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Povzetek: The spread of neophytes (non-native plant species) challenges the conservation status and ecological integrity of forests, especially in lowland areas. Long-term resurvey studies are needed to evaluate the temporal dynamics of neophytes in forests; however, such data are scarce. In 2023, we resampled a set of 45 permanent vegetation plots (established in 1992/93) in two forest vegetation types: oak–hornbeam forests dominated by Quercus robur and colline oak–beech forests dominated by Q. petraea. Over the last 30 years, oak forests have experienced extensive oak tree mortality, with the degree of habitat degradation being greater in Q. robur forests. In the early 1990s, only three neophytes with low abundance were recorded across all plots. In the 2023 resurvey, the total number of neophytes increased to 22 species (15 herbaceous and 7 woody species), comprising 6.9% of the total species pool in the understory layer. The increase in the plot-level number and cover of neophytes was significant in plots dominated by Q. robur but not in those with Q. petraea. The most frequent neophytes were Impatiens parviflora (present in 31% of plots), Solidago gigantea (27%), Erigeron annuus (16%) and Erechtites hieraciifolia (16%). The richness and cover of neophytes were significantly affected by the tree layer cover (negative correlation) and the degree of soil disturbance (positive correlation). All neophytes established in disturbed patches, whereas the occurrence of I. parviflora was exceptional as it was able to colonize less degraded, shaded understory environments. Habitat degradation (the mortality-induced loss of stand-forming oak trees resulting in extensive tree layer cover decrease) emerged as a key driver promoting neophyte proliferation, coupled with the impact of management-induced disturbances affecting overstory and soil conditions. The spread is expected to continue or even intensify in the future because novel light regimes and disturbances make forest habitats less resistant to neophyte proliferation.
Ključne besede: long-term vegetation change, invasive non-native plants, oak mortality, Quercus robur, Quercus petraea, canopy openness, Impatiens parviflora, Slovenia
Objavljeno v DiRROS: 19.04.2024; Ogledov: 432; Prenosov: 274
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Povzetek: High-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements are known for their aggressive clinical course and so are the ones with MYC and BCL2 protein overexpression. The optimal therapy for these lymphomas remains to be elucidated. A retrospective analysis of all diffuse large B-cell lymphomas and high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements diagnosed between 2017 and 2021 at the Institute of Oncology Ljubljana, Slovenia, has been performed. Only patients with double-expressor lymphoma (DEL), double-hit lymphoma (DHL), or triple-hit lymphoma (THL) were included. Demographic and clinical parameters were assessed, as well as progression-free survival (PFS) and overall survival (OS). In total, 161 cases out of 309 (161/309; 52,1%) were classified as DEL. Sixteen patients had DHL, MYC/BCL2 rearrangement was observed in eleven patients, and MYC/BCL6 rearrangement was observed in five patients. Five patients were diagnosed with THL. Out of 154 patients (according to inclusion/exclusion criteria) included in further evaluation, one-hundred and thirty-five patients had double-expressor lymphoma (DEL), sixteen patients had DHL, and three patients had THL. In total, 169 patients were treated with R-CHOP, 10 with R-CHOP and intermediate-dose methotrexate, 19 with R-DA-EPOCH, and 16 with other regimens. The median follow-up was 22 months. The 5-year OS for the whole DEL group was 57.1% (95% CI 45.9–68.3%) and the 5-year PFS was 76.5% (95% CI 72.6–80.4%). The log-rank test disclosed no differences in survival between treatment groups (p = 0.712) while the high-risk international prognostic index (IPI) carried a significantly higher risk of death (HR 7.68, 95% CI 2.32–25.49, p = 0.001). The 5-year OS for DHL patients was 32.4% (95% CI 16.6–48.2%) while all three TH patients were deceased or lost to follow-up. Our analyses of real-life data disclose that the R-CHOP protocol with CNS prophylaxis is a successful and curative treatment for a substantial proportion of DEL patients.
Ključne besede: lymphoma, double-expressor lymphoma, oncology
Objavljeno v DiRROS: 18.04.2024; Ogledov: 441; Prenosov: 232
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Ključne besede: breast cancer, neoadjuvant treatment, surgical treatment
Objavljeno v DiRROS: 18.04.2024; Ogledov: 547; Prenosov: 313
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Povzetek: Fires can lead to costly building damage as well as loss of lives and injuries. Installed to protect buildings from fire, or to limit the damage from such outbreaks, fire protection measures are a common feature in buildings. However, these features come at a cost. Although quite ubiquitous in buildings, the value of these features to private individuals and to society is not fully understood. To understand their value, a cost benefit analysis detailing the costs and benefits of fire protection measures is needed. Carrying out such an analysis requires methods for computing both the cost of these fire protection measures, and losses from fires (including both direct and indirect losses). This study outlines methodologies for evaluating those costs and losses. An exhaustive collection of available data necessary for estimating both costs and losses is presented. Several limitations in current methodologies and data constraints were identified, with recommendations proposed to address these shortcomings. Relevant sections of a study by the authors that refines fire protection cost estimation at national and sub-national levels are emphasized, including updated building categories, guidance on computing multipliers, and detailed cost calculation methods for installation and maintenance costs. The calculation uses regularly updated U.S. Census Bureau construction data, ensuring timely multiplier updates. The insights and suggestions presented in this study will ultimately refine the process of selecting fire protection strategies that maximize the net benefit of fire protection measures for both private stakeholders and society at large.
Ključne besede: fire protection measures, cost of fire protection, losses from fire, cost benefit analysis, installation costs, maintenance costs
Objavljeno v DiRROS: 18.04.2024; Ogledov: 461; Prenosov: 89
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Ključne besede: sports, kinesiology, children, teenagers, research, conferences, reports
Objavljeno v DiRROS: 17.04.2024; Ogledov: 458; Prenosov: 305
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