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323. Poročilo o preskusu št.: LVG 2022-121 : vzorec št. 2022/00500/V1Nikica Ogris, Andreja Kavčič, Zina Devetak, Maša Zagorac, Barbara Piškur, 2022, izvedensko mnenje, arbitražna odločba Ključne besede: varstvo gozdov, morfološke analize, Geosmithia morbida, bolezen tisočerih rakov, Zeuzera pyrina, modro sitce
Objavljeno v DiRROS: 21.09.2022; Ogledov: 441; Prenosov: 0 |
324. Poročilo o preskusu št.: LVG 2022-120 : vzorec št. 2022/00403Barbara Piškur, Špela Jagodic, Maša Zagorac, Nikica Ogris, 2022, izvedensko mnenje, arbitražna odločba Ključne besede: varstvo gozdov, morfološke analize, veliki pajesen, Ailanthus altissima, nekroza, izcedek, smola
Objavljeno v DiRROS: 21.09.2022; Ogledov: 475; Prenosov: 0 |
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326. BAP1-defficient breast cancer in a patient with BAP1 cancer syndromeAna Blatnik, Domen Ribnikar, Vita Šetrajčič Dragoš, Srdjan Novaković, Vida Stegel, Biljana Grčar-Kuzmanov, Nina Boc, Barbara Perić, Petra Škerl, Gašper Klančar, Mateja Krajc, 2022, izvirni znanstveni članek Povzetek: BAP1 cancer syndrome is a rare and highly penetrant hereditary cancer predisposition. Uveal melanoma, mesothelioma, renal cell carcinoma (RCC) and cutaneous melanoma are considered BAP1 cancer syndrome core cancers, whereas association with breast cancer has previously been suggested but not confirmed so far. In view of BAP1 immunomodulatory functions, BAP1 alterations could prove useful as possible biomarkers of response to immunotherapy in patients with BAP1-associated cancers. We present a case of a patient with BAP1 cancer syndrome who developed a metastatic breast cancer with loss of BAP1 demonstrated on immunohistochemistry. She carried a germline BAP1 likely pathogenic variant (c.898_899delAG p.(Arg300Glyfs*6)). In addition, tumor tissue sequencing identified a concurrent somatic variant in BAP1 (partial deletion of exon 12) and a low tumor mutational burden. As her triple negative tumor was shown to be PD-L1 positive, the patient was treated with combination of atezolizumab and nab-paclitaxel. She had a complete and sustained response to immunotherapy even after discontinuation of nab-paclitaxel. This case strengthens the evidence for including breast cancer in the BAP1 cancer syndrome tumor spectrum with implications for future cancer prevention programs. It also indicates immune checkpoint inhibitors might prove to be an effective treatment for BAP1-deficient breast cancer.
Ključne besede: BAP1, breast cancer, hereditary cancer syndromes, immunotherapy
Objavljeno v DiRROS: 19.09.2022; Ogledov: 505; Prenosov: 198
 Celotno besedilo (1,12 MB) |
327. First report of Diplodia fraxini and Diplodia subglobosa causing canker and dieback of Fraxinus excelsior in SloveniaBenedetto Teodoro Linaldeddu, Carlo Bregant, Lucio Montecchio, Ana Brglez, Barbara Piškur, Nikica Ogris, 2022, drugi znanstveni članki Povzetek: Over the last decades the vitality and productivity of European ash trees in Slovenia has been seriously impacted by the onset of canker and dieback disease symptoms on young and old trees, primarily identified as ash dieback caused by Hymenoscyphus fraxineus. Given the limited information available about the aetiology of this emerging disease, a study was carried out to isolate, identify and characterize the fungal species involved in the observed ash symptoms. Field surveys were conducted in five forest sites where 50 symptomatic branch samples were collected. All samples were inspected and used for fungal isolation. Based on morphology, colony appearance and DNA sequence data of the internal transcribed spacer region (ITS), 125 fungal colonies belonging to five species were isolated and identified. Only a few symptomatic ash samples yielded colonies of H. fraxineus, whereas Botryosphaeriaceae species were isolated with a high frequency, with Diplodia fraxini as the dominant species. A pathogenicity test proved that all isolated species were pathogenic on European ash, causing bark lesions and wood discoloration. All Botryosphaeriaceae species isolated in this study are reported for the first time on European ash in Slovenia.
Ključne besede: emerging disease, invasive species, Botryosphaeriaceae, pathogenicity
Objavljeno v DiRROS: 15.09.2022; Ogledov: 496; Prenosov: 210
Celotno besedilo (851,52 KB)
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330. Analysis of putative apoplastic effectors from the nematode, Globodera rostochiensis, and identification of an expansin-like protein that can induce and suppress host defensesBarbara Gerič Stare, Shawkat Ali, Maxime Magne, Shiyan Chen, Olivier Côte, Natasa Obradovic, Lubna Jamshaid, Xiaohong Wang, Guy Bélair, Peter Moffett, 2015, izvirni znanstveni članek Ključne besede: nematode, expansin-like protein, expansin, potato cyst nematode, potato pest, parasitic nematodes, plant celular function
Objavljeno v DiRROS: 06.09.2022; Ogledov: 518; Prenosov: 220
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