941. Preoperative concomitant chemoradiotherapy in esophageal cancerBoštjan Šeruga, Mihael Sok, Janez Eržen, Jože Jerman, Boris Jančar, Branko Zakotnik, 2006, izvirni znanstveni članek Povzetek: Background. Currently primary treatment options for esophageal cancer are surgery only or concomitant chemoradiotherapy (CRT) and the long-term survivalof patients with locally advanced disease is rare. Preoperative concomitant CRT seems to be beneficial, mostly in patients who achieve a complete pathologic response (pCR) after CRT. In this retrospective analysis the efficiency and toxicity of preoperative CRT in patients with locally advanced esophageal cancer was analysed as well as the influence of pCR on thesuraival. Patients and metkods From 1996 to 2002 41 patients with locoregionally confined esophageal cancerwere treated with cisplatin 75 mgžm2 and 5-FU 1000 mgžm2 as 4 day contonuous infusion starting on days 1. and 22. with concorrtitant radiotherapy 4500 cGy, 200-300 cGyžday. Esophagectomy followed 4-5 weeks after radiotherapy. After the surgery patients were followed-up regularly at 3-6 months intervals. Results. The pCR was achieved in 26.8% of patients. The overall median survival time was 18 months for all patients, 21.2 months for patients who achieved pCR and 16 months in those with residual disease (p= 0,79). Postoperative mortality rate was 22%. The median dose intensity for cisplatin was 92% and for 5-FU 71.5 of the planned dose. Disease recurred most often locoregionally (31.7%) and the overall recurrence rate was 43.9. Conclusion. Modern radiation techniques and the adequate dose intensity could further improve the locoregional control. The selection of patients without comorbid conditions and without already present distant metastases is essential for this combined treatment approach.
Objavljeno v DiRROS: 15.02.2024; Ogledov: 244; Prenosov: 57
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942. Schedule-dependency of doxorubicin and vinblastine in EAT tumours in miceMarija Auersperg, Ana Pogačnik, Veronika Kloboves-Prevodnik, Gregor Serša, Maja Čemažar, 2006, izvirni znanstveni članek Povzetek: Background. Antitumour schedule-dependency of the doxorubicin and vinblastine combination was explored. Materials and methods. Intraperitoneal Ehrlich ascites tumours (EAT) syngeneic to CBA mice were treated with vinblastine ar doxorubicin alone, or in combined treatment schedules. Results. Combinations of doxorubicin and vinblasfine administered at 48-h, but not at 24-h interval,regardless of the sequence of drugs, significantly reduced the numberof tumour cells in the ascites in corrtparison with all other treatments. In the combined treatment schedules, the predominant morphologicalchanges as well as DNA distribution pattern were dependent on thefirst drug applied. Regardless of the sequence of the drugs, median survival times of animals did not significantly differ between the treatment groups. Conclusions. The effect of combination of vinblastine and doxorubicin is schedule-dependent. The time interval, but not the sequence of drugs seems to be crucial for the observed effect. The data from preclinical studies are important for planning combined treatment schedules in clinical setting.
Objavljeno v DiRROS: 15.02.2024; Ogledov: 184; Prenosov: 56
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943. Mixed Riemann-Hilbert boundary value problem with simply connected fibersMiran Černe, 2024, izvirni znanstveni članek Povzetek: We study the existence of solutions of mixed Riemann-Hilbert or Cherepanov boundary value problem with simply connected fibers on the unit disk $\Delta$. Let ▫$L$▫ be a closed arc on $\partial\Delta$ with the end points $\omega_{-1}, \omega_1$ and let $a$ be a smooth function on $L$ with no zeros. Let $\{\gamma_{\xi}\}_{\xi\in\partial\Delta\setminus\mathring{L}}$ be a smooth family of smooth Jordan curves in $\mathbb C$ which all contain point $0$ in their interiors and such that $\gamma_{\omega_{-1}}$, $\gamma_{\omega_{1}}$ are strongly starshaped with respect to $0$. Then under condition that for each $w\in \gamma_{\omega_{\pm 1}}$ the angle between $w$ and the normal to $\gamma_{\omega_{\pm 1}}$ at $w$ is less than $\frac{\pi}{10}$, there exists a Hölder continuous function $f$ on $\overline{\Delta}$, holomorphic on $\Delta$, such that ${\rm Re}(\overline{a(\xi)} f(\xi)) = 0$ on $L$ and $f(\xi)\in\gamma_{\xi}$ on $\partial\Delta\setminus\mathring{L}$.
Ključne besede: boundary value problems, mixed Riemann-Hilbert problem, Cherepanov problem
Objavljeno v DiRROS: 15.02.2024; Ogledov: 240; Prenosov: 116
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949. New marker of angiogenesis CD105 (endoglin): diagnostic, prognostic and therapeutic roleMateja Legan, 2005, pregledni znanstveni članek Povzetek: Background. The well established notion that malignant tumours depend on angiogenesis to grow and metastasize focused the investigators interest on tumour vasculature into visualization and validation. Panendothelial markers (CD31, CD34, F8) and CD105 are differentially expressed in angiogenic and normal vessel endothelial cells. Since the former are excellent markers for the normal vasculature, CD105 (endoglin) is more suitable for identifying tumour angiogenesis. Endoglin is a transforming growth factor (TGF)- beta binding receptor, preferentially expressed on endothelial cells of angiogenic tissues, essential for angiogenesis and vascular development. Conclusions. Tumor microvessel density expressed by CD105 immunohistochemical staining in paraffin-embedded tissue section correlates significantly with tumour aggressiveness and prognosis in many solid tumours. Also, targeting of tumour neovasculature specific antigens offers the possibility of future therapeutic approaches.
Objavljeno v DiRROS: 14.02.2024; Ogledov: 230; Prenosov: 59
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950. Small-bowel carcinoid presenting with acute bleeding detected upon wireless capsule endoscopyŽiva Mrevlje, Marko Sever, Borut Kocijančič, 2005, izvirni znanstveni članek Povzetek: Background. Intestine carcinoid usually presents with clinical symptoms and signs deriving from its endocrinological influences and rarely bleeds profusely. Case report. We present a patient with intestinal bleeding of unknown origin. After conventional diagnostic procedures only wireless capsuleendosopy was able to discover a tumour of small bowel, which was the reason of bleeding. On patohistological examination after the surgical resection it proved to be a small bowel carcinoid. Conclusions. There are indications that WCE, besides being the first small bowel imaging technique, is a very important diagnostic tool, deserving consideration in the early phases of diagnosing small-bowel disease, especially in less intensive or occult bleeding.
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