članek Povzetek: Colorectal surgery is associated with a high incidence of postoperative infections. Early clinical signs are difficult to distinguish from the systemic inflammatory response related to surgical trauma. Timely diagnosis may significantly improve the outcome. The objective of this study was to compare a new biomarker index CD64 for neutrophils (iCD64n) with standard biomarkers, white blood cell (WBC) count, neutrophil/lymphocyte ratio (NLR), C-reactive protein (CRP) and procalcitonin (PCT) for the early detection of postoperative infection. Methods. The prospective study included 200 consecutive patients with elective colorectal cancer surgery. Postoperative values of biomarkers from the postoperative day (POD) 1 to POD5 were analysed by the receiver operating characteristic (ROC) analysis to predict infection. The Cox regression model and the Kaplan-Meier method were used to assess prognostic factors and survival. Results. The increase of index CD64n (iCD64n) after surgery, expressed as the ratio iCD64n after/before surgery was a better predictor of infection than its absolute value. The best 30-day predictors of all infections were CRP on POD4 (AUC 0.72, 99% CI 0.61%0.83) and NLR on POD5 (AUC 0.69, 99% CI 0.57%0.80). The best 15-day predictors of organ/ space surgical site infection (SSI) were the ratio iCD64n on POD1 (AUC 0.72, 99% CI 0.58%0.86), POD3 (AUC 0.73, 99% CI 0.59%0.87) and CRP on POD3 (AUC 0.72, 99% CI 0.57%0.86), POD4 (AUC 0.79, 99% CI 0.64%0.93). In a multivariate analysis independent risk factors for infections were duration of surgery and perioperative transfusion while the infection itself was identified as a risk factor for a worse long-term survival. Conclusions. The ratio iCD64n on POD1 is the best early predictor of intra-abdominal infection after colorectal cancer surgery. CRP predicts the infection with the same predictive value on POD3.
Ključne besede: colorectal surgery, index CD64n, postoperative infection
Objavljeno v DiRROS: 10.05.2024; Ogledov: 514; Prenosov: 193
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1792. Primary pulmonary choricarcinomaŽiga Snoj, Igor Kocijančič, Erik Škof, 2017, pregledni znanstveni članek Povzetek: The aim of the study was to establish whether there are different clinical entities of primary pulmonary choriocarcinoma (PPC) that deserve different diagnostic approach and the most optimal treatment. Patients and methods. A systematic review with PubMed search was conducted to identify studies that reported cases of PPC. The eligibility criteria were histological diagnosis of pulmonary choriocarcinoma and thorough examination of the reproductive organs to exclude potential primary choriocarcinoma in the gonads. Furthermore, to illustrate the review we additionally present a patient referred at our institution. Results. 55 cases (17 men) were included in the review with a median age of 34 years. Women with the history of gestational event showed better survival outcome than women without the history of gestational event. Patients treated with combined modality treatment (surgery and chemotherapy) survived longer than the patients without combined modality treatment. Furthermore, multivariate analysis of prognostic factors showed that the combined modality treatment had independent prognostic significance. Size of the tumour showed significant prognostic influence in univariate and multivariate analysis. Conclusions. PPC is an extreme rarity with variable clinical characteristics and outcome. It is important to capture and treat patients in the early stages of the disease. Women with the history of gestational event may show better survival, therefore genetic examination could help us to predict patient%s prognosis. Surgery followed by adjuvant chemotherapy appears to represent the best treatment for PPC.
Ključne besede: choriocarcinoma, gestational event, pulmonary tumor, primary horiokarcinom
Objavljeno v DiRROS: 10.05.2024; Ogledov: 520; Prenosov: 185
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1793. Echocardiography and cardiac biomarkers in patients with non-small cell lung cancer treated with platinum-based chemotherapyDaniel Omersa, Tanja Čufer, Robert Marčun, Mitja Lainščak, 2017, izvirni znanstveni članek Povzetek: Background. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and remains an important cause of cancer death worldwide. Platinum-based chemotherapy (PBC) for NSCLC can modify outcome while the risk of cardiotoxicity remains poorly researched. We aimed to evaluate the incidence and severity of cardiac injury during PBC in patients with NSCLC and to identify patients at risk. Methods. This was a single-centre, prospective, observational study of patients with early and advanced stage NSCLC referred for PBC. In addition to standard care, patients were examined and evaluated for cardiotoxicity before the first dose (visit 1), at the last dose (visit 2) and 6 months after the last dose of PBC (visit 3). Cardiotoxicity (at visit 2 and 3) was defined as increase in the ultrasensitive troponin T, N-terminal pro-B type natriuretic peptide or decrease in left ventricular ejection fraction (LVEF). Results. Overall, 41 patients (mean age 61 +/- 9; 54% men; 68% advanced lung cancer) were included. The median number of PBC cycles was 4. During the study period, there were no incidents of heart failure, and 3 deaths caused by tumour progression were recorded. The mean values of biomarkers and LVEF did not change significantly (p > 0.20). However, 10 (25%) had cardiotoxicity which was independently associated with a history of ischemic heart disease (p = 0.026). Conclusions. In NSCLC, cardiac assessment and lifestyle modifications may be pursued in patients with a history of cardiac disease and in patients with longer life expectancy.
Objavljeno v DiRROS: 10.05.2024; Ogledov: 410; Prenosov: 270
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1795. Slovensko slovstvo v Istri pred prvo svetovno vojno : opis slovenskega knjižnega fonda pri sv. Ani v KopruDiana Košir, 2024, drugi znanstveni članki Povzetek: Knjižni fond samostanske knjižnice sv. Ane je najbolj natančno popisan v inventarni knjigi Zbirnega centra knjižnic v Portorožu (1950–1953). Samostan, ki je pred 1. sv. vojno pripadal hrvaški provinci, je v svoji knjižnici hranil tudi slovenske tiske. Prispevek prinaša pregled in besedilnozvrstni opis slovenskih del v popisu, ki kažejo na to, da so koprski frančiškani liturgične in pastoralne dejavnosti opravljali tudi v slovenščini in tako gojili domačo besedo med slovenskimi verniki, obsežen nabor posvetnega strokovno-didaktičnega gradiva pa je bil namenjen jezikovni in splošni izobrazbi.
Ključne besede: frančiškani, knjižnica Sv. Ane, p. Hijacint Repič, slovenski tisk, slovenika
Objavljeno v DiRROS: 10.05.2024; Ogledov: 344; Prenosov: 298
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1796. Discovery of 'click' 1,2,3-triazolium salts as potential anticancer drugsIvana Steiner, Nikolina Stojanović, Aljoša Bolje, Anamaria Brozović, Denis Polančec, Andreja Ambriović Ristov, Marijana Radić Stojković, Ivo Piantanida, Domagoj Eljuga, Janez Košmrlj, Maja Osmak, 2016, izvirni znanstveni članek Ključne besede: triazoles, 1, 2, 3-triazolium salts, anticancer activity, cell cycle, ROS
Objavljeno v DiRROS: 09.05.2024; Ogledov: 380; Prenosov: 225
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1800. Red blood cell transfusion and skeletal muscle tissue oxygenation in anaemic haematologic outpatientsMatej Podbregar, Ana Uršula Gavrič, Eva Podbregar, Hugon Možina, Sebastian Stefanović, 2016, izvirni znanstveni članek Povzetek: Background. Stored red blood cells (RBCs) accumulate biochemical and biophysical changes, known as storage lesion. The aim of this study was to re-challenge current data that anaemia in chronically anaemic haematology patients is not associated with low skeletal muscle tissue oxygen (StO2), and that RBC storage age does not influence the tissue response after ischaemic provocation, using near-infrared spectroscopy. Patients and methods. Twenty-four chronic anaemic haematology patients were included. Thenar skeletal muscle StO2 was measured at rest (basal StO2), with vascular occlusion testing (upslope StO2, maximum StO2) before and after transfusion. Results. Basal StO2 was low (53% +- 7%). Average RBC storage time was 10.5 +- 3.9 days. Effects of RBC transfusions were as follows: basal StO2 and upslope StO2 did not change significantly; maximum StO2 increased compared to baseline (64 +- 14% vs. 59 +- 10%, p = 0.049). Change of basal StO2, upslope StO2 and maximum StO2 was negatively related to age of RBCs. The decrease of maximum StO2 was predicted (sensitivity 70%, specificity 100%), after receiving RBCs >- 10days old. Discussion. Resting skeletal muscle StO2 in chronic anaemic patients is low. RBC storage time affects skeletal muscle StO2 in the resting period and after ischaemic provocation.
Ključne besede: skeletal muscle, transfusion, red blood cells
Objavljeno v DiRROS: 09.05.2024; Ogledov: 422; Prenosov: 254
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