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Povzetek: Background. Trastuzumab therapy given in combination with one of several chemotherapy regimens is currently considered the standard of care for the treatment of early-stage, human epidermal growth factor receptor-2 (HER2) -positive breast cancer. The treatment with trastuzumab is due to a significant impact on the survival part of the standard adjuvant treatment of patients with HER2-positive breast cancer. Patients treated with postoperative breast or chest wall irradiation receive trastuzumab concomitant with radiotherapy. In a small proportion of patients trastuzumab causes cardiotoxicity. Preclinical findings indicate a radiosensibilizing effect of trastuzumab in breast cancer cells, but it is not yet clear whether it radiosensibilizes cells of healthy tissues too.Conclusions. Special attention is required when left breast or left thoracic wall is irradiated in patient receiving trastuzumab, because long-term effects of the concurrent treatment with trastuzumab and radiotherapy are not yet known. In an era where more patients are surviving a diagnosis of breast cancer, better understanding and earlier detection of therapy-induced cardiac toxicity will be of paramount importance.
Ključne besede: radiotherapy, cardiotoxicity, trastuzumab, early breast cancer
Objavljeno v DiRROS: 11.04.2024; Ogledov: 482; Prenosov: 236
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Povzetek: Background. RCC accounts for only 2-3% of all cancers. Due to its non-specific symptoms disease is often diagnosed in advanced stage. Disseminated RCC frequently produces bone metastases that are almost always highly destructive, hyper vascularized and purely osteolytic. Case report. In this article we describe a case of a 71-year old male patient with disseminated osteoblastic bone metastases from renal cell carcinoma (RCC), and present a short review of published literature reporting cases of osteoblastic bone metastases from RCC. Our patient presented with thoracic pain aggravated by movement. He was diagnosed with predominantly osteoblastic bone metastases in the skeleton of thoracic and lumbar vertebra along with metastases in iliac bones, ribs, humerus and clavicles. Initially, origin of bone metastases was unknown, but later a small tumor in patients right kidney was identified. Microscopic evaluation of the open bone biopsy showed clear cell RCC with sarcomatoid differentiation. Conclusions. Although, due to its rarity, RCC is not included in the primary differential diagnosis in patients with osteoblastic metastases, such rare cases suggest that RCC may be considered in the diagnosis when there no other primary tumor is found.
Objavljeno v DiRROS: 11.04.2024; Ogledov: 529; Prenosov: 147
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Povzetek: Background. Intraspinal synovial cysts of vertebral facet joints are uncommon cause of radicular pain as well as neurological deficits. They can be managed both conservatively and surgically.Case report. A 77-year old polymorbid patient presented with bilateral low back pain which worsened during the course of time and did not respond to the conservative treatment. A diagnosis of intraspinal synovial cyst was made using the magnetic resonance imaging (MRI). Percutaneous computed tomography (CT) guided injection with installation of local anesthetic together with corticosteroid and rupture of the cyst was successfully used. A month after the procedure his pain improved, the usage of analgesics diminished and his over-all quality of life improved.Conclusions. Percutaneous CT guided lumbar synovial cyst treatment is safe and reliable alternative to the surgical treatment in polymorbid patients with radiculopathy who are not able to tolerate general anesthesia and operation.
Ključne besede: ciste, intraspinalne sinovialne ciste, bolečina, zdravljenje, radiologija
Objavljeno v DiRROS: 11.04.2024; Ogledov: 417; Prenosov: 240
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Ključne besede: onkologija, rak (medicina), ledvice, karcinom, diagnostika
Objavljeno v DiRROS: 10.04.2024; Ogledov: 413; Prenosov: 137
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Povzetek: We show that if $\Omega$ is an $m$-convex domain in $\mathbb{R}^n$ for some $2 \le m < n$ whose boundary $b\Omega$ has a tubular neighbourhood of positive radius and is not $m$-flat near infinity, then $\Omega$ does not contain any immersed parabolic minimal submanifolds of dimension $\ge m$. In particular, if $M$ is a properly embedded non-flat minimal hypersurface in $\mathbb{R}^n$ with a tubular neighbourhood of positive radius, then every immersed parabolic hypersurface in $\mathbb{R}^n$ intersects $M$. In dimension $n=3$, this holds if $M$ has bounded Gaussian curvature function. We also introduce the class of weakly hyperbolic domains $\Omega$ in $\mathbb{R}^n$, characterised by the property that every conformal harmonic map $\mathbb{C} \to \Omega$ is constant, and we elucidate their relationship with hyperbolic domains, and domains without parabolic minimal surfaces.
Ključne besede: minimal surfaces, m-plurisubharmonic functions, hyperbolic domain
Objavljeno v DiRROS: 10.04.2024; Ogledov: 828; Prenosov: 544
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