71. A preliminary overview of raptor monitoring in Slovenia : an overview of methodologies, current monitoring status and future perspectivesAl Vrezec, 2012, pregledni znanstveni članek Povzetek: Among 48 raptor species (birds of prey, owls, shrikes) recorded recently in Slovenia, some long-term monitoring activities are being conducted for more than half of them, mainly for conservation and research purposes. However, national coverage is achieved only in 15% of the species, whereas other monitoring programmes are more or less local. Two monitoring approaches are considered, the species specific approach and assemblage approach. Current ongoing monitoring programmes for raptors in Slovenia lack monitoring of breeding success, which is now confined to only a few owl species. Use of nestboxes should therefore be considered more broadly in the future for some species at least. Ključne besede: Slovenia, raptor monitoring, birds of prey, owls, shrikes, monitoring methodology Objavljeno v DiRROS: 06.08.2024; Ogledov: 121; Prenosov: 68
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72. Overview of raptor monitoring activities in EuropeAl Vrezec, Guy Duke, András Kovács, Pertti Saurola, Chris Wernham, Ian Burfield, Paola Movalli, Irena Bertoncelj, 2012, pregledni znanstveni članek Povzetek: Despite the key role of raptors (including birds of prey Falconiformes and owls Strigiformes) in ecosystems and their sensitivity to environmental change, a well coordinated, Europe-wide monitoring of raptors is lacking. EURAPMON, a Research Networking Programme of the European Science Foundation, was launched with the aim of establishing a sustainable Europewide network for monitoring of raptors. An overview of current monitoring schemes for raptor populations in 28 European countries, as reported by EURAPMON National Coordinators at the workshop in Murcia (Spain) in 2012, showed existing monitoring schemes to be limited to a restricted number of species (mostly diurnal and rare raptor species). The most widely monitored species are the Golden Eagle Aquila chrysaetos amongst diurnal raptors and the Eagle Owl Bubo bubo amongst owls. Broad coverage of a species range across Europe is reached only for restricted-range species. The key driver for monitoring, which is mostly coordinated by NGOs, is conservation, and the main end users are governmental institutions. International collaboration in the field of monitoring of raptors is mainly regional and not yet pan-European in scale. The involvement of volunteers in raptor monitoring was perceived as the main strength of many schemes, but insufficient manpower and a focus on rare species were recognised as the main weaknesses across Europe as a whole. Among priorities identified for the future development of monitoring schemes are: improvements to national coordination; support to increase the number of volunteers; and assurances of stable funding. Further analysis of EURAPMON questionnaires will identify knowledge gaps, which will steer good practice guidance on survey methodologies; the need for the latter was identified as the main benefit that National Coordinators expect to gain from international networking Ključne besede: Europe, raptor monitoring scheme, birds of prey, owls, monitoring inventory Objavljeno v DiRROS: 06.08.2024; Ogledov: 116; Prenosov: 81
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73. Nanoparticles for hyperthermic therapy : synthesis strategies and applications in glioblastomaJyoti Verma, Sumit Lal, Cornelis J. F. van Noorden, 2014, pregledni znanstveni članek Povzetek: Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans. Current GBM treatment includes surgery, radiation therapy, and chemotherapy, sometimes supplemented with novel therapies. Despite recent advances, survival of GBM patients remains poor. Major challenges in GBM treatment are drug delivery across the blood–brain barrier, restriction of damage to healthy brain tissues, and limitation of resistance to therapies. This article reviews recent advances in the application of magnetic nanoparticles (MNPs), gold nanorods (GNRs), and carbon nanotubes (CNTs) for hyperthermia ablation of GBM. First, the article introduces GBM, its current treatment, and hyperthermia as a potential modality for the management of GBM. Second, it introduces MNPs, GNRs, and CNTs as inorganic agents to induce hyperthermia in GBM. Third, it discusses different methodologies for synthesis of each inorganic agent. Finally, it reviews in vitro and in vivo studies in which MNPs, GNRs, and CNTs have been applied for hyperthermia ablation and drug delivery in GBM. Ključne besede: hyperthermia, targeted drug delivery, SPIONs, gold nanorods, carbon nanotubes Objavljeno v DiRROS: 06.08.2024; Ogledov: 93; Prenosov: 102
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74. Manipulating behaviour with substrate-borne vibrations - potential for insect pest controlJernej Polajnar, Anna Eriksson, Andrea Lucchi, Gianfranco Anfora, Meta Virant-Doberlet, Valerio Mazzoni, 2015, pregledni znanstveni članek Povzetek: This review presents an overview of the potential use of substrate-borne vibrations for the purpose of achieving insect pest control in the context of integrated pest management. Although the importance of mechanical vibrations in the life of insects has been fairly well established, the effect of substrate-borne vibrations has historically been understudied, in contrast to sound sensu stricto. Consequently, the idea of using substrate-borne vibrations for pest control is still in its infancy. This review therefore focuses on the theoretical background, using it to highlight potential applications in a field environment, and lists the few preliminary studies that have been or are being performed. Conceptual similarities to the use of sound, as well as limitations inherent in this approach, are also noted. © 2014 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. Ključne besede: insects, behaviour, pest control, substrate-borne vibrations Objavljeno v DiRROS: 06.08.2024; Ogledov: 116; Prenosov: 94
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75. Using multi-tracer inference to move beyond single-catchment ecohydrology : invited reviewBenjamin W. Abbott, Viktor Baranov, Clara Mendoza-Lera, Mukundh Narayanan Balasubramanian, José Gonçalves, Stefan Krause, 2016, pregledni znanstveni članek Povzetek: Protecting or restoring aquatic ecosystems in the face of growing anthropogenic pressures requires an understanding of hydrological and biogeochemical functioning across multiple spatial and temporal scales. Recent technological and methodological advances have vastly increased the number and diversity of hydrological, biogeochemical, and ecological tracers available, providing potentially powerful tools to improve understanding of fundamental problems in ecohydrology, notably: 1. Identifying spatially explicit flowpaths, 2. Quantifying water residence time, and 3. Quantifying and localizing biogeochemical transformation. In this review, we synthesize the history of hydrological and biogeochemical theory, summarize modern tracer methods, and discuss how improved understanding of flowpath, residence time, and biogeochemical transformation can help ecohydrology move beyond description of site-specific heterogeneity. We focus on using multiple tracers with contrasting characteristics (crossing proxies) to infer ecosystem functioning across multiple scales. Specifically, we present how crossed proxies could test recent ecohydrological theory, combining the concepts of hotspots and hot moments with the Damköhler number in what we call the HotDam framework. Ključne besede: hydrological tracer, environmental hydrology, ecohydrology, aquatic ecology Objavljeno v DiRROS: 06.08.2024; Ogledov: 120; Prenosov: 164
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76. Application of whole genome shotgun sequencing for detection and characterization of genetically modified organisms and derived productsArne Holst-Jensen, Bjørn Spilsberg, Alfred J. Arulandhu, Esther Kok, Jianxin Shi, Jana Žel, 2016, pregledni znanstveni članek Povzetek: The emergence of high-throughput, massive or next-generation sequencing technologies has created a completely new foundation for molecular analyses. Various selective enrichment processes are commonly applied to facilitate detection of predefined (known) targets. Such approaches, however, inevitably introduce a bias and are prone to miss unknown targets. Here we review the application of high-throughput sequencing technologies and the preparation of fit-for-purpose whole genome shotgun sequencing libraries for the detection and characterization of genetically modified and derived products. The potential impact of these new sequencing technologies for the characterization, breeding selection, risk assessment, and traceability of genetically modified organisms and genetically modified products is yet to be fully acknowledged. The published literature is reviewed, and the prospects for future developments and use of the new sequencing technologies for these purposes are discussed. Ključne besede: cisgene, intragene, traceability, traceability, transcriptome sequencing, transgene, unknown GMO Objavljeno v DiRROS: 06.08.2024; Ogledov: 117; Prenosov: 85
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77. Novel therapeutic strategies to target leukemic cells that hijack compartmentalized continuous hematopoietic stem cell nichesVashendriya V. V. Hira, Cornelis J. F. van Noorden, Hetty E. Carraway, Jaroslaw P. Maciejewski, Remco J. Molenaar, 2017, pregledni znanstveni članek Povzetek: Acute myeloid leukemia and acute lymphoblastic leukemia cells hijack hematopoietic stem cell (HSC) niches in the bone marrow and become leukemic stem cells (LSCs) at the expense of normal HSCs. LSCs are quiescent and resistant to chemotherapy and can cause relapse of the disease. HSCs in niches are needed to generate blood cell precursors that are committed to unilineage differentiation and eventually production of mature blood cells, including red blood cells, megakaryocytes, myeloid cells and lymphocytes. Thus far, three types of HSC niches are recognized: endosteal, reticular and perivascular niches. However, we argue here that there is only one type of HSC niche, which consists of a periarteriolar compartment and a perisinusoidal compartment. In the periarteriolar compartment, hypoxia and low levels of reactive oxygen species preserve the HSC pool. In the perisinusoidal compartment, hypoxia in combination with higher levels of reactive oxygen species enables proliferation of progenitor cells and their mobilization into the circulation. Because HSC niches offer protection to LSCs against chemotherapy, we review novel therapeutic strategies to inhibit homing of LSCs in niches for the prevention of dedifferentiation of leukemic cells into LSCs and to stimulate migration of leukemic cells out of niches. These strategies enhance differentiation and proliferation and thus sensitize leukemic cells to chemotherapy. Finally, we list clinical trials of therapies that tackle LSCs in HSC niches to circumvent their protection against chemotherapy. Ključne besede: hematopoietic stem cell niche, hijacking, leukemic stem cells, bone marrow, therapy resistance, leukemia Objavljeno v DiRROS: 06.08.2024; Ogledov: 114; Prenosov: 145
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78. Proteases and cytokines as mediators of interactions between cancer and stromal cells in tumoursBarbara Breznik, Helena Motaln, Tamara Lah Turnšek, 2017, pregledni znanstveni članek Povzetek: Proteolytic enzymes are highly relevant in different processes of cancer progression. Their interplay with other signalling molecules such as cytokines represents important regulation of multicellular cross-talk. In this review, we discuss protease regulation mechanisms of cytokine signalling in various types of cancer. Additionally, we highlight the reverse whereby cytokines have an impact on protease expression in an autocrine and paracrine manner, representing complex feedback mechanisms among multiple members of these two protein families. The relevance of the protease-cytokine axis is illustrated in glioblastoma, where interactions between normal mesenchymal stem cells and cancer cells play an important role in this very malignant form of brain cancer. Ključne besede: cellular cross-talk, glioblastoma, invasion, mesenchymal stem cells, protease-cytokine signalling Objavljeno v DiRROS: 06.08.2024; Ogledov: 117; Prenosov: 76
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79. The hypoxic peri-arteriolar glioma stem cell niche, an integrated concept of five types of niches in human glioblastomaDiana A. Aderetti, Vashendriya V. V. Hira, Remco J. Molenaar, Cornelis J. F. van Noorden, 2018, pregledni znanstveni članek Povzetek: Glioblastoma is the most lethal primary brain tumor and poor survival of glioblastoma patients is attributed to the presence of glioma stem cells (GSCs). These therapy-resistant, quiescent and pluripotent cells reside in GSC niches, which are specific microenvironments that protect GSCs against radiotherapy and chemotherapy. We previously showed the existence of hypoxic peri-arteriolar GSC niches in glioblastoma tumor samples. However, other studies have described peri-vascular niches, peri-hypoxic niches, peri-immune niches and extracellular matrix niches of GSCs. The aim of this review was to critically evaluate the literature on these five different types of GSC niches. In the present review, we describe that the five niche types are not distinct from one another, but should be considered to be parts of one integral GSC niche model, the hypoxic peri-arteriolar GSC niche. Moreover, hypoxic peri-arteriolar GSC niches are structural and functional look-alikes of hematopoietic stem cell (HSC) niches in the bone marrow. GSCs are maintained in peri-arteriolar niches by the same receptor-ligand interactions as HSCs in bone marrow. Our concept should be rigidly tested in the near future and applied to develop therapies to expel and keep GSCs out of their protective niches to render them more vulnerable to standard therapies. Ključne besede: glioblastoma, glioma stem cells, niches, blood vessels, extracellular matrix, tumor microenvironment, hypoxia, therapy resistance, vasculature Objavljeno v DiRROS: 06.08.2024; Ogledov: 253; Prenosov: 90
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80. The role of plasmalemma vesicle-associated protein in pathological breakdown of blood-brain and blood-retinal barriers : potential novel therapeutic target for cerebral edema and diabetic macular edemaEsmeralda K. Bosma, Cornelis J. F. van Noorden, Reinier O. Schlingemann, Ingeborg Klaassen, 2018, pregledni znanstveni članek Povzetek: Breakdown of the blood–brain barrier (BBB) or inner blood–retinal barrier (BRB), induced by pathologically elevated levels of vascular endothelial growth factor (VEGF) or other mediators, can lead to vasogenic edema and significant clinical problems such as neuronal morbidity and mortality, or vision loss. Restoration of the barrier function with corticosteroids in the brain, or by blocking VEGF in the eye are currently the predominant treatment options for brain edema and diabetic macular edema, respectively. However, corticosteroids have side effects, and VEGF has important neuroprotective, vascular protective and wound healing functions, implying that long-term anti-VEGF therapy may also induce adverse effects. We postulate that targeting downstream effector proteins of VEGF and other mediators that are directly involved in the regulation of BBB and BRB integrity provide more attractive and safer treatment options for vasogenic cerebral edema and diabetic macular edema. The endothelial cell-specific protein plasmalemma vesicle-associated protein (PLVAP), a protein associated with trans-endothelial transport, emerges as candidate for this approach. PLVAP is expressed in a subset of endothelial cells throughout the body where it forms the diaphragms of caveolae, fenestrae and trans-endothelial channels. However, PLVAP expression in brain and eye barrier endothelia only occurs in pathological conditions associated with a compromised barrier function such as cancer, ischemic stroke and diabetic retinopathy. Here, we discuss the current understanding of PLVAP as a structural component of endothelial cells and regulator of vascular permeability in health and central nervous system disease. Besides providing a perspective on PLVAP identification, structure and function, and the regulatory processes involved, we also explore its potential as a novel therapeutic target for vasogenic cerebral edema and retinal macular edema. Ključne besede: plasmalemma vesicle-associated protein, blood-brain barrier, blood-retinal barrier, cerebral edema, diabetic macular edema Objavljeno v DiRROS: 06.08.2024; Ogledov: 105; Prenosov: 87
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