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Povzetek: Research on the metabolic physiology of groundwater species, particularly regarding oxygen consumption rates (OCR), has made significant advancement, revealing valuable insights into the adaptations of exclusively groundwater-dwelling (stygobitic) species. However, a comprehensive understanding of how these metabolic rates scale with body mass and respond to temperature changes remains elusive. This study aims to bridge this gap by reviewing published data on OCR across a variety of groundwater organisms to elucidate patterns of metabolic rates in relation to body size and temperature. We employed a combination of literature review and quantitative analyses, focusing on the allometric scaling of OCR with body weight and the effect of temperature on metabolic rates. Our findings indicate that OCR scales with body weight in an allometric pattern, with an inter-species slope of 0.80, suggesting non-isometric scaling. Furthermore, our analysis showed that stygobitic species’ metabolic rates are less responsive to warming than those of non-stygobitic species at low to moderate temperatures. However, at higher temperatures, metabolic rates in stygobitic species decline faster than in non-stygobitic taxa, highlighting a potential vulnerability to global climate change. This study contributes to our understanding of the metabolic strategies of groundwater species, underscoring the need for further research to fully grasp the eco-evolutionary implications of these findings for groundwater conservation.
Ključne besede: allometry, Arrhenius equation, ectotherms, metabolism, oxygen consumption rate, respiration, stygobiont
Objavljeno v DiRROS: 13.09.2024; Ogledov: 228; Prenosov: 131
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Povzetek: V članku je predstavljena črnika (Quercus ilex L.), ena glavnih drevesnih vrst evmediteranske flore na območju Slovenije, kjer raste na razpršenih nahajališčih na severni meji svojega naravnega areala. Glavni namen raziskave je bil preučiti morfološko variabilnost njenih listov. V raziskavo je bilo vključenih sedem naravnih populacij črnike v Sloveniji. Morfometrijska analiza je pokazala veliko variabilnost listov in značilne razlike med populacijami, ki smo jih potrdili pri skoraj vseh preučevanih morfoloških znakih. Na podlagi ugotovljenih morfoloških razlik lahko slovenske populacije razdelimo v tri geografskomorfološke skupine: i) populacije na Goriškem (Sabotin, Sv. Gora in Lijak), ii) Nanos - Osp in iii) populaciji v dolini reke Dragonje. Morfološka variabilnost kot odsev genetske variabilnosti je posledica prilagoditve na lokalne okoljske razmere. Črnika v Sloveniji za zdaj ni ogrožena vrsta, vendar bi bilo pri morebitnih aktivnih varstvenih ukrepih za njeno ohranjanje smiselno čimbolj upoštevati ugotovljene tri geografsko-morfološke skupine.
Ključne besede: črnika, Quercus ilex, morfološka variabilnost, Slovenija, drevesni listi
Objavljeno v DiRROS: 12.09.2024; Ogledov: 594; Prenosov: 691
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Povzetek: This book is the seventh volume in the ECOTHEE book series, which is published every two years and was first published in the field of ecumenical ecotheology in 2008, following the first ECOTHEE conference (ECOTHEE 08) held in Crete on the occasion of World Environment Day on June 5, 2008. Each ECOTHEE publication collects academic papers and statements by scientists, theologians, sociologists and researchers from different fields under the motto: “Religion and science can provide solutions to sustainability problems.” The articles selected in this seventh volume, ECOTHEE 22, continue the development of ecotheological resources on environmental ethics and sustainable solutions for the common oikos. This book follows the ECOTHEE goal and seeks to engage theology on key ecological concerns from a variety of religious traditions and perspectives. The emphasis is on theological and ethical implications of contributing to a sustainable ecological future. This publication is enriched with additional articles from the 5th SAPREJ conference on sustainable alternatives to poverty reduction and eco-justice and the roles, responsibilities and initiatives of religion, science and civil societies for ecological justice and biodiversity protection, held in Addis Ababa, Ethiopia, in May 2023. /// The present ECOTHEE 22 book is structured into the following sections: Introduction, Section 1: Towards Reconciliation and Justice for all Creation (Eco-ethical Theological and Philosophical Reflections), Section 2: Governance, Politics, Good Practices, and Critical Evaluations of Ecological (In)Justice. /// An “Anthology of Contemporary Ecotheology, Philosophy and Eco-Justice Practices” volume of ECOTHEE delivers chapters on contemporary insights into various religious, spiritual, philosophical reflections towards reconciliation and ecojustice for a sustainable future.
Objavljeno v DiRROS: 11.09.2024; Ogledov: 461; Prenosov: 1528
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Povzetek: Glioblastoma (GB) is the most common primary malignant brain tumor, characterized by resistance to therapy. Despite aggressive treatment options, GB remains an incurable disease. Invasiveness and heterogeneity are key GB features that cannot be studied in preclinical in vitro models. In this study, we investigated the effects of standard therapy using patient-derived GB organoids (GBOs). GBOs reflect the complexity and heterogeneity of the original tumor tissue. No significant effect on GBO viability or invasion was observed after irradiation and temozolomide treatment. E3 ubiquitin-protein ligase (MDM2), cyclin-dependent kinase inhibitor 1A (CDKN1A), and the serine/threonine kinases ATM and ATR were upregulated at the gene and protein levels after treatment. Our results show that the p53 pathway and DNA-damage response mechanisms were triggered, suggesting that GBOs recapitulate GB therapy resistance. GBOs thus provide a highly efficient platform to assess the specific responses of GB patients to therapy and to further explore therapy resistance.
Ključne besede: cellular physiology, cellular toxicology, in vitro toxicology including 3D culture, technical aspects of cell biology, cancer
Objavljeno v DiRROS: 09.09.2024; Ogledov: 360; Prenosov: 166
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Objavljeno v DiRROS: 09.09.2024; Ogledov: 321; Prenosov: 4006
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