21. Effect of electroporation on radiosensitization with cisplatin in two cell lines with different chemo- and radiosensitivitySimona Kranjc Brezar, Maja Čemažar, Alenka Grošel, Živa Pipan Tkalec, Gregor Serša, 2003, izvirni znanstveni članek Povzetek: Aim. Radiosensitization with cisplatin can be enhanced by electroporation of cells and tumours. The aim of this study was to extend our previous studies ontwo carcinoma tumour models with different chemo-and radiosensitivity in order to evaluate whether this treatment is effective also on less chemo-and radiosensitive tumour cells. Materials and methods. This in vitro study was performed on carcinoma SCK and EAT-E cells. The cytotoxicity of three-modalitytreatment consisting of cisplatin, electroporation and irradiation was determined by the clonogenic assay. Results. The radiosensitizing effect of cisplatin on the two cell lines was greatly enhanced by electroporation. By this combined treatment, less chemo and radiosensitive EAT-E cells were rendered as sensitive as more chemo and radiosensitive SCK cells. Conclusion. The enhancement of cisplatin-induced radiosensitization of cells by electroporation could be beneficially used in the treatment of intrinsically less chemo- and radiosensitive tumours.
Objavljeno v DiRROS: 06.02.2024; Ogledov: 203; Prenosov: 46
 Celotno besedilo (144,48 KB) |
22. Cryosurgery combined with radiotherapy of tumors in miceAlbert-Peter Fras, Simona Kranjc Brezar, Maja Čemažar, Gregor Serša, 1999, izvirni znanstveni članek Povzetek: Tlle aim of this study zuas to determine antitumor effectiveness of cryosurgery alone and in comhination with radiotherapy. Cryosurgery of subcutaneous fibrosarcoma SA-1 tumors in A/J mice was moderately effective trcatmcnt. Tumor growth delay was 10.3 * 3.8 days after 5 minute treatment with nitrogen filled cryo-prohe. Shorter treatment times induced less, but dose dependent antitumor effect. In combined treat- ment, tumors were either first treated by cryosurgery for 3 minutes and then locally irradiated with 10Gy for 5 minutes, or irradiated first and thereafter treated by cryosurgery.The antitumor effectiveness of com- bined treatrnent was sequence dependent; the irradiation of tumors before cryosurgery resulted in better antitumor effect than the irradiation after cryosurgery. These results indicate that radiosensitization may not be always expected, in spite of some reports demonstrating that cryosurgery may have radiosensitizing effect in vivo, and that some other mechanisms may be involved contributing to radiationdamage when cryosurgery follows irradiation.
Objavljeno v DiRROS: 22.01.2024; Ogledov: 236; Prenosov: 56
Celotno besedilo (311,91 KB) |
23. Prognostic relevance of urokinase plasminogen activator and its inhibitors in patients with breast cancerSimona Borštnar, Tanja Čufer, Ivan Vrhovec, Zvonimir Rudolf, 1999, izvirni znanstveni članek Povzetek: Urokinase plasminogen activator (uPA) and its inhibitors, PAI-1 and PAI-2, play an important role in iritercellular tissue degradation, thus promoting tumor cell invasion into the adjoining structures and metastasizing. Our studywas aimed to assess a possible prognostic value of uPA, PAI-1 and PAI-2 in a retrospective series of 87 patients with breast cancer stage I-III, whosecytosols were stored in the archives of the, Institute of Oncology in Ljubljana. The median follow-up was 35 months. The prognostic value of the established prognostic factors and uPA, PAI-1 and PAI-2 were evaluated by means of univariate statistical analysis and partial multivariate models. The obtained uPA values were very low and did not correlate with the disease free survival, whereas PAI-1 and PAI-2 significantly influenced the time to the first recurrence. Patients with PAI-1 values above 5 ng/mg proteins had statistically significantly worse disease free survival than the patients withlower PAI-1 values (58% vs. 85%). In the case of PAI-2, the situation wasjust the opposite: the patients with PAI-2 values exceeding 6.4 ng/mg proteins had statistically significantly better 3-year disease free survival than the patients with lower values (90% vs. 60%). Both, PAI-1 and PAl-2 retained their independent prognostic value, irrespective of the addition of the established prognostic factors to partial multivariate models, and only with locally advanced disease the prognostic value of PAI-1 was greater than that of PAI-2.
Objavljeno v DiRROS: 22.01.2024; Ogledov: 227; Prenosov: 54
Celotno besedilo (548,70 KB) |
24. The urokinase-type plasminogen activator, its inhibitors and its receptor - the new prognostic factors in solid cancersSimona Borštnar, Tanja Čufer, Zvonimir Rudolf, 1997, pregledni znanstveni članek Povzetek: The urokinase-type plasminogen activator (uPA), its inhibitors (PAI-1 and PAI-2) and its receptor (uPAR) play nan important role in the degradation of the intercellular tissue, the process which affects the ability of cancer cells to invade to surrounding tissue and to metastasize. The results of clinical studies performed in the past few years point out a significant influence of uPA, PAI-1, PAI-2 and uPAR on the course of the disease and survival of patients with solid tumours, particularly breast cancer. Hopefullythe categorization of patients according to the content of the serineproteases and its inhibitors in tumour tissues could provide a basis formore rational treatment planning and thus improving patients' survival.
Objavljeno v DiRROS: 18.01.2024; Ogledov: 215; Prenosov: 55
Celotno besedilo (485,80 KB) |
25. |
26. Differential diagnosis between bone metastases and osteomalaciaBranko Zakotnik, Simona Borštnar, Tadeja Movrin, Boris Jančar, Andreja Zidar, 1996, izvirni znanstveni članek Povzetek: In oncology the diagnosis of skeletal metastases is a frequent one, in infact so frequent that other diagnoses such as metabolic bone diseases affecting patients with cancer may be overlooked. In our report two cases of osteomalacia referred to an oncologist are presented; in both of them the diagnosis of diffuse bone metastases of unknown origin was suspected. The differential diagnosis is discussed and the importance of bone marrow biopsy using Yamshidi needle for diagnosis of metabolic bone disease is emphasized.
Objavljeno v DiRROS: 16.01.2024; Ogledov: 229; Prenosov: 50
Celotno besedilo (318,84 KB) |
27. Overview of the thermal properties of rocks and sediments in SloveniaDušan Rajver, Simona Adrinek, 2023, pregledni znanstveni članek Povzetek: The use of geothermal energy, which comes from both deep geothermal systems and the shallow underground, has been developing rapidly in the last few decades. The purpose of the paper is to present the results of measurements of the thermal properties of all rock samples and sediments that were available from boreholes, two tunnels and numerous surface locations in Slovenia in the period from 1982 to the end of 2022. In relation to the shallow geothermal potential, a special effort is needed to characterize the thermal properties of the rocks and sediments and to implement thermal energy transfer technology. In this sense, knowledge of the thermal conductivity of rocks and sediments is required to assess the possibility of low-enthalpy heat exchange in a given local area. The largest number of measurements was taken to determine thermal conductivity. Determinations of thermal diffusivity were carried out on a much smaller number of rock and sediment samples, as well as determinations of radiogenic heat production in rocks. The results of thermal conductivity measurements on 430 samples from 119 wells, 20 samples from two tunnels and 156 samples from surface locations are shown. The highest thermal conductivities are shown by samples of dolomite, quartz conglomerate and conglomerate, phyllonite, quartz phyllite and gneiss, while the lowest are measured in sediments such as clay, lignite with clay, peat and dry sand. The determined radioactive heat generation is the lowest for milonitized dolomite and highest for dark grey sandstone with shale clasts. Our results are comparable to those already published worldwide, and they could be the basis for the possible future Slovenian standard for the thermal properties of measured rocks and sediments.
Ključne besede: thermal conductivity, thermal diffusivity, borehole, tunnel, surface, rock, sediment, radioactive heat generation, Slovenia
Objavljeno v DiRROS: 15.01.2024; Ogledov: 248; Prenosov: 117
Celotno besedilo (6,03 MB)
Gradivo ima več datotek! Več... |
28. |
29. Heavy minerals as indicators of source material in soils on carbonatesBarbara Čeplak, Miloš Miler, Nina Zupančič, Simona Jarc, 2023, izvirni znanstveni članek Povzetek: The origin of the soils formed on carbonate rocks remains uncertain, as they are probably of polygenetic origin. Of particular interest are the elevated contents of some trace elements detected in these soils, as they can hardly be attributed to insoluble residues of carbonate rock. The aim of this study was to uncover the relationship between heavy minerals in bedrock and soil and to identify other sources that influence the mineral and chemical composition of soil. We investigated representative samples of soils and dolomite bedrock as well as sandstones and marlstones from the nearby flysch basin as an expected source of the aeolian contribution. XRD and SEM/EDS showed that mineral diversity is higher in soils compared to the dolomites. Heavy minerals found in dolomite insoluble residue include sphalerite, Ti-oxide (probably rutile), zircon, fluorite, pyrite, minerals of REE phosphates and apatite group, interpreted as terrigenous detrital material. The mineral composition of soil heavy fraction is only partly following insoluble residues of bedrock and indicates possible aeolian contribution. Comparison with nearby flysch sandstones and marlstones showed similarities in mineralogical diversity by the presence of chromite and Fe-Cr(Mn) oxides (probably carmichaelite). Other minerals present in soils and flysch layers, such as Ti-oxide (probably rutile), zircon, REE phosphates, and pyrite grains, however, show similarities in mode of occurrence and transport indications. Signs of aeolian transport on the grains detected in soils were further confirmed by SEM/EDS.
Ključne besede: Phaeozem, Upper Triassic dolomite, flysch layers, trace elements, SEM/EDS
Objavljeno v DiRROS: 04.01.2024; Ogledov: 297; Prenosov: 64
Celotno besedilo (8,60 MB) |
30. |
