11. Hymenoptera venom immunotherapy : immune mechanisms of induced protection and toleranceAjda Demšar, Peter Korošec, Mitja Košnik, Mihaela Zidarn, Matija Rijavec, 2021, pregledni znanstveni članek Povzetek: Hymenoptera venom allergy is one of the most severe allergic diseases, with a considerable prevalence of anaphylactic reaction, making it potentially lethal. In this review, we provide an overview of the current knowledge and recent findings in understanding induced immune mechanisms during different phases of venom immunotherapy. We focus on protection mechanisms that occur early, during the build-up phase, and on the immune tolerance, which occurs later, during and after Hymenoptera venom immunotherapy. The short-term protection seems to be established by the early desensitization of mast cells and basophils, which plays a crucial role in preventing anaphylaxis during the build-up phase of treatment. The early generation of blocking IgG antibodies seems to be one of the main reasons for the lower activation of effector cells. Long-term tolerance is reached after at least three years of venom immunotherapy. A decrease in basophil responsiveness correlates with tolerated sting challenge. Furthermore, the persistent decline in IgE levels and, by monitoring the cytokine profiles, a shift from a Th2 to Th1 immune response, can be observed. In addition, the generation of regulatory T and B cells has proven to be essential for inducing allergen tolerance. Most studies on the mechanisms and effectiveness data have been obtained during venom immunotherapy (VIT). Despite the high success rate of VIT, allergen tolerance may not persist for a prolonged time. There is not much known about immune mechanisms that assure longterm tolerance post-therapy.
Ključne besede: allergy and immunology, hypersensitivity, immunotherapy, immune tolerance, venoms, Hymenoptera, Hymenoptera venom, short-term protection, long-term tolerance
Objavljeno v DiRROS: 16.08.2021; Ogledov: 943; Prenosov: 295
 Povezava na datoteko |
12. Five nuclear protein-coding markers for establishing a robust phylogenetic framework of niphargid crustaceans (Niphargidae: Amphipoda) and new molecular sequence dataAjda Moškrič, Rudi Verovnik, 2019, izvirni znanstveni članek Ključne besede: phylogenetic analyses, nucleotide sequences, protein-coding, PCR, molecular evolution, nuclear protein-coding loci, opsin, arginine kinase, phosphoenolpyruvate carboxykinase, glyceraldehyde phosphate dehydrogenase
Objavljeno v DiRROS: 16.04.2020; Ogledov: 1921; Prenosov: 498
 Datoteka (862,07 KB) |
13. Ali imamo v Sloveniji na voljo naravno odporen les?Ajda Pogorelčnik, Nejc Thaler, Boštjan Lesar, Davor Kržišnik, Miha Humar, 2017, strokovni članek Povzetek: V zadnjem obdobju se raba lesa veča, še posebno za gradbene namene. Na prostem je les izpostavljen delovanju biotskih in abiotskih dejavnikov razkroja. Teh procesov ne moremo preprečiti, s pravilnim načrtovanjem konstrukcij, izbiro ustreznih lesnih vrst ali biocidno zaščito pa jih lahko zelo omejimo. Pri izbiri lesa je eden od najpomembnejših podatkov njegova naravna odpornost. Letos je bil objavljen nov standard, ki na tem področju prinaša številne novosti. Najbolj izrazito je zmanjšanje odpornosti macesnovine in hrastovine, predvsem zaradi variabilnosti lesa, ki je v celoti ne znamo pojasniti. V tem prispevku so navedena najnovejša spoznanja in nekateri rezultati, ki se nanašajo na naravno odpornost in življenjsko dobo lesa.
Ključne besede: les, naravna odpornost, življenjska doba, razkroj lesa, glive
Objavljeno v DiRROS: 03.09.2017; Ogledov: 3444; Prenosov: 741
Celotno besedilo (139,49 KB) |
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