1881. Schedule-dependency of doxorubicin and vinblastine in EAT tumours in miceMarija Auersperg, Ana Pogačnik, Veronika Kloboves-Prevodnik, Gregor Serša, Maja Čemažar, 2006, izvirni znanstveni članek Povzetek: Background. Antitumour schedule-dependency of the doxorubicin and vinblastine combination was explored. Materials and methods. Intraperitoneal Ehrlich ascites tumours (EAT) syngeneic to CBA mice were treated with vinblastine ar doxorubicin alone, or in combined treatment schedules. Results. Combinations of doxorubicin and vinblasfine administered at 48-h, but not at 24-h interval,regardless of the sequence of drugs, significantly reduced the numberof tumour cells in the ascites in corrtparison with all other treatments. In the combined treatment schedules, the predominant morphologicalchanges as well as DNA distribution pattern were dependent on thefirst drug applied. Regardless of the sequence of the drugs, median survival times of animals did not significantly differ between the treatment groups. Conclusions. The effect of combination of vinblastine and doxorubicin is schedule-dependent. The time interval, but not the sequence of drugs seems to be crucial for the observed effect. The data from preclinical studies are important for planning combined treatment schedules in clinical setting. Objavljeno v DiRROS: 15.02.2024; Ogledov: 297; Prenosov: 74
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1882. Mixed Riemann-Hilbert boundary value problem with simply connected fibersMiran Černe, 2024, izvirni znanstveni članek Povzetek: We study the existence of solutions of mixed Riemann-Hilbert or Cherepanov boundary value problem with simply connected fibers on the unit disk $\Delta$. Let ▫$L$▫ be a closed arc on $\partial\Delta$ with the end points $\omega_{-1}, \omega_1$ and let $a$ be a smooth function on $L$ with no zeros. Let $\{\gamma_{\xi}\}_{\xi\in\partial\Delta\setminus\mathring{L}}$ be a smooth family of smooth Jordan curves in $\mathbb C$ which all contain point $0$ in their interiors and such that $\gamma_{\omega_{-1}}$, $\gamma_{\omega_{1}}$ are strongly starshaped with respect to $0$. Then under condition that for each $w\in \gamma_{\omega_{\pm 1}}$ the angle between $w$ and the normal to $\gamma_{\omega_{\pm 1}}$ at $w$ is less than $\frac{\pi}{10}$, there exists a Hölder continuous function $f$ on $\overline{\Delta}$, holomorphic on $\Delta$, such that ${\rm Re}(\overline{a(\xi)} f(\xi)) = 0$ on $L$ and $f(\xi)\in\gamma_{\xi}$ on $\partial\Delta\setminus\mathring{L}$. Ključne besede: boundary value problems, mixed Riemann-Hilbert problem, Cherepanov problem Objavljeno v DiRROS: 15.02.2024; Ogledov: 330; Prenosov: 156
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1888. New marker of angiogenesis CD105 (endoglin): diagnostic, prognostic and therapeutic roleMateja Legan, 2005, pregledni znanstveni članek Povzetek: Background. The well established notion that malignant tumours depend on angiogenesis to grow and metastasize focused the investigators interest on tumour vasculature into visualization and validation. Panendothelial markers (CD31, CD34, F8) and CD105 are differentially expressed in angiogenic and normal vessel endothelial cells. Since the former are excellent markers for the normal vasculature, CD105 (endoglin) is more suitable for identifying tumour angiogenesis. Endoglin is a transforming growth factor (TGF)- beta binding receptor, preferentially expressed on endothelial cells of angiogenic tissues, essential for angiogenesis and vascular development. Conclusions. Tumor microvessel density expressed by CD105 immunohistochemical staining in paraffin-embedded tissue section correlates significantly with tumour aggressiveness and prognosis in many solid tumours. Also, targeting of tumour neovasculature specific antigens offers the possibility of future therapeutic approaches. Objavljeno v DiRROS: 14.02.2024; Ogledov: 303; Prenosov: 71
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1889. Small-bowel carcinoid presenting with acute bleeding detected upon wireless capsule endoscopyŽiva Mrevlje, Marko Sever, Borut Kocijančič, 2005, izvirni znanstveni članek Povzetek: Background. Intestine carcinoid usually presents with clinical symptoms and signs deriving from its endocrinological influences and rarely bleeds profusely. Case report. We present a patient with intestinal bleeding of unknown origin. After conventional diagnostic procedures only wireless capsuleendosopy was able to discover a tumour of small bowel, which was the reason of bleeding. On patohistological examination after the surgical resection it proved to be a small bowel carcinoid. Conclusions. There are indications that WCE, besides being the first small bowel imaging technique, is a very important diagnostic tool, deserving consideration in the early phases of diagnosing small-bowel disease, especially in less intensive or occult bleeding. Objavljeno v DiRROS: 14.02.2024; Ogledov: 313; Prenosov: 71
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1890. Quantitative analysis of fine needle aspiration biopsy samplesMirjana Rajer, Marko Kmet, 2005, izvirni znanstveni članek Povzetek: The fine needle aspiration biopsy (FNAB) is one of the methods used in tumour evaluation. Since a certain number of tumour cells are needed for a complete diagnostic algorithem, we wanted to test how many cells remain in the needle and syringe after routine stains have been made and which factors influence this number. The remaining cells are used in ancillary diagnostic procedures. Material and methods. One hundred fifty two FNAB samples of tumours of the breast, thyroid and lymph nodes were included in our study. We counted the cells which were left in the needle and the syringe after the standard smears had been made. Buerker-Tuerks chamber was used for this purpose. Results. The number of cells depended on the organ from which the cells had been aspirated,on the type of tumour and, in the case of breast cancer, also on thelevel of experience of the FNAB performer. The percentage of samples with too few cells for all modern diagnostic methods (<5x105) is lowest in FNAB of lymph nodes (4.9%), followed by breast (16.7%) and thyroid (18%). Conclusions.We concluded that FNAB in the majority of cases grants a sufficient number of cells for the standard microscopic evaluation and also ancillary diagnostic procedures. Objavljeno v DiRROS: 14.02.2024; Ogledov: 308; Prenosov: 60
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