141. Odpornost glioblastoma na radioterapijo : vpliv rakavih matičnih celic in mikroo[ko]lja tumorjaBarbara Breznik, Bernarda Majc, Anamarija Habič, Urška Ušeničnik, Andrej Porčnik, Roman Bošnjak, Jernej Mlakar, Marija Skoblar Vidmar, Tanja Jesenko, Maja Čemažar, Tamara Lah Turnšek, Metka Novak, 2022, objavljeni znanstveni prispevek na konferenci (vabljeno predavanje) Povzetek: Glioblastom je najpogostejši možganski tumor pri odraslih z zelo slabo prognozo preživetja bolnikov. Ta je posledica odpornosti glioblastoma na standardno zdravljenje, ki vključuje radioterapijo in kemoterapijo. Z namenom načrtovanja učinkovitejših pristopov zdravljenja preučujemo biološke mehanizme odpornosti glioblastoma na radioterapijo s poudarkom na mikrookolju tumorja in rakavih matičnih celicah. V predkliničnih raziskavah uporabljamo napredne in personalizirane celične modele, ki posnemajo mikrookolje tumorja v bolnikih in z večjo natančnostjo napovedo odziv bolnika na zdravljenje. Hkrati so takšni modeli pomembni za testiranje novih pristopov za zdravljenje kot je imunoterapija.
Ključne besede: glioblastom, mikrookolje, organoidi, možganski rak, možganski tumor, onkologija
Objavljeno v DiRROS: 16.06.2022; Ogledov: 643; Prenosov: 203
 Celotno besedilo (89,78 KB) |
142. Nacionalna gozdna inventura : interna navodila za terensko delo (2020-2024) : (ver. 02 / 2022) : dopolnitve 13. 5. 2022Mitja Skudnik, Jure Žlogar, Aleš Poljanec, Rok Pisek, Anže Martin Pintar, Gal Kušar, Matjaž Guček, Andrej Grah, Marko Kovač, 2020, slovar, enciklopedija, leksikon, priročnik, atlas, zemljevid Ključne besede: nacionalna gozdna inventura, monitoring, terenske meritve, trajne vzorčne ploskve, navodila
Objavljeno v DiRROS: 07.06.2022; Ogledov: 930; Prenosov: 364
Celotno besedilo (4,71 MB) |
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144. Določitev ploskev tretjega panela Nacionalne gozdne inventure za terenski popis gozd/druga gozdna zemljišča/negozd : predstavljeno na spletnem seminarju in delavnici Nacionalna Gozdna Inventura 2022 in Sklad za podnebne spremembe, 11. - 15. 4. 2022Anže Martin Pintar, Andrej Grah, Mitja Skudnik, 2022, prispevek na konferenci brez natisa Ključne besede: gozdovi, gozdarstvo, raba zemljišč, Nacionalna gozdna inventura, definicija gozda, negozd, druge gozdne površine
Objavljeno v DiRROS: 12.04.2022; Ogledov: 808; Prenosov: 0 |
145. Minimalno invazivni diagnostični pristopi pri primarnih možganskih tumorjih z uporabo prosto cirkulirajočih nukleinskih kislinMarija Skoblar Vidmar, Jernej Mlakar, Uroš Smrdel, Alenka Matjašič, Jože Pižem, Andrej Zupan, 2021, objavljeni znanstveni prispevek na konferenci Ključne besede: tekočinska biopsija, onkološko zdravljenje, možganski tumorji
Objavljeno v DiRROS: 04.04.2022; Ogledov: 638; Prenosov: 237
Celotno besedilo (123,97 KB) |
146. Chemical and isotopic composition of CO2-rich magnesium- sodium-bicarbonate-sulphate-type mineral waters from volcanoclastic aquifer in Rogaška Slatina, SloveniaNina Rman, László Palcsu, Andrej Lapanje, Teodóra Szőcs, 2022, izvirni znanstveni članek Povzetek: Bottled natural mineral waters from an andesitic aquifer in Slovenia are enriched in magnesium (1.1 g/l), sulphate (2.2 g/l) and dissolved inorganic carbon (204 g/l). We analysed major ions, trace elements, tritium activity, 14 C, d18 OH2O , d2 HH2O, d13 CDIC, gas composition and noble gases in six wells. In addition, 87 Sr/ /86 Sr, d34 SSO4 and d11 B were analysed here for the first time. Stable isotopes with d18 O = -11.97 to -10.30% and d2 H = -77.3 to -63.8 confirm meteoric origin. CO2 degassing is evident at three wells, causing the oxygen shift of about -1.3%. Tritium activity was detectable only in the shallowest well, where the freshwater component was dated to the 1960s. d13 CDIC in five waters is -1.78 to ? 1.33%, typical of carbonate dissolution. Radiocarbon is low, 1.03–5.16 pMC. Chemical correction with bicarbonate concentration and d13 C correction methods gave best mean residence times, slightly longer than previously published. Sulphate has d34 S 26.6–28.9% and d18 O 8.9–11.1% due to dissolution of evaporites in carbonate rocks. Boron at concentrations of 1.2–6.1 mg/l has two origins: d11 B = 11.3–16.4% from hydrothermal alteration and d11 B = 26.6–31.7% from carbonate dissolution. Strontium at concentrations of 0.5–22.0 mg/l has 87 Sr/ /86 Sr, indicating three sources: 0.7106 for Miocene clastic rocks, 0.7082 for Triassic carbonates and 0.7070 for Lower Oligocene andesitic rocks. CO 2 represents the majority of the dissolved ([ 98.84 vol%) and separated gas ([ 95.23 vol%). Methane is only found in two wells with a max. of 0.30 vol%. All waters show excess helium and 16–97% of mantlederived helium. Since all show subsurface degassing, the paleo-infiltration temperature could not be calculated.
Ključne besede: natural tracers, carbon, sulphur, strontium and boron isotopes, noble gases
Objavljeno v DiRROS: 24.03.2022; Ogledov: 807; Prenosov: 270
Celotno besedilo (3,11 MB) |
147. Catalytic hydrocracking reactions of tetralin biomass tar model compound to benzene, toluene and xylenes (BTX) over metal-modified ZSM-5 in ambient pressure reactorAndrii Kostyniuk, David Bajec, Blaž Likozar, 2022, izvirni znanstveni članek Ključne besede: catalytic hydrocracking reactions, ring opening mechanism, model biomass tar, benzene/toluene/xylenes (BTX), metal-doped HZSM-5 zeolite material, deposited coke deactivation
Objavljeno v DiRROS: 10.03.2022; Ogledov: 703; Prenosov: 544
Celotno besedilo (5,34 MB)
Gradivo ima več datotek! Več... |
148. Geophysical investigations in the Radovna River Spring area (Julian Alps, NW Slovenia)Anja Torkar, Marjana Zajc, Jure Atanackov, Andrej Gosar, Mihael Brenčič, 2021, izvirni znanstveni članek Povzetek: The Radovna River Valley is located in the north-western part of Slovenia in the Julian Alps, where there is an extensive intergranular aquifer whose depth to pre-Quaternary bedrock is unknown. Therefore, to obtain information about the depth of the valley and the geometry of the aquif er two geophysical methods were used in our study; ground penetrating radar (GPR) and seismic reflection method. The low-frequency GPR method has shown to be useful for determining the depth of the groundwater and the predominant groundwater recharge. Also, the high-resolution seismic method provided an insight about the morphology of the pre-Quaternary basement with the deepest point at 141 meters below surface. Measurements of hydrogeological parameters such as groundwater level and river discharge measurements were carried out in the study area. Both data analyses showed that groundwater level and river discharge are highly fluctuatingand rapidly changing, indicating a well-permeable aquifer, implying that such an aquifer is extremely sensitive and vulnerable to extreme climate events. Both the geophysical methods and the hydrogeological information have provided important information about the morphology of the valley and the alluvial aquifer, as well as increasing the knowledge about the Radovna springs system, which will contribute very important information for future hydrogeological studies.
Ključne besede: Ground penetrating radar, Seismic reflection method, Radovna spring, hydrogeology, aquifer geometry, glacial valley, groundwater table
Objavljeno v DiRROS: 09.03.2022; Ogledov: 767; Prenosov: 326
Celotno besedilo (6,27 MB) |
149. Sistem opredelitve rabe tal na ploskvah nacionalne gozdne inventure 2022 (gozd/drugo gozdno zemljišče/negozd) : seminar : online seminar v organizaciji Oddelka za načrtovanje in monitoring gozdov in krajine, Gozdarski inštitut Slovenije, Ljubljana, 31. 1. in 1. 2. 2022, onlineAnže Martin Pintar, Andrej Grah, Mitja Skudnik, 2022, druga izvedena dela Ključne besede: gozdarstvo, gozdovi, negozd, definicija gozda, druge gozdne površine, nacionalna gozdna inventura, gozdna inventura, fotointerpretacija, gozdni rob, raba tal, terenski popis
Objavljeno v DiRROS: 24.02.2022; Ogledov: 946; Prenosov: 0 |
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