991. Adaptive visual quality inspection based on defect prediction from production parametersZvezdan Lončarević, Simon Reberšek, Samo Šela, Jure Skvarč, Aleš Ude, Andrej Gams, 2024, izvirni znanstveni članek Povzetek: At the end of a production process, the manufactured products must usually be visually inspected to ensure their quality. Often, it is necessary to inspect the final product from several viewpoints. However, the inspection of all possible aspects might take too long and thus create a bottleneck in the production process. In this paper we propose and evaluate a methodology for adaptive, robot-aided visual quality inspection. With the proposed method, the most probable defects are first predicted based on the production process parameters. A suitable classifier for defect prediction is learnt in an unsupervised manner from a database that includes the produced parts and the associated parameters.Arobot then steers the camera only towards viewpoints associated with predicted defects, which implies that the trajectories of robot motion for the inspection might be different for every product. To enable dynamic planning of camera trajectories, we describe a methodology for evaluation and selection of the most appropriate autonomous motion planner. The proposed defect prediction approach was compared to other methods and evaluated on the products from a real-world production line for injection moulding, which was implemented for a producer of parts in the automotive industry. Ključne besede: robot learning, robotic quality inspection, visual quality inspection, injection moulding, production parameters, robot motion planning Objavljeno v DiRROS: 15.07.2024; Ogledov: 207; Prenosov: 172
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992. Embedded complex curves in the affine planeAntonio Alarcón, Franc Forstnerič, 2024, izvirni znanstveni članek Povzetek: This paper brings several contributions to the classical Forster-Bell-Narasimhan conjecture and the Yang problem concerning the existence of proper and almost proper (hence complete) injective holomorphic immersions of open Riemann surfaces in the affine plane ${\mathbb C}^2$ satisfying interpolation and hitting conditions. We also show that in every compact Riemann surface there is a Cantor set whose complement admits a proper holomorphic embedding in ${\mathbb C}^2$. The focal point is a lemma saying the following. Given a compact bordered Riemann surface, $M$, a closed discrete subset $E$ of its interior ${\mathring M}=M\setminus bM$, a compact subset $K\subset {\mathring M}\setminus E$ without holes in $\mathring M$, and a ${\cal C}^1$ embedding $f: M\hookrightarrow \mathbb C^2$ which is holomorphic in $\mathring M$, we can approximate $f$ uniformly on $K$ by a holomorphic embedding $F: bM\hookrightarrow {\mathbb C}^2$ which maps $E\cup bM$ out of a given ball and satisfies some interpolation conditions. Ključne besede: Riemann surfaces, complex curves, complete holomorphic embedding Objavljeno v DiRROS: 15.07.2024; Ogledov: 201; Prenosov: 119
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993. Transarterial embolization of the external carotid artery in the treatment of life-threatening haemorrhage following blunt maxillofacial traumaČrt Langel, Dimitrij Lovrič, Urša Boneš, Tomislav Mirković, Primož Gradišek, Anita Mrvar Brečko, Katarina Šurlan Popović, 2020, pregledni znanstveni članek Povzetek: Background. Severe bleeding after blunt maxillofacial trauma is a rare but life-threatening event. Non-responders to conventional treatment options with surgically inaccessible bleeding points can be treated by transarterial embolization (TAE) of the external carotid artery (ECA) or its branches. Case series on such embolizations are small; considering the relatively high incidence of maxillofacial trauma, the ECA TAE procedure has been hypothesized either underused or underreported. In addition, the literature on the ECA TAE using novel non-adhesive liquid embolization agents is remarkably scarce.Patients and methods. PubMed review was performed to identify the ECA TAE literature in the context of blunt maxillofacial trauma. If available, the location of the ECA injury, the location of embolization, the chosen embolization agent, and efficacy and safety of the TAE were noted for each case. Survival prognostic factors were also reviewed. Additionally, we present an illustrative TAE case using a precipitating hydrophobic injectable liquid (PHIL) to safely and effectively control a massive bleeding originating bilaterally in the ECA territories.Results and conclusions. Based on a review of 205 cases, the efficacy of TAE was 79.4-100%, while the rate of major complications was about 2-4%. Successful TAE haemostasis, Glasgow Coma Scale score >- 8 at presentation, injury severity score <- 32, shock index <- 1.1 before TAE and <- 0.8 after TAE were significantly correlated with higher survival rate. PHIL allowed for fast yet punctilious application, thus saving invaluable time in life-threatening situations while simultaneously diminishing the possibility of inadvertent injection into the ECA-internal carotid artery (ICA) anastomoses. Ključne besede: maxillofacial trauma, external carotid artery injury, intractable bleeding Objavljeno v DiRROS: 12.07.2024; Ogledov: 214; Prenosov: 121
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994. Impact of COVID-19 on cancer diagnosis and management in Slovenia : preliminary resultsVesna Zadnik, Ana Mihor, Sonja Tomšič, Tina Žagar, Nika Bric, Katarina Lokar, Irena Oblak, 2020, izvirni znanstveni članek Ključne besede: covid-19, oncology, oncology diagnosis, pandemic Objavljeno v DiRROS: 12.07.2024; Ogledov: 223; Prenosov: 101
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995. Care of patients with non-small-cell lung cancer stage III : the Central European real-world experienceMilada Zemanova, Robert Pirker, Luboš Petruželka, Zuzana Zbozínkova, Mirjana Rajer, Krisztina Bogos, Gunta Purkalne, Vesna Ceriman, Subhash Chaudhary, Igor Richter, 2020, izvirni znanstveni članek Povzetek: Background. Management of non-small-cell lung cancer (NSCLC) is affected by regional specificities. The present study aimed at determining diagnostic and therapeutic procedures including outcome of patients with NSCLC stage III in the realworld setting in Central European countries to define areas for improvements. Patients and methods. This multicentre, prospective and non-interventional study collected data of patients with NSCLC stage III in a web-based registry and analysed them centrally. Results. Between March 2014 and March 2017, patients (n=583) with the following characteristics were entered: 32% females, 7% never-smokers; ECOG performance status (PS) 0, 1, 2 and 3 in 25%, 58%, 12% and 5%, respectively; 21% prior weight loss; 53% squamous carcinoma, 38% adenocarcinoma; 10% EGFR mutations. Staging procedures included chest X-ray (97% of patients), chest CT (96%), PET-CT (27%), brain imaging (20%), bronchoscopy (89%), endobronchial ultrasound (EBUS) (13%) and CT-guided biopsy (9%). Stages IIIA/IIIB were diagnosed in 55%/45% of patients, respectively. N2/N3 nodes were diagnosed in 60%/23% and pathologically confirmed in 29% of patients. Most patients (56%) were treated by combined modalities. Surgery plus chemotherapy was administered to 20%, definitive chemoradiotherapy to 34%, chemotherapy only to 26%, radiotherapy only to 12% and best supportive care (BSC) to 5% of patients. Median survival and progression-free survival times were 16.8 (15.3;18.5) and 11.2 (10.2;12.2) months, respectively. Stage IIIA, female gender, no weight loss, pathological mediastinal lymph node verification, surgery and combined modality therapy were associated with longer survival. Conclusions. The real-world study demonstrated a broad heterogeneity in the management o f stage III NSCLC in Central European countries and suggested to increase the rates of PET-CT imaging, brain imaging and invasive mediastinal staging. Ključne besede: diagnostic procedures, multimodality treatment, non-small-cell cancer, lung cancer Objavljeno v DiRROS: 12.07.2024; Ogledov: 199; Prenosov: 122
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997. Percutaneous image guided electrochemotherapy of hepatocellular carcinoma : technological advancementMihajlo Djokić, Rok Dežman, Maja Čemažar, Miha Štabuc, Miha Petrič, Lojze Šmid, Rado Janša, Boštjan Plešnik, Maša Omerzel, Urša Lampreht Tratar, Blaž Trotovšek, Bor Kos, Damijan Miklavčič, Gregor Serša, Peter Popović, 2020, izvirni znanstveni članek Povzetek: Background. Electrochemotherapy is an effective treatment of colorectal liver metastases and hepatocellular carcinoma (HCC) during open surgery. The minimally invasive percutaneous approach of electrochemotherapy has already been performed but not on HCC. The aim of this study was to demonstrate the feasibility, safety and effectiveness of electrochemotherapy with percutaneous approach on HCC. Patient and methods. The patient had undergone the transarterial chemoembolization and microwave ablation of multifocal HCC in segments III, V and VI. In follow-up a new lesion was identified in segment III, and recognized by multidisciplinary team to be suitable for minimally invasive percutaneous electrochemotherapy. The treatment was performed with long needle electrodes inserted by the aid of image guidance. Results. The insertion of electrodes was feasible, and the treatment proved safe and effective, as demonstrated by control magnetic resonance imaging. Conclusions. Minimally invasive, image guided percutaneous electrochemotherapy is feasible, safe and effective in treatment of HCC. Ključne besede: electrochemotherapy, hepatocellular carcinoma, percutaneous, minimally invasive Objavljeno v DiRROS: 12.07.2024; Ogledov: 221; Prenosov: 118
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998. Sorafenib for the treatment of hepatocellular carcinoma : a single-centre real-world studyJurij Hanžel, Tajda Božič, Borut Štabuc, Rado Janša, 2020, izvirni znanstveni članek Povzetek: Background Sorafenib is an oral multi-kinase inhibitor used for the treatment of hepatocellular carcinoma. Its efficacy in randomised controlled trials was demonstrated in patients with well-preserved liver function and good functional status. In the real-world setting, treatment is often offered to patients outside these criteria. We therefore performed a single-centre real-world cohort study on the efficacy of sorafenib in patients with hepatocellular carcinoma. Patients and methods We identified all patients with hepatocellular carcinoma initiating treatment with sorafenib between January 2015 and January 2018. The primary endpoint was overall survival (OS) since starting sorafenib. Clinical and demographic variables associated with survival were studied. Results The median OS was 13.4 months (95% CI 8.2%18.6). Multivariable Cox%s regression identified worse ECOG performance status (HR 2.21; 95% CI 1.56%3.16; P < 0.0001), Child-Pugh class C (HR 52.4; 95% CI 3.20%859; P = 0.005) and absence of prior locoregional treatment (HR 2.30; 95% CI 1.37%3.86; P = 0.002) to be associated with increased mortality. Conclusions Careful selection of patients for treatment with sorafenib is of paramount importance to optimize outcomes. Ključne besede: hepatocellular carcinoma, survival, sorafenib Objavljeno v DiRROS: 12.07.2024; Ogledov: 193; Prenosov: 120
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999. Diagnostic accuracy of (1-3)-[beta]-D-glucan to predict Pneumocystis jirovecii pneumonia in non-HIV-infected patientsPetra Rogina, Miha Skvarč, 2020, izvirni znanstveni članek Povzetek: Background Pneumocystis jirovecii pneumonia (PCP) is a common and potentially fatal opportunistic infection in immunocompromised non-HIV individuals. There are problems with clinical and diagnostic protocols for PCP that lack sensitivity and specificity. We designed a retrospective study to compared several methods that were used in diagnostics of PCP. Patients and methods One hundred and eight immunocompromised individuals with typical clinical picture for PCP and suspicious radiological findings were included in the study. Serum samples were taken to measure the values of (1-3)-[beta]-D-glucan (Fungitell, Associates of Cape Cod, USA). Lower respiratory tract samples were obtained to perform direct immunofluorescence (DIF, MERIFLUOR Pneumocystis, Meridian, USA) stain and real-time PCR (qPCR). Results Fifty-four (50%) of the 108 patients in our study had (1-3)-[beta]-D-glucan > 500 pg/ml. Patients that had (1-3)-[beta]-D-glucan concentrations < 400 pg/ml in serum, had mean threshold cycles (Ct) 35.43 +- 3.32 versus those that had (1-3)-[beta]-D-glucan concentrations >400 pg/mL and mean Ct of 28.97 +- 5.27 (P < 0.001). If we detected P. jirovecii with DIF and qPCR than PCP was proven. If the concentration of (1-3)-[beta]-D-glucan was higher than 400 pg/ml and Ct of qPCR was below 28.97 +- 5.27 than we have been able be certain that P. jirovecii caused pneumonia (odds ratio [OR] 2.31, 95% confidence interval [CI] 1.62-3.27, P < 0.001). Conclusions Measurement of (1-3)-[beta]-D-glucan or qPCR alone could not be used to diagnose PCP. Diagnostic cut-off value for (1-3)-[beta]-D-glucan > 400pg/ml and qPCR below 30 Ct, allow us to conclude that patient has PCP. If the values of (1-3)-[beta]-D-glucan are < 400 pg/ml and qPCR is above 35 Ct than colonization with P. jirovecii is more possible than PCP. Ključne besede: Pneumocystis jirovecii pneumonia, real-time PCR, non-HIV-infected patients Objavljeno v DiRROS: 12.07.2024; Ogledov: 179; Prenosov: 140
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1000. Mechanical recanalization for acute bilateral cerebral artery occlusion - literature overview with a caseMiran Jeromel, Zoran Miloševič, Janja Pretnar-Oblak, 2020, pregledni znanstveni članek Povzetek: Background. Acute bilateral internal carotid artery (ICA) and/or middle cerebral artery (MCA) occlusion is extremely rare and associated with poor clinical outcomes. There are only a few reports in the literature about mechanical thrombectomy being performed for acute bilateral occlusions. The treatment strategies and prognoses (clinical outcomes) are therefore unclear. Methods. A systematic review of the literature was performed through several electronic databases with the following search terms: acute bilateral stroke, mechanical recanalization and thrombectomy. Results. In the literature, we identified five reports of six patients with bilateral ICA and/or MCA occlusion treated with mechanical recanalization. Additionally, we report our experience with a subsequent contralateral large brain artery occlusion during intravenous thrombolytic therapy, where the outcome after mechanical thrombectomy was not dependent on the time from stroke onset but rather on the capacity of collateral circulation exclusively. Conclusions. Acute bilateral cerebral (ICA and/or MCA) occlusion leads to sudden severe neurological deficits (comas) with unpredicted prognoses, even when mechanical recanalization is available. As the collateral capacity seems to be more important than the absolute time to flow restoration in determining the outcomes, simultaneous thrombectomy by itself probably does not lead to improved functional outcomes. Ključne besede: acute bilateral stroke, mechanical recanalization, thrombectomy Objavljeno v DiRROS: 12.07.2024; Ogledov: 226; Prenosov: 119
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