1191. Comparison of colorimetric MTT and clonogenic assays for irradiation and cisplatin treatment on murine fibrosarcoma SA-1 cellsMaja Čemažar, Darja Marolt, Mira Lavrič, Gregor Serša, 1999, original scientific article Abstract: Background. The aim of our study was to determine the relationship between cell survival of SA-1 tumor cells measured by clonogenic assay and MTT assay after irradiation and cisplatin treatment. Materials and methods. Survival of SA-1 cells was measured after irradiation (2-8 Gy) and cisplatin treatment (0.05-0.5 u g/ml) by clonogenic assay performed 7 days after treatment, and byMTT assay performed on day 3, 4, 5, and 7 after the treatment. Results. The results showed good correlation between MTT assay and clonogenic assay for irradiation doses below 4 Gy. For higher doses good correlation between MTT and clonogenic assay was determined only when MTT assay was performed on day 5and 7 after the treatment. In the case of cisplatin treatment, similar pattern was observed, good correlation between IC50 values for MTT and clonogenic assay was found when MTT assay was performed on day 5 and 7 after the treatment. Conclusion. Results of our study confirmed the results of previous studies addressing this topic and further support the use of MTT testas an alternative test for clonogenic test as a predictive assay of tumourresponse to the radio or chemotherapy.
Published in DiRROS: 22.01.2024; Views: 294; Downloads: 63
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1192. Adenocarcinoma skin metastases treated by electrochemotherapy with cisplatin combined with radiationGregor Serša, Maja Čemažar, Zvonimir Rudolf, Albert-Peter Fras, 1999, original scientific article Abstract: Background. The aim of this study was to determine the interaction between electrochemotherapy as a means of facilitated cisplatin delivery into the cells and irradiation of adenocarcinoma skin metastases. Case report. A patient with progressive disease presenting skin metastases of tubal dedifferentiated pappilary adenocarcinoma was enrolled in the study. Skin metastases were treated by electrochemotherapy with intratumoral injection of cisplatin. Its antitumor effectiveness was compared to that of combined treatment of irradiation with electrochemotherapy. After a two week observation time, the response to treatment was comparable between the electrochemotherapy and electrochemotherapy combined with irradiation. Both ofthese treatments were more effective than irradiation alone. Furthermore, antitumor effectiveness of the combined electrochemo- and radiotherapy was found to be quicker than that of electrochemotherapy alone. Comment. This study shows that electrochemotherapy with cisplatin is also effective in the treatment of adenocarcinoma skin metastases. Inspite of the short observation time, positive interaction between radiotherapy and electrochemotherapy with cisplatin was found.
Published in DiRROS: 22.01.2024; Views: 265; Downloads: 71
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1193. Acute subarachnoid haemorrhage : detection of aneurysms of intracranial arteries by computed tomographic angiographyZoran Miloševič, 1999, original scientific article Abstract: Background. We wanted to determine the diagnostic accuracy, sensitivity and specificity of computed tomographic angiography (CTA) of intracranial vessels,and to establish the advantages and disadvantages of CTA compared to digital subtraction angiography (DSA) as the gold standard in patients with acute subarachnoid haemorrhage (SAH). Patients and methods. We prospectively studied 52 patients with acute SAH. Confirmation of the haemorrhage by a conventional computed tomography (CT) scan was immediately followed by intracranial CTA. DSA was performed after the CTA examination and so did not influence the interpretation of CTA images. The sensitivity, specificity and diagnostic accuracy of CTA were determined by comparing the results with the data from DSA and with the surgical findings. Cases where the CTA and DSA results did not match were analysed, and the advantages and disadvantages of intracranial CTA were determined. Results. The diagnostic accuracy of CTA was 95%, its sensitivity was 93%, and its specificity was 98%. False-negative results were obtained in three patients who harboured small aneurysms, two in the region of the cavernous sinus and one at the division of pericallosal and callosomarginal arteries. In one patient with a false-positive result, DSA showed an infundibular widening of the posterior communicating artery. In all seven patients who underwent operations on the basis of CTA results, the surgical findings confirmed the presence of aneurysms as well as the intracranial vessel anatomy demonstrated by CTA. Conclusions. Intracranial CTAis a fast and minimally invasive method with a high diagnostic accuracy, sensitivity and specificity, which has an important place in the detection andpreoperative evaluation of intracranial aneurysms in patients with acute SAH.
Published in DiRROS: 22.01.2024; Views: 224; Downloads: 55
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1194. Ultrasound in diagnosis and treatment of anal fistulasPavle Košorok, 1999, original scientific article Abstract: Buckground. Endoanal ultrasound (EUS) is helpful in the diagnosis of anorectalfistulas and abscesses due to its high resolution image quality and anatomical orientation using a radial scanning echoprobe. This type of information is essential in monitoring the response to treatment. Initial EUS examination prior to treatment, is mandatory in order to compare the results before and after treatment. Intraoperative EUS may also be helpful if the lesion is deep beyond the pelvic floor muscle which may not be seen during surgery. Better results in EUS imaging of perianorectal fistulas can be obtained using hydrogen peroxide as a contrast medium. Concomitant advantage of hydrogen peroxide ultrasound was the detection of suspected or unsuspected sphincter defects. However, interobserver reliability has to be taken into account together with the learning curve of a particular observer. Conclusions. Endoanal US is a safe, economic, and reliable procedure for the assessment of fistula-in-ano, and is superior to physical examination.
Published in DiRROS: 22.01.2024; Views: 235; Downloads: 53
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1197. How reliable is classic chest radiography in the diagnosis of small pleural effusionIgor Kocijančič, Ksenija Kocijančič, 1999, original scientific article Abstract: Purpose. To evaluate the usefulness of expirium lateral decubitus views in theradiological diagnosis of small pleural effusions. Materials and methods. Patients referred to abdominal sonography for different reasons were routinelychecked for possible pleural effusion. From November 1994 till May 1996, 36 such patients were found to have pleural effusion not exceeding 15 mmand were included in the study. Patients were examined radiologically in erect PA and lateral projections and, after 5 min. in decubitus position, in inspiratory-expiratory lateral decubitus projections with 10 hip elevation andcentral beam on the lateral chest wall. Results. In 22 out of 36 patients (61 %), the pleural fluid was not visible on erect PA and lateral chest radiogram. However, the fluid was visible in 35/36 patients (97%) in expirium from lateral decubitus view. The average thickness of fluid from lateral decubitus views in inspirium and expirium was 4.3 and 7.9 mm, respectively. In31 out of 36 patients (86%), the thickness of the fluid layer as measured inexpirium and inspirium was different. In 16%, the fluid was not visible on inspirium lateral decubitus projections. Conclusions. Radiography turned out to be almost as sensitive as sonography in detection of small pleural effusions. Lateral decubitus views taken in expirium contributed essentially to the diagnostic sensitivity in our study.
Published in DiRROS: 22.01.2024; Views: 251; Downloads: 66
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1198. Cryosurgery combined with radiotherapy of tumors in miceAlbert-Peter Fras, Simona Kranjc Brezar, Maja Čemažar, Gregor Serša, 1999, original scientific article Abstract: Tlle aim of this study zuas to determine antitumor effectiveness of cryosurgery alone and in comhination with radiotherapy. Cryosurgery of subcutaneous fibrosarcoma SA-1 tumors in A/J mice was moderately effective trcatmcnt. Tumor growth delay was 10.3 * 3.8 days after 5 minute treatment with nitrogen filled cryo-prohe. Shorter treatment times induced less, but dose dependent antitumor effect. In combined treat- ment, tumors were either first treated by cryosurgery for 3 minutes and then locally irradiated with 10Gy for 5 minutes, or irradiated first and thereafter treated by cryosurgery.The antitumor effectiveness of com- bined treatrnent was sequence dependent; the irradiation of tumors before cryosurgery resulted in better antitumor effect than the irradiation after cryosurgery. These results indicate that radiosensitization may not be always expected, in spite of some reports demonstrating that cryosurgery may have radiosensitizing effect in vivo, and that some other mechanisms may be involved contributing to radiationdamage when cryosurgery follows irradiation.
Published in DiRROS: 22.01.2024; Views: 277; Downloads: 77
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1199. Ultrasonographic diagnnosis of obstructive ileus in a patient with Meckel's diverticulumAlenka Višnar-Perovič, Aleš Koren, 1999, original scientific article Abstract: Introduction. Despite the use of modern imaging techniques, the reliable preoperative assessment of Meckel's diverticulurn and related complications with this rare congenital anomaly of the gastrointestinal tract in adults is uncomrnon. Case presentation. This report presents the case of a 25 year old man who presented with a sudden onset of pain in the right lower abdomen and vomiting. On clinical examination the affected area was tender to palpation which revealed an elastic cylindrical formation situated deeply in the abdomen. Blumberg's sign was positive while the laboratory findings were stillwithin normal limits. An ultrasonography of the abdomen revealed an ileocaecal fluid collection containing thicker residue, which was suspicious for Meckel's diverticulum or a duplication cyst and ileus of the small bowel proximally from the formation described. Native radiogram of the abdomen in supine position has confirmed the presence of obstructive ileus at the level of the distal part of the small bowel. Surgery revealed an ileus and compression of the distal part of the small bowel due to the presence of an edematous Meckel's diverticulum. Conclusion. In view of the frequent use of ultrasonography in the evaluation of acute ahdomen, the diagnostic procedures could be rationalized and the time to surgery reduced if possible complicatioris due to Meckel's diverticulum would he considered in the differential diagnosis.
Published in DiRROS: 22.01.2024; Views: 242; Downloads: 57
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1200. Manual for use of Al-containing residues in low-carbon mineral bindersSabina Dolenec, Katja Malovrh Rebec, Anja Lešek, Katarina Šter, Lea Žibret, Gorazd Žibret, Klemen Teran, Emil Pučko, Ildikó Merta, Bojan Poletanovic, Elena Yaneva, Peter Kesserű, Ildikó Kovács, Bence Kószó, Alexandra Németh, Richard Laucournet, Mustafa Hadžalić, Emilija Fidanchevski, Biljana Angjusheva, Vojo Jovanov, Miloš Nenadović, Snežana B. Nenadović, Ivana Vukanac, Liljana Kraljević, Mojca Loncnar, Andrej Ipavec, 2020, dictionary, encyclopaedia, lexicon, manual, atlas, map Abstract: Današnje družbe si ni več mogoče predstavljati brez sodobne infrastrukture, ki temelji na uporabi različnih materialov ter zahteva veliko porabo energije. Vzporedno s proizvodnjo materialov, nastajajo ogromne količine različnih industrijskih in rudarskih ostankov (odpadki/stranski proizvodi), ki jih trenutno ne izkoriščamo, sama odlagališča pa so premalo raziskana. Cilj Evropske unije (EU) je povečati učinkovito rabo virov in ponudbo sekundarnih surovin z recikliranjem, popisom odpadkov iz rudarskih in drugih industrijskih dejavnosti ter njihova ponovna uporaba. Veliko industrijskih in rudarskih odpadkov je obogatenih z aluminijem (Al), zato lahko nadomeščajo naravne vire Al v mineralnih veznih, vendar njihova uporaba zahteva obsežno poznavanje njihovih kemijskih, mineraloških, radioloških in fizikalnih lastnosti. Priročnik, ki so ga pripravili partnerji projekta RIS-ALiCE obravnava zakonodajne vidike, ki urejajo uporabo sekundarnih surovin v gradbenih proizvodih, opis najpogostejših industrijskih in rudarskih ostankov, ki vsebujejo Al (nahajališča boksitov, rdeče blato, jeklarske žlindre, pepeli iz različnih industrij, itd.), potencial njihove ponovne uporabe in njihov ekonomski vidik, potencialne zahteve/ovire za uporabo sekundarnih surovin v cementni industriji in opis belitno-sulfoaluminatnih cementov, ki so obetavna rešitev za izvajanje krožnega gospodarstva z uporabo velikih količin odloženih industrijskih in rudarskih odpadkov, bogatih z Al.
Keywords: gradbeni proizvodi, ponovna uporaba, ekonomski vidik, industrija cementa, krožno gospodarstvo, industrijski odpadki, zakonodaja, elektronske knjige
Published in DiRROS: 22.01.2024; Views: 340; Downloads: 165
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