71. Mortality, seasonal variation, and susceptibility to acute exacerbation of COPD in the pandemic year : a nationwide population studyIrena Šarc, Aleša Lotrič Dolinar, Tina Morgan, Jože Sambt, Kristina Ziherl, Dalibor Gavrić, Julij Šelb, Aleš Rozman, Petra Došenović Bonča, 2022, izvirni znanstveni članek Povzetek: Background: Previous studies have suggested that the coronavirus disease 2019 (COVID-19) pandemic was associated with a decreased rate of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Data on how the COVID-19 pandemic has influenced mortality, seasonality of, and susceptibility to AECOPD in the chronic obstructive pulmonary disease (COPD) population is scarce. Methods: We conducted a national population-based retrospective study using data from the Health Insurance Institute of Slovenia from 2015 to February 2021, with 2015–2019 as the reference. We extracted patient and healthcare data for AECOPD, dividing AECOPD into severe, resulting in hospitalisation, and moderate, requiring outpatient care. The national COPD population was generated based on dispensed prescriptions of inhalation therapies, and moderate AECOPD events were analysed based on dispensed AECOPD medications. We extracted data on all-cause and non-COVID mortality. Results: The numbers of severe and moderate AECOPD were reduced by 48% and 34%, respectively, in 2020. In the pandemic year, the seasonality of AECOPD was reversed, with a 1.5-fold higher number of severe AECOPD in summer compared to winter. The proportion of frequent exacerbators (2 AECOPD hospitalisations per year) was reduced by 9% in 2020, with a 30% reduction in repeated severe AECOPD in frequent exacerbators and a 34% reduction in persistent frequent exacerbators (2 AECOPD hospitalisations per year for 2 consecutive years) from 2019. The risk of two or more moderate AECOPD decreased by 43% in 2020. In the multivariate model, pandemic year follow-up was the only independent factor associated with a decreased risk for severe AECOPD (hazard ratio [HR]: 0.71; 95% confidence interval [CI]: 0.61–0.84; p < 0.0001). In 2020, non-COVID mortality decreased (−15%) and no excessive mortality was observed in the COPD population. Conclusion: In the pandemic year, we found decreased susceptibility to AECOPD across severity spectrum of COPD, reversed seasonal distribution of severe AECOPD and decreased non-COVID mortality in the COPD population.
Ključne besede: chronic obstructive pulmonary disease -- mortality, pandemics, seasons, exacerbation, acute exacerbation, seasonal variations, population study
Objavljeno v DiRROS: 14.03.2022; Ogledov: 656; Prenosov: 369
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72. The Sistiana Fault and the Sistiana Bending Zone (SW Slovenia)Ladislav Placer, Petra Jamšek Rupnik, Bogomir Celarc, 2021, izvirni znanstveni članek Povzetek: The Sistiana Fault is an alleged disjunctive deformation of Microadria in the sea bottom of the Gulf of Trieste. Onshore, it is visible only in the Sistiana Bay, but towards the northeast it soon pinches-out, in structural-geometric terms it diminishes soon after the crossing of the thrust boundary of the Dinarides, or the Istrian-Friuli Underthrustig Zone, respectively. Further to the northeast, only the bending zone is developed in the External Dinarides, which stretches all the way from the Sistiana Bay to the Idrija-Žiri area. We named it the Sistiana Bending Zone. Its direction can be determined based on geological maps and is around 60°, so we conclude that the Sistiana Fault should extend approximately in this direction. In the bending zone, the Trieste-Komen Anticlinorium, the Vipava Synclinorium, the Trnovo Nappe opposite to the Hrušica Nappe and the Raša and Idrija Faults are laterally bent. The size of the bend is the largest in the Sistiana Bay, and in the east-northeast direction it decreases linearly. The general geological circumstances suggest that the Sistiana Fault has not been recently active.
Ključne besede: Sistiana Fault, Sistiana Bending Zone, adjusting fault, Adria Microplate, Gulf of Trieste
Objavljeno v DiRROS: 09.03.2022; Ogledov: 736; Prenosov: 393
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74. Participativni pristop pri pripravi upravljavskih načrtov na primeru izbranih gozdnih habitatnih tipov in živalskih vrst ob MuriAndreja Ferreira, Petra Grošelj, Špela Planinšek, 2021, izvirni znanstveni članek Povzetek: Evropska komisija za območja Natura 2000 priporoča izdelavo upravljavskih načrtov, ki vključujejo lokacijsko specifične cilje in na njih temelječe ukrepe ohranjanja narave. Da bi se izognili morebitnim poznejšim konfliktom, je treba v proces pravočasno in smiselno vključiti vse zainteresirane deležnike. V okviru projekta GoForMura sta bila kot vzorčni primer oblikovana upravljavska načrta za gozdni območji Natura 2000 na študijskih območjih Gornja Bistrica in Murska šuma v Prekmurju. Posebno težo v procesu nastajanja prvih tovrstnih dokumentov je imelo sodelovanje zainteresiranih deležnikov, še posebej lastnikov oz. upravljavcev gozdov.
Ključne besede: participacija, gozdnogospodarsko načrtovanje, upravljanje, Natura 2000, Mura, gozdovi, večkriterijsko odločanje, SMART
Objavljeno v DiRROS: 01.12.2021; Ogledov: 3325; Prenosov: 1977
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75. Zdravila za podporno in paliativno zdravljenjeJožica Červek, Mojca Simončič Godnič, Jernej Benedik, Maja Ebert Moltara, Jasenka Gugić Kevo, Slavica Lahajnar, Petra Tavčar, Marjana Bernot, 2021, ni določena Objavljeno v DiRROS: 16.11.2021; Ogledov: 913; Prenosov: 258
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76. Robust saliva-based RNA extraction-free one-step nucleic acid amplification test for mass SARS-CoV-2 monitoringEva Rajh, Tina Šket, Arne Praznik, Petra Sušjan, Alenka Šmid, Dunja Urbančič, Irena Mlinarič-Raščan, Polona Kogovšek, Tina Demšar, Mojca Milavec, Katarina Prosenc, Žiga Jensterle, Mihaela Zidarn, Viktorija Tomič, Gabriele Turel, Tatjana Lejko-Zupanc, Roman Jerala, Mojca Benčina, 2021, izvirni znanstveni članek Povzetek: Early diagnosis with rapid detection of the virus plays a key role in preventing the spread of infection and in treating patients effectively. In order to address the need for a straightforward detection of SARS-CoV-2 infection and assessment of viral spread, we developed rapid, sensitive, extraction-free one-step reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and reverse transcription loop-mediated isothermal amplification (RT-LAMP) tests for detecting SARS-CoV-2 in saliva. We analyzed over 700 matched pairs of saliva and nasopharyngeal swab (NSB) specimens from asymptomatic and symptomatic individuals. Saliva, as either an oral cavity swab or passive drool, was collected in an RNA stabilization buffer. The stabilized saliva specimens were heat-treated and directly analyzed without RNA extraction. The diagnostic sensitivity of saliva-based RT-qPCR was at least 95% in individuals with subclinical infection and outperformed RT-LAMP, which had at least 70% sensitivity when compared to NSBs analyzed with a clinical RT-qPCR test. The diagnostic sensitivity for passive drool saliva was higher than that of oral cavity swab specimens (95% and 87%, respectively). A rapid, sensitive one-step extraction-free RT-qPCR test for detecting SARS-CoV-2 in passive drool saliva is operationally simple and can be easily implemented using existing testing sites, thus allowing high-throughput, rapid, and repeated testing of large populations. Furthermore, saliva testing is adequate to detect individuals in an asymptomatic screening program and can help improve voluntary screening compliance for those individuals averse to various forms of nasal collections.
Ključne besede: SARS-CoV-2, COVID-19, COVID-19 serological testing, real-time polymerase chain reaction, saliva, oral cavity swab, passive drool, pooling
Objavljeno v DiRROS: 09.11.2021; Ogledov: 1137; Prenosov: 559
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77. Platforma za odprte objave znanstvenih del, financiranih v okviru programov Obzorje 2020 in Obzorje Evropa : Open Research Europe - OREMiro Pušnik, Maja Vihar, Mitja Vovk Iskrić, Petra Durini, Uroš Kunaver, 2021, druge monografije in druga zaključena dela Ključne besede: odprta znanost, znanstvene publikacije, Obzorje 2020, Obzorje Evropa, načela ORE, stroški objav
Objavljeno v DiRROS: 29.09.2021; Ogledov: 1381; Prenosov: 672
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78. The influence of land use on the spatial distribution and intensity of heat islands in SloveniaAnica Simčič, Petra Pečan, Mojca Nastran, Milan Kobal, 2021, izvirni znanstveni članek Povzetek: Heat islands (HI) are a common anthropogenic phenomenon and are defined as artificial surfaces (urban areas) that have a higher average temperature than their surroundings (rural areas). The aim of this work was to determine the influence of land use on the spatial distribution and intensity (HIi ) of HI in Slovenia. The MODIS Land Surface Temperature (LST) and Corine Land Cover (CLC) databases were used to perform the analysis. Within the identified HI, two HI levels were determined based on temperature difference. The results revealed a statistically significant negative correlation between HIi and both forest co%ver and forest fragmentation (forest edge density and ratio of mean forest patch size to HI size). Artificial surface was positively correlated with HIi . The results contribute to the understanding of the spatial distribution of HI and HIi and provide informati%on for spatial planning and policy-making to reduce the negative impact of HI.
Ključne besede: heat island, forest cover, artificial surface, forest fragmentation
Objavljeno v DiRROS: 17.08.2021; Ogledov: 3550; Prenosov: 2084
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79. Slovenska priporočila za obravnavo odraslih bolnikov s kronično odpovedjo prebavilNada Rotovnik-Kozjek, Tajda Božič, Katja Kogovšek, Borut Štabuc, Laura Petrica, Karla Berlec, Nataša Puzić Ravnjak, Erik Brecelj, Aleš Tomažič, Sanela Banović, Rada Franko, Milena Kovač-Blaž, Janez Breznik, Davorin Ćeranić, David Drobne, Mojca Gašperin, Tomaž Jurca, Maja Ebert Moltara, Rado Janša, Marjana Turk Jerovšek, Taja Jordan, Tina Kamhi, Primož Karner, Milena Kerin-Povšič, Neža Majdič, Denis Mlakar-Mastnak, Andreja Ocepek, Tadeja Pintar, Stojan Potrč, Nataša Smrekar, Monika Sonc, Maja Šeruga, Petra Tavčar, Igor Virant, 2021, strokovni članek Ključne besede: kronična odpoved prebavil, zdravljenje, onkološko zdravljenje
Objavljeno v DiRROS: 11.06.2021; Ogledov: 1378; Prenosov: 373
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