21. Long term outcome after combined modality treatment for anal cancerIrena Oblak, Primož Petrič, Franc Anderluh, Vaneja Velenik, Albert-Peter Fras, 2012, izvirni znanstveni članek Povzetek: Background. The aim of the retrospective study was to evaluate the effectiveness and toxicity of radiochemotherapy in patients with squamous cellcarcinoma of the anal canal treated at a single institution. Patients and methods. Between 1/2003 and 9/2010, 84 patients were treated with radical radiochemotherapy at the Institute of Oncology Ljubljana, Slovenia. The treatment consisted of 3-dimensional conformal external beam radiotherapy with concurrent chemotherapy (5-fluorouracil and mytomycin C), followed by brachytherapy or external beam boost. The toxicity of therapy and its effectiveness were assessed. Results. The treatment was completed according tothe protocol in 79.8% of patients. The median follow-up time of 55 survivors was 53 months (range: 16-105 months). The 5-year locoregional control(LRC), disease-free survival (DFS), disease-specific survival (DSS), overall survival (OS) and colostomy-free survival (CFS) rates were 71%, 68%, 81%, 67% and 85%, respectively. No treatment-related mortality was observed. The most frequent acute side-effect of the treatment was radiodermatitis (grade 3-4 in 58.2% of patients). LENT-SOMA grade 3-4 late radiation side effects were observed in 15 (18%) patients. In patients with brachytherapy boost a trend of less late side effects was observed compared to patients with external beam boost (P=0.066). On multivariate analysis, complete clinicaldisease response was identified as an independent prognostic factor for LRC, DFS and DSS, the salvage surgery for LRC and DFS, whereas Hb below 120 g/l retained its independent prognostic value for OS. Conclusions. Radiochemotherapy provides an excellent disease control and the survival with preserving anal sphincter function in majority of patients. Surgical salvage with abdominoperineal resection for persistent or recurrent disease has curative potential.
Objavljeno v DiRROS: 21.03.2024; Ogledov: 150; Prenosov: 48
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22. CD133/prominin1 is prognostic for GBM patient's survival, but inversely correlated with cysteine cathepsine' expression in gliobastoma derived spheroidsSeyed Yousef Ardebili, Irena Zajc, Boris Gole, Benito Campos, Christel Herold-Mende, Sara Drmota Prebil, Tamara Lah Turnšek, 2011, izvirni znanstveni članek Povzetek: Introduction. CD133 is a marker for a population of glioblastoma (GBM) and normal neural stem cells (NNSC). We aimed to reveal whether the migratory potential and differentiation of these stem cells is associated with CD133 expression and with cathepsin proteases (Cats). Materials and methods. The invasiveness of normal NNSC, GBM/CD133+ cell lines and GBM spheroids was evaluated in 3D collagen, as well as of U87-MG and normal astrocytes (NHA) grown in monolayers in 2D Matrigel. Expression of Cats B, L and S was measuredat mRNA and activity levels and their relation to invasiveness, to CD133 mRNA in 26 gliomas, and to the survival of these patients. Results. The average yield of CD133+ cells from GBM samples was 9.6%. Survival of patients with higher CD133 mRNA expression was significantly shorter (p< 0.005). Invasion, associated with proteolytic degradation of matrix, was higher in normal stem cells and GBM spheroids and cells than in isolated GBM CD133+ cells. In glioma samples, there was no correlation between CD133 mRNA expression and Cat mRNAs, but there was an inverse correlation with Cat activities. Conclusions. The study confirms CD133 as a prognostic marker for the survival of GBM patients. We demonstrated that NNSC have higher invasion potential and invade the collagen matrix in a mode different from that of GBM,initiating stem cell spheres. This result could have implications for the design of new therapeutics, including protease inhibitors that specifically target invasive tumour stem cells. Increased activity of cathepsins in CD133- cells suggests their role in the invasive behaviour of GBM.
Objavljeno v DiRROS: 19.03.2024; Ogledov: 171; Prenosov: 37
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27. Postoperative radiochemotherapy for gastric adenocarcinoma : long term resultsIrena Oblak, Franc Anderluh, Vaneja Velenik, 2009, izvirni znanstveni članek Povzetek: Background. To analyze the efficacy of postoperative radiochemotherapy with 5-florouracil (5-FU) and leucovorin (LV) applied in the patients with gastric carcinoma treated in a single institution. Patients and methods. Between 2001 and 2004, 123 patients with resected gastric adenocarcinoma were treated with postoperative concomitant radiochemotherapy with 5-FU and LV. The adjuvant treatment consisted of five cycles of chemotherapy with 5-FU (425mg/m2 IV) andLV (20 mg/m2 IV) and concomitant radiotherapy with the total dose of 45 Gy.Results. The treatment was completed according to the protocol in 82% of patients. The frequency and severity of early toxic effects induced by radiochemotherapy were manageable. Median follow-up time of 56 survivors was 64.5 months (range: 51.7-96.4 months). The 5-year locoregional control (LRC), diseasefree survival (DFS), disease-specific survival (DSS) and overall survival (OS) were 81%, 48.3%, 50.4%, and 48.4%, respectively. The multivariate analysis showed that the tumor involvement of cardia and low intensity of chemotherapy were independent adverse prognostic factors for DSS and OS. More advanced pT-stage and tumors with diffuse growth type according to Lauren were identified as negative independent prognostic factor for OS. They were also on the threshold of statistical significance for DSS. Conclusions. Postoperative radiochemotherapy for gastric carcinoma has acceptable toxicity, and is effective particularly in regard to LRC. High incidence of distant metastases calls for more effective systemic regimens.
Objavljeno v DiRROS: 08.03.2024; Ogledov: 154; Prenosov: 38
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28. Relevance of cold-rolling technology for the texture and anisotropy of EN AW-8011A aluminum alloysJakob Kraner, Kyung Il Kim, Bonghwan Kim, Shae K. Kim, Irena Paulin, 2023, izvirni znanstveni članek Ključne besede: aluminium alloys, cold rolling, SEM-EBSD, textures, anisotropy
Objavljeno v DiRROS: 08.03.2024; Ogledov: 164; Prenosov: 77
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30. High temperature oxidation of EN AW 7075 aluminium alloyNejc Velikajne, Tilen Balaško, Jaka Burja, Matjaž Godec, Irena Paulin, 2024, objavljeni znanstveni prispevek na konferenci Povzetek: Aluminium alloys are highly valued for their exceptional strength-to-weight ratio, making them a preferred choice in structural applications. Among these alloys, EN AW 7075 stands out for its superior mechanical properties, finding widespread use in industries such as aerospace, mechanical engineering, and sports equipment. This study investigates the high-temperature oxidation behavior of EN AW 7075 alloy. The gathered results can provide valuable insights into the behavior of the mentioned alloy during the selective laser melting (SLM) process. These results can contribute to a better understanding of how the alloy responds to specific conditions and parameters. SLM is an additive manufacturing technique. The process involves the sequential steps of preheating, melting, and rapid cooling of metal powder. To minimize the influence of oxygen, the build chamber is filled with inert gas. A protective argon atmosphere is continuously maintained. However, despite these precautions, oxidation can still occur, leading to potential issues in the final product. Hence, we examined the oxidation kinetics of the EN AW 7075 alloy in an oxygen atmosphere in the temperature range of 300-500 °C. The findings of this investigation significantly contribute to an understanding of the behavior of the alloy during high-temperature oxidation, particularly for ongoing studies focused on processing Al-Zn-Mg-Cu alloys using the selective laser melting technique. Thermogravimetry was employed to analyze the oxidizing behavior, with three samples subjected to a 6-hour exposure in an oxidizing atmosphere at temperatures of 300, 400, and 500 °C. Surprisingly, no oxidation occurred, as indicated by the negligible and negative changes in mass observed across all samples.
Ključne besede: EN AW 7075, high-temperature oxidation, oxide film, selective laser melting
Objavljeno v DiRROS: 28.02.2024; Ogledov: 212; Prenosov: 84
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