1. Milestone M27 : user friendly data management and analysis environment for plant systems biology established and novel/improved multiomics data visualisation tool availableLuka Ausec, Barbara Jenko Bizjan, Janez Kokošar, Amrita Roy Choudhury, Miha Štajdohar, Kristina Gruden, Maja Križnik, Marko Petek, Živa Ramšak, 2018, končno poročilo o rezultatih raziskav Povzetek: We present the technical report regarding the implementation of the Genialis Platform at the National Institute of Biology (NIB) within the project Hyp (J4-7636). Objavljeno v DiRROS: 05.09.2024; Ogledov: 93; Prenosov: 76 Celotno besedilo (521,13 KB) Gradivo ima več datotek! Več... |
2. Breast size and dose to cardiac substructures in adjuvant three-dimensional conformal radiotherapy compared to tangential intensity modulated radiotherapyIvica Ratoša, Aljaša Jenko, Željko Šljivić, Maja Pirnat, Irena Oblak, 2020, izvirni znanstveni članek Povzetek: The aim of the study was to quantify planned doses to the heart and specific cardiac substructures in free-breathing adjuvant three-dimensional radiation therapy (3D-CRT) and tangential intensity modulated radiotherapy (t-IMRT) for left-sided node-negative breast cancer, and to assess the differences in planned doses to organs at risk according to patients% individual anatomy, including breast volume. Patients and methods. In the study, the whole heart and cardiac substructures were delineated for 60 patients using cardiac atlas. For each patient, 3D-CRT and t-IMRT plans were generated. The prescribed dose was 42.72 Gy in 16 fractions. Patients were divided into groups with small, medium, and large clinical target volume (CTV). Calculated dose distributions were compared amongst the two techniques and the three different groups of CTV. Results. Mean absorbed dose to the whole heart (MWHD) (1.9 vs. 2.1 Gy, P < 0.005), left anterior descending coronary artery mean dose (8.2 vs. 8.4 Gy, P < 0.005) and left ventricle (LV) mean dose (3.0 vs. 3.2, P < 0.005) were all significantly lower with 3D-CRT technique compared to t-IMRT. Apical (8.5 vs. 9.0, P < 0.005) and anterior LV walls (5.0 vs. 5.4 Gy, P < 0.005) received the highest mean dose (Dmean). MWHD and LV-Dmean increased with increasing CTV size regardless of the technique. Low MWHD values (< 2.5 Gy) were achieved in 44 (73.3%) and 41 (68.3%) patients for 3D-CRT and t-IMRT techniques, correspondingly. Conclusions. Our study confirms a considerable range of the planned doses within the heart for adjuvant 3D-CRT or t-IMRT in node-negative breast cancer. We observed differences in heart dosimetric metrics between the three groups of CTV size, regardless of the radiotherapy planning technique. Ključne besede: breast cancer, radiotherapy, 3D-CRT Objavljeno v DiRROS: 16.07.2024; Ogledov: 202; Prenosov: 108 Celotno besedilo (544,83 KB) |
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4. Characterization of micro-threaded stem taper surface of cementless hip endoprosthesesDrago Dolinar, Boštjan Kocjančič, Klemen Avsec, Barbara Šetina, Aleksandra Kocijan, Matjaž Godec, Marko Sedlaček, Mojca Debeljak, John T. Grant, Timon Zupanc, Monika Jenko, 2024, izvirni znanstveni članek Povzetek: We investigated micro-threaded stem taper surface and its impact on premature failures, aseptic loosening, and infection in cementless hip endoprostheses. Our study focused on the fretting, and crevice corrosion of micro-threaded tapers, as well as the characterization of the microstructure and surface properties of two new and three retrieved Zweymüller stem tapers. The retrieved samples were selected and examined based on the head–stem taper interface being the sole source of modularity with a metallic component, specifically between the Ti alloy taper stem and the ceramic head. To determine the surface chemistry and microstructures of both new and retrieved hip endoprostheses stem taper titanium alloy, scanning -electron microscopy (SEM) was employed for morphological and microstructural analyses. Energy dispersive spectroscopy (EDS) was utilized for characterizing chemical element distribution, and electron backscattered diffraction (EBSD) was used for phase analysis. The roughness of the micro-threated stem tapers from different manufacturers was investigated using an optical profilometer, with standard roughness parameters Ra (average surface roughness) and Rz (mean peak to valley height of the roughness profile) being measured. Electrochemical studies revealed no fretting corrosion in retrieved stem tapers with ceramic heads. Consequently, three retrieved tapers and two new ones for comparison underwent potentiodynamic measurements in Hank’s solution to determine the corrosion rate of new and retrieved stem taper surfaces. The results showed a low corrosion rate for both new and prematurely failed retrieved samples due to aseptic loosening. However, the corrosion rate was higher in infected and low-grade infected tapers. In conclusion, our study suggests that using ceramic heads reduces taper corrosion and subsequently decreases the incidence of premature failures in total hip arthroplasty. Ključne besede: total hip arthroplasty, stem micro-threaded taper, taper surface morphology, microstructure, corrosion, Ti implant alloy Objavljeno v DiRROS: 06.06.2024; Ogledov: 272; Prenosov: 237 Celotno besedilo (8,47 MB) Gradivo ima več datotek! Več... |
5. Sinonasal inverted papilloma associated with squamous cell carcinomaJasna But-Hadžić, Klemen Jenko, Mario Poljak, Boštjan Kocjan, Nina Gale, Primož Strojan, 2011, izvirni znanstveni članek Ključne besede: rak (medicina), papiloma virusi, nosna votlina, karcinom, zdravljenje, radioterapija Objavljeno v DiRROS: 18.03.2024; Ogledov: 418; Prenosov: 115 Celotno besedilo (513,64 KB) |
6. Development of the recycling procedure for rapid antigen testsRebeka Rudolf, Darja Feizpour, Žiga Jelen, Peter Majerič, Tilen Švarc, Matej Zadravec, Timi Gomboc, Aleksandra Kocijan, 2024, izvirni znanstveni članek Ključne besede: rapid antigen tests, recycling, characterization, nanogold, plastic Objavljeno v DiRROS: 28.02.2024; Ogledov: 437; Prenosov: 196 Celotno besedilo (1,74 MB) Gradivo ima več datotek! Več... |
7. Stereotaktična radioterapija za zdravljenje refraktarne prekatne tahikardije: prikaz primerovTamara Jarm, Krištof Knap, Bor Antolič, Boštjan Berlot, Rihard Hudej, Aljaša Jenko, Ajra Šečerov Ermenc, Jasna But-Hadžić, Ivica Ratoša, 2023, strokovni članek Povzetek: Stereotaktična radioterapija aritmij (STAR) predstavlja novo in obetavno možnost za bolnike z refraktarno prekatno tahikardijo, ki je odporna proti konvencionalnim metodam zdravljenja. STAR omogoča natančno neinvazivno ablacijo aritmogenega substrata ob minimalni prizadetosti sosednjih organov. Ta metoda zdravljenja je uporabna za bolnike, pri katerih je tarčno tkivo s katetrsko ablacijo nedosegljivo, pogosti šoki implantabilnega kardioverter-defibrilatorja pa močno nižajo njihovo kakovost življenja ali kadar sta ti metodi zdravljenja zaradi slabega zdravstvenega stanja kontraindicirani. Tarčo obsevanja (predel levega prekata) natančno opredelimo s predhodno slikovno diagnostiko, elektrokardiogramom, posnetki prekatne tahikardije in po potrebi invazivnim ali neinvazivnim elektrofiziološkim mapiranjem srca. Po pripravi na obsevanje na simulatorju sledi enkratno obsevanje z visokim odmerkom 25 Gy, ki je trenutno edina standardna frakcionacija. Bolniki obsevanje dobro prenašajo. Dosedanje raziskave so poročale o dobri učinkovitosti zdravljenja z bistvenim zmanjšanjem pogostosti epizod prekatne tahikardije in brez večjih neželenih učinkov. Poročamo o prvi skupini štirih bolnikov z visokorizično refraktarno prekatno tahikardijo, ki so bili zdravljeni s stereotaktično radioterapijo na Onkološkem inštitutu Ljubljana. Izvedba STAR se je izkazala kot učinkovita metoda z nizko stopnjo akutnih neželenih učinkov in predstavlja novo možnost obravnave te ranljive skupine bolnikov v slovenskem prostoru. Ključne besede: stereotaktična radioterapija, aritmije, prekatna tahikardija, radioablacija srca Objavljeno v DiRROS: 26.02.2024; Ogledov: 423; Prenosov: 106 Celotno besedilo (146,07 KB) |
8. Mechanisms of premature fracture in modular neck stems made of CoCrMo/Ti6Al4V and Ti6Al4V/Ti6Al4V alloyDrago Dolinar, Miro Gorenšek, Klemen Avsec, Barbara Šetina, Matej Hočevar, Matjaž Godec, Borut Žužek, Mojca Debeljak, Monika Jenko, John T. Grant, Boštjan Kocjančič, 2023, izvirni znanstveni članek Povzetek: In this paper, we present the mechanisms of premature fracture of modular neck stems in two case studies: (I) when the neck and stem are both made of the same Ti6Al4V alloy, and (II) when the neck and stem are made from two different alloys, CoCrMo and Ti6Al4V alloy. Our study integrates two orthopedic patients who have undergone primary uncemented THA for usual indications in two orthopedic centers (Community Health Centre and University Medical Centre). Both centers are part of the national public health care system. Both surgeries were performed by two skilled orthopedic surgeons with more than 10 years of experience in THA. The survivorship of the modular neck of cast CoCrMo alloy was 24 months. The survivorship of the modular neck from Ti6Al4V alloy was 84 months. Multivariate analyses were performed to assess the differences in the fretting, corrosion, and fatigue of the two prematurely failed modular neck stems: stereo light microscopy (SLM), scanning electron microscopy (SEM), X-ray energy-dispersive spectroscopy (EDS), and electron backscatter diffraction (EBSD). Patient demographic information, including sex, age, body mass index, survivorship of implants, and reason for the revision, was collected from medical records. We found that fretting and fatigue occurred on both neck-stem retrievals due to additional galvanic corrosion, but the CoCrMo/Ti6Al4V alloy system suffered more corrosion due to additional galvanic corrosion and fractured earlier than the Ti6Al4V/Ti6Al4V metal alloy system. Both metallic alloy systems used in this application are known to be highly corrosion-resistant, but the bio-tribo-corrosion processes need to be understood in detail and characterized so that appropriate improvements in design and materials can be made. Ključne besede: total hip arthroplasty, modular neck, Ti6Al4V alloy, CoCrMo alloy, corrosion Objavljeno v DiRROS: 07.02.2024; Ogledov: 523; Prenosov: 280 Celotno besedilo (5,12 MB) Gradivo ima več datotek! Več... |
9. Evaluation of the impact and fracture toughness of a nanostructured bainitic steel with low retained austenite contentMihael Brunčko, Peter Kirbiš, Ivan Anžel, Leo Gusel, Darja Feizpour, Tomaž Irgolič, Tomaž Vuherer, 2023, izvirni znanstveni članek Ključne besede: evaluation of fracture toughness, impact toughness, nanostructured bainite, natural aging, low retained austenite content, kinetically activated bainite KAB Objavljeno v DiRROS: 02.02.2024; Ogledov: 460; Prenosov: 209 Celotno besedilo (6,44 MB) Gradivo ima več datotek! Več... |
10. Inflammatory, oxidative stress and small cellular particle response in HUVEC induced by debris from endoprosthesis processingZala Jan, Matej Hočevar, Veno Kononenko, Sara Michelini, Neža Repar, Maja Caf, Boštjan Kocjančič, Drago Dolinar, Slavko Kralj, Darko Makovec, Aleš Iglič, Damjana Drobne, Monika Jenko, Veronika Kralj-Iglič, 2023, izvirni znanstveni članek Ključne besede: endoprosthesis failure, corundum, cytokines, reactive oxygen species, lipid droplets Objavljeno v DiRROS: 02.02.2024; Ogledov: 559; Prenosov: 227 Celotno besedilo (4,34 MB) Gradivo ima več datotek! Več... |