1631. Susceptibility of X17CrNi16-2 martensitic stainless steel to hydrogen embrittlement after conventional and deep cryogenic heat treatmentMirjam Bajt Leban, Bojan Zajec, Bojan Podgornik, Črtomir Donik, Patricia Jovičević Klug, Miha Hren, Andraž Legat, 2024, izvirni znanstveni članek Povzetek: A low carbon/ high chromium martensitic stainless steel, X17CrNi16-2, was heat treated using two different hardening and tempering regimes (1050 ◦ C/480 ◦ C or 980 ◦C/600 ◦C) — promoting either a high strength or high toughness state, respectively and further combined with deep cryogenic treatment (DCT) at 196 ◦C for 24 h. Over recent years DCT has been recognized as a promising technique to improve the properties of steel, predominantly with respect to its tensile strength, toughness and wear resistance. The influence of DCT on the hydrogen embrittlement resistance of martensitic stainless steel has not yet, however, been reported.
A slow strain rate tensile test (SSRT) with simultaneous cathodic hydrogen charging was selected as the method to assess potential susceptibility to hydrogen embrittlement (HE). Relatively low-intensity hydrogen charging, utilizing a constant current density of 0.1 mA/cm2, in a non-corrosive, slightly alkaline buffer solution, led to a clear reduction in the ultimate tensile stress. This reduction, and therefore the HE susceptibility, was more pronounced in the steel with a higher strength (i.e. that subject to the 1050 ◦C/ 480 ◦C heat treatment condition). Furthermore, DCT did not appear to have any impact on the steel’s mechanical properties in the presence of hydrogen. Fractographic analysis showed clear evidence of HE in the hydrogen-charged specimens.
This paper presents results of the SSRT tests and further fractography results, and discusses the impact of conventional and deep cryogenic treatment on HE susceptibility.
Ključne besede: martensitic stainless steel, deep cryogenic treatment, hydrogen embrittlement, slow strain rate tensile test
Objavljeno v DiRROS: 23.05.2024; Ogledov: 432; Prenosov: 380
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1632. Compensational role between cathepsinsUrša Pečar Fonović, Janko Kos, Ana Mitrović, 2024, pregledni znanstveni članek Povzetek: Cathepsins, a family of lysosomal peptidases, play a crucial role in maintaining cellular homeostasis by regulating protein turnover and degradation as well as many specific regulatory actions that are important for proper cell function and human health. Alterations in the activity and expression of cathepsins have been observed in many diseases such as cancer, inflammation, neurodegenerative disorders, bone remodelling-related conditions and others. These changes are not exclusively harmful, but rather appear to be a compensatory response on the lack of one cathepsin in order to maintain tissue integrity. The upregulation of specific cathepsins in response to the inhibition or dysfunction of other cathepsins suggests a fine-tuned system of proteolytic balance and understanding the compensatory role of cathepsins may improve therapeutic potential of cathepsin's inhibitors. Selectively targeting one cathepsin or modulating their activity could offer new treatment strategies for a number of diseases. This review emphasises the need for comprehensive research into cathepsin biology in the context of disease. The identification of the specific cathepsins involved in compensatory responses, the elucidation of the underlying molecular mechanisms and the development of targeted interventions could lead to innovative therapeutic approaches.
Ključne besede: lysosomal peptidases, compensation, bone resorption
Objavljeno v DiRROS: 23.05.2024; Ogledov: 356; Prenosov: 248
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