1. Tartary buckwheat flavonoids improve colon lesions and modulate gut microbiota composition in diabetic miceWenwen Cheng, Cifeng Cai, Ivan Kreft, Tamara Lah Turnšek, Mingyan Zu, Yongping Hu, Meiliang Zhou, Zhiyong Liao, 2022, izvirni znanstveni članek Povzetek: Tartary buckwheat flavonoids (TBFs) exhibit diverse biological activities, with antioxidant, antidiabetes, anti-inflammatory, and cholesterol-lowering properties. In this study, we investigated the role of TBFs in attenuating glucose and lipid disturbances in diabetic mice and hence preventing the occurrence of diabetes-related colon lesions in mice by regulating the gut microbiota. The results showed that TBFs (1) reversed blood glucose levels and body weight changes; (2) improved levels of serum total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and fasting insulin; and (3) significantly reduced diabetes-related colon lesions in diabetic mice. In addition, TBFs also affected the diabetes-related imbalance of the gut microbiota and enriched beneficial microbiota, including Akkermansia and Prevotella. The TBF also selectively increased short-chain fatty acid-producing bacteria, including Roseburia and Odoribacter, and decreased the abundance of the diabetes-related gut microbiota, including Escherichia, Mucispirillum, and Bilophila. The correlation analysis indicated that TBFs improved metabolic parameters related to key communities of the gut microbiota. Our data suggested that TBFs alleviated glucose and lipid disturbances and improved colon lesions in diabetic mice, possibly by regulating the community composition of the gut microbiota. This regulation of the gut microbiota composition may explain the observed effects of TBFs to alleviate diabetes-related symptoms.
Ključne besede: Tartary buckwheat, flavonoids, microbiota, mice
Objavljeno v DiRROS: 17.07.2024; Ogledov: 52; Prenosov: 43
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2. Differences in ratio of carbon stable Isotopes among barley grain milling fractions with various concentrations of beta-glucansTom Levanič, Blaž Cigić, Mateja Germ, Ivana Polišenská, Kateřina Vaculová, Igor Pravst, Darja Kocjan Ačko, Ivan Kreft, 2023, izvirni znanstveni članek Povzetek: The grains of three barley varieties were milled and sieved to obtain respective milling fractions with a content of beta-glucans (b-G) from 1.4 to 10.7%. The enriched fraction obtained by the extraction and precipitation contained 24.7% of b-G. The differences between the ratio of stable C carbon isotopes were established. Milling fractions with coarse particles had more beta-glucans and a more negative ratio of δ 13C isotope in comparison to the respective intact barley grain. However, the enriched fraction had a less negative isotope ratio. So, it is not expected that the deviation from the stable isotope ratio of grain in milling fractions is the result of the content of b-G, but it depends on other barley grain constituents. In different parts of barley grain, there are substances with different stable isotope ratios, and by milling and sieving, they are assorted to the same milling fraction with most of the b-G. The method for determining the ratio of a stable carbon isotope in diverse barley grain fractions, applied in this investigation, is potentially opening the possibility for an additional method of screening the concentration of bioactive constituents in barley grain.
Ključne besede: beta-glucans, starch, barley, stable isotopes, nutrition, milling
Objavljeno v DiRROS: 02.08.2023; Ogledov: 558; Prenosov: 264
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4. Genetska diferenciacija avtohtonih populacij smreke (Picea abies (L.) Karst.) v Sloveniji, ugotovljena z analizo izoencimovGregor Božič, Monika Konnert, Mitja Zupančič, Hojka Kraigher, Ivan Kreft, 2003, izvirni znanstveni članek Povzetek: Raziskava obravnava genetsko diferenciacijo 22 populacij smreke (Picea abies (L.) Karst.) z njenih naravnih rastišč v Sloveniji in 4 na Hrvaškem z analizo izoencimskih genskih označevalcev. Razlike med populacijami smo ocenili z genetskimi razdaljami po Gregoriusu (1974) za 15 polimorfnih genskih lokusov. Vrednosti genetskih razdalj se gibljejo med 0,021 in 0,073 (v Sloveniji do 0,063). Izoencimska genetska diferenciranost smreke je razmeroma majhna. Rezultati hierarhične klasifikacije nakazujejo geografsko odvisno združevanjepopulacij v dve skupini: alpsko skupino s Trnovskim gozdom in osrednje dinarsko skupino. Skupini se na območju Snežnika tudi prekrivata.
Ključne besede: Picea abies (L.) Karst, izoencimi, genetska diferenciacija, varstvo gozdnih genskih virov, Slovenija, Hrvaška
Objavljeno v DiRROS: 12.07.2017; Ogledov: 4573; Prenosov: 2110
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9. Gene - nutrition interaction and plant metabolites in the treatment of human hereditary based disordersIvan Kreft, Sayoko Ikeda, Kiyokazu Ikeda, Vida Škrabanja, Giovanni Bonafaccia, 1997, objavljeni znanstveni prispevek na konferenci (vabljeno predavanje) Ključne besede: genetic polymorphism, allergies, carcinogenesis, cardio-vascular diseases, errors of metabolism
Objavljeno v DiRROS: 12.07.2017; Ogledov: 2813; Prenosov: 776
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