1. Post-radiation xerostomia therapy with allogeneic mesenchymal stromal stem cells in patients with head and neck cancer : study protocol for phase I clinical trialPrimož Strojan, Gaber Plavc, Marko Kokalj, Goran Mitrović, Olga Blatnik, Luka Ležaič, Aljaž Sočan, Aljoša Bavec, Nataša Tešić, Katrina Pretnar-Hartman, Urban Švajger, 2023, izvirni znanstveni članek Povzetek: Background: Xerostomia is a common side effect of radiotherapy in patients with head and neck tumors that negatively affects quality of life. There is no known effective standard treatment for xerostomia. Here, we present the study protocol used to evaluate the safety and preliminary efficacy of allogeneic mesenchymal stromal stem cells (MSCs) derived from umbilical cord tissue. Methods: Ten oropharyngeal cancer patients with post-radiation xerostomia and no evidence of disease recurrence 2 or more years after (chemo)irradiation (intervention group) and 10 healthy volunteers (control group) will be enrolled in this nonrandomized, open-label, phase I exploratory study. MSCs from umbilical cord tissue will be inserted under ultrasound guidance into both parotid glands and both submandibular glands of the patients. Toxicity of the procedure will be assessed according to CTCAE v5.0 criteria at days 0, 1, 5, 28, and 120. Efficacy will be assessed by measuring salivary flow and analyzing its composition, scintigraphic evaluation of MSC grafting, retention, and migration, and questionnaires measuring subjective xerostomia and quality of life. In addition, the radiological, functional, and morphological characteristics of the salivary tissue will be assessed before, at 4 weeks, and at 4 months after the procedure. In the control group subjects, only salivary flow rate and salivary composition will be determined. Discussion: The use of allogeneic MSCs from umbilical cord tissue represents an innovative approach for the treatment of xerostomia after radiation. Due to the noninvasive collection procedure, flexibility of cryobanking, and biological advantages, xerostomia therapy using allogeneic MSCs from umbilical cord tissue may have an advantage over other similar therapies.
Ključne besede: oropharyngeal cancer, xerostomia, mesenchymal stromal stem cells
Objavljeno v DiRROS: 26.07.2024; Ogledov: 389; Prenosov: 180
 Celotno besedilo (1,91 MB)
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2. MRI značilnosti stranskih učinkov radioterapije centralnega živčevjaGoran Mitrović, 2022, objavljeni znanstveni prispevek na konferenci Povzetek: V sklopu radiološke obravnave bolnikov z možganskim tumorjem je temeljna slikovna preiskava
magnetno resonančno slikanje (MR) glave. Na Onkološkem Inštitutu v Ljubljani je večina preiskav pri
bolnikih z možganskimi tumorji opravljena v fazi sledenja, torej po predhodnem operativnem posegu in radioterapiji. Radioterapija ostaja standardna modaliteta zdravljenja možganskih tumorjev. Kljub razvoju radioterapevstskih tehnik v zadnjih desetletjih se po obsevanju pogosto srečujemo s stranskimi učinki. Z radiološkega vidika sta posebej zanimiva psevdoprogres in radiacijska nekroza, ki se jih na klasičnih MR sekvencah ne da ločiti od recidiva oz. progresa osnovne bolezni. Uporaba dopolnilnih MR tehnik, kot so difuzijsko slikanje, MR perfuzija ter MR spektroskopija, glede na opravljene študije bistveno poveča specifičnost in senzitivnost.
Ključne besede: možganski tumorji, centralno živčevje, radioterapija
Objavljeno v DiRROS: 15.12.2022; Ogledov: 560; Prenosov: 138
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