1. From causal networks to adverse outcome pathways : a developmental neurotoxicity case studyŽiva Ramšak, Vid Modic, Roman A. Li, Colette vom Berg, Anže Županič, 2022, izvirni znanstveni članek Povzetek: The last decade has seen the adverse outcome pathways (AOP) framework become one of the most powerful tools in chemical risk assessment, but the development of new AOPs remains a slow and manually intensive process. Here, we present a faster approach for AOP generation, based on manually curated causal toxicological networks. As a case study, we took a recently published zebrafish developmental neurotoxicity network, which contains causally connected molecular events leading to neuropathologies, and developed two new adverse outcome pathways: Inhibition of Fyna (Src family tyrosine kinase A) leading to increased mortality via decreased eye size (AOP 399 on AOP-Wiki) and GSK3beta (Glycogen synthase kinase 3 beta) inactivation leading to increased mortality via defects in developing inner ear (AOP 410). The approach consists of an automatic separation of the toxicological network into candidate AOPs, filtering the AOPs according to available evidence and length as well as manual development of new AOPs and weight-of-evidence evaluation. The semiautomatic approach described here provides a new opportunity for fast and straightforward AOP development based on large network resources.
Ključne besede: systems toxicology, adverse outcome pathway, casual network, toxicological network, neurotoxicity
Objavljeno v DiRROS: 16.07.2024; Ogledov: 12; Prenosov: 4
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2. Advances in the management of craniopharyngioma in children and adultsMojca Jensterle Sever, Sončka Jazbinšek, Roman Bošnjak, Mara Popović, Lorna Zadravec-Zaletel, Tina Vipotnik-Vesnaver, Barbara Faganel Kotnik, Primož Kotnik, 2019, pregledni znanstveni članek Povzetek: Childhood and adult-onset craniopharyngioma is a rare embryogenic tumor of the sellar, suprasellar, and parasellar region. Survival rates are high; however, tumor location and treatment sequalae including endocrine deficits, visual impairment, metabolic complications, cognitive and psychosocial deficits can significantly impair patient%s quality of life. There is considerable controversy regarding the optimal management of craniopharyngiomas. Subtotal resection of the tumor followed by targeted irradiation to avoid further hypothalamic damage is currently indicated. Novel insights in the tumor%s molecular pathology present the possibility for targeted therapy possibly decreasing the rate and severity of treatment-associated morbidity. Conclusions. Craniopharyngioma should be seen as a chronic disease. To achieve optimal outcomes a multidisciplinary team of specialized neurosurgeons, neuro-radiologists, neuro-oncologists, pathologists and endocrinologists should be involved in the diagnosis, planning of the surgery, irradiation and long-term follow-up.
Ključne besede: craniopharyngioma, hypopituitarism, metabolic syndrome
Objavljeno v DiRROS: 09.07.2024; Ogledov: 77; Prenosov: 40
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3. Subunits of an E3 ligase complex as degrons for efficient degradation of cytosolic, nuclear, and membrane proteinsAnže Verbič, Tina Lebar, Arne Praznik, Roman Jerala, 2024, izvirni znanstveni članek Ključne besede: synthetic biology, degrons, control of protein expression, E3 ligase
Objavljeno v DiRROS: 05.07.2024; Ogledov: 95; Prenosov: 34
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4. Vegetacijske in talne razmere v izbranih gozdovih Bele krajineValerija Babij, Aleksander Marinšek, Lado Kutnar, Peter Horvat, Andrej Držaj, Andrej Kotnik, Roman Šimic, Erika Kozamernik, 2024, elaborat, predštudija, študija Ključne besede: vegetacija, tla, rastišča, ekologija gozdov, Javna gozdarska služba, Slovenija
Objavljeno v DiRROS: 02.07.2024; Ogledov: 122; Prenosov: 43
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5. Localization patterns of cathepsins K and X and their predictive value in glioblastomaBarbara Breznik, Clara Limbaeck Stanic, Andrej Porčnik, Andrej Blejec, Miha Koprivnikar Krajnc, Roman Bošnjak, Janko Kos, Cornelis J. F. van Noorden, Tamara Lah Turnšek, 2018, izvirni znanstveni članek Ključne besede: cathepsins, glioblastoma, immunohistochemistry, patient survival, cancer stem cell niches
Objavljeno v DiRROS: 11.06.2024; Ogledov: 83; Prenosov: 26
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6. Quantitative insights on impurities in ice cores at the micro-scale from calibrated LA-ICP-MS imagingPascal Bohleber, Piers Larkman, Nicolas Stoll, David Clases, Raquel Gonzalez de Vega, Martin Šala, Marco Roman, Carlo Barbante, 2024, izvirni znanstveni članek Objavljeno v DiRROS: 10.06.2024; Ogledov: 120; Prenosov: 74
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7. Towards improved online dissolution evaluation of Pt-alloy PEMFC electrocatalysts via electrochemical flow cell - ICP-MS setup upgradesLeonard Moriau, Tina Đukić, Vojtech Domin, Roman Kodym, Martin Prokop, Karel Bouzek, Matija Gatalo, Martin Šala, Nejc Hodnik, 2024, izvirni znanstveni članek Objavljeno v DiRROS: 29.04.2024; Ogledov: 243; Prenosov: 210
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8. Early outcome in endoscopic extended endonasal approach for removal of supradiaphragmatic craniopharyngiomas : a case series and a comprehensive reviewRoman Bošnjak, Mitja Benedičič, Alenka Vittori, 2013, izvirni znanstveni članek Povzetek: Background. The choice of endoscopic expanded endonasal approach introduces the possibility of improved gross total resection of craniopharyngioma while minimizing surgical morbidity in a significant subset of patients. Methods. From our trans-sphenoidal surgical series of 331 cases, we retrospectively reviewed visual, endocrine and neuro-cognitive outcomes in the first consecutive eight patients (median age 63 years; range 4773 years) with newly diagnosed supradiaphragmatic craniopharyngioma (median tumour height 23 mm; range 1534 mm), removed by expanded endonasal approach (median follow-up 27 months; range 1069 months). Gross total resection was attempted in all patients. Results. Gross total resection was achieved in 6 of 8 patients. Visual improvement was present in 6 of 8 patients of patients or in 14 of 16 eyes. New endocrinopathy, including diabetes insipidus, appeared in 5 of 8 patients. Stalk was preserved in 4 patients. Cognitive decline was present in 2 cases. Five of 8 patients retained previous quality of life. Conclusions. Our early outcome results are comparable to the recent few expanded endonasal approach series, except for the incidence of new endocrinopathy and cerebrospinal fluid leak rate. This was influenced by higher number of transinfundibular tumours in our series, where stalk preservation is less likely, and not using nasoseptal flap or gasket closure in the first half of cases. Including data from the literature and ours, expanded endonasal approach shows a trend for improved gross total resection rate with less morbidity, more obviously for visual outcome and quality of life than for endocrine outcome. However, validity of expanded endonasal approach should be confirmed in a larger number of patients with a longer follow-up period.
Objavljeno v DiRROS: 22.03.2024; Ogledov: 203; Prenosov: 54
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9. Roles of the reference service life (RSL) of buildings and the RSL of building components in the environmental impacts of buildingsTajda Potrč Obrecht, Roman Kunič, Sabina Jordan, Andraž Legat, 2019, objavljeni znanstveni prispevek na konferenci Povzetek: The Life Cycle Assessment of a building is a complex analysis that also involves the use of the predicted Reference Service Life (RSL) of the building components and materials, as well as the predicted RSL of the whole building. The RSL values of individual materials and building components can be obtained from different sources and are not exactly comparable. In the present study, the influence of selected RLS values on an LCA assessment was evaluated. Three different RSL databases were used as the sources of the data to estimate the environmental impacts of selected building components (internal wooden door and external finishing coat). Two scenarios were presented. In the first scenario a building component can be reused in another building, while in the second scenario the reuse of the building component is not possible. The study showed that dependent on the selected RSL database, the results can differ by up to a factor of five. Therefore, it is very important to describe clearly the maintenance scenarios for a building in order to have a reliable comparison of the results of LCA assessments.
Ključne besede: reference service life, life cycle assessment, refurbishment
Objavljeno v DiRROS: 08.03.2024; Ogledov: 271; Prenosov: 183
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10. Small cellular particles from European spruce needle homogenateMarko Jeran, Anna Romolo, Vesna Spasovski, Matej Hočevar, Urban Novak, Roman Štukelj, Vid Šuštar, Matic Kisovec, Apolonija Bedina Zavec, Ksenija Kogej, Aleš Iglič, Polonca Trebše, Veronika Kralj-Iglič, 2023, izvirni znanstveni članek Ključne besede: Picea abies, spruce needles, extracellular particles, extracellular vesicles, small cellular particles, interferometric light microscopy, exosomes, cell-to-cell communication, drug delivery
Objavljeno v DiRROS: 07.02.2024; Ogledov: 318; Prenosov: 182
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