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Abstract: Standard treatment for patients with inoperable locally advanced non-small cell lung cancer (NSCLC) is concurrent chemoradiotherapy (CCRT). Five-year overall survival rates range between 15 and 25%, while long term survival data are rarely reported. Patients and methods A total of 102 patients with stage III NSCLC treated between September 2005 and November 2010 with induction chemotherapy and CCRT were included in this long term survival analysis. All patients were tested for PD-L1 status and expression of PD-L1 was correlated with overall survival (OS), progression free survival (PFS) and toxicities. Results The median OS of all patients was 24.8 months (95% CI 18.7 to 31.0) with 10 year-survival rate of 11.2%. The median OS of patients with PD-L1 expression was 12.1 months (95% CI 0.1 to 26.2), while in patients with negative or unknown PD-L1 status was significantly longer, 25.2 months (95% CI 18.9 to 31.6), p = 0.005. The median PFS of all patients was 16.4 months (95% CI 13.0 to 19.9). PFS of patients with PD-L1 expression was 10.1 months (95% CI 0.1 to 20.4) and in patients with negative or unknown PD-L1 status was 17.9 months (95% CI 14.2 to 21.7), p = 0.003. Conclusions 10-year overall survival of stage III NSCLC patients after CCRT is 11.2%. PFS and OS differ with regard to PD-L1 status and are significantly shorter for patients with PD-L1 expression. New treatment with check-point inhibitors combined with RT therefore seems reasonable strategy to improve these results.
Keywords: NSCLC, non-small cell lung cancer, locally advanced, immunotherapy, chemoradiotherapy
Published in DiRROS: 10.06.2024; Views: 346; Downloads: 151
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Keywords: matrix metalloproteinases, mesothelioma, biomarkers, malignant pleural mesothelioma
Published in DiRROS: 10.06.2024; Views: 373; Downloads: 81
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Keywords: chemoradiotherapy, radiothreapy, colorectal cancer
Published in DiRROS: 10.06.2024; Views: 244; Downloads: 156
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Abstract: The ostracod assemblages from the Upper Permian and Permian-Triassic transitional strata of the Masore section in the External Dinarides (Slovenia) were studied. Altogether 13 genera and 20 species of the orders Palaeocopida, Platycopida and Podocopida are identified and illustrated. All recovered ostracods belong to shallow marine taxa. The older fauna from the uppermost Permian and the younger fauna from the Permian-Triassic boundary strata are distinguished. The obtained fauna from the Permian Bellerophon Formation corresponds to the “benthonic ostracod Eifelian Mega-assemblage” occupying the shelf sea floors. This study presents the first report of ostracod faunas from the uppermost Permian and Permian-Triassic boundary interval of Slovenia. The recovered ostracod fauna display a distinct faunal change and yield important paleobiogeographic implications as it reveals similarity with stratigraphical equivalent faunas from some other neighboring localities in the western Paleotethys, such as Bulla in Italy, Komirić in Serbia, and the Bükk Mountains in Hungary.
Keywords: microfauna, Changhsingian, Permian-Triassic boundary strata, Dinarides
Published in DiRROS: 10.06.2024; Views: 282; Downloads: 125
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Abstract: This geospatial dataset provides a compilation of findings from an evidence-based review of site-specific resource assessments of mining and metallurgical residues. Information pertaining to location, target material, geological knowledge, extractability, resource classification and stakeholder perspectives was collected from publicly available reports, articles, academic theses, and databases. The dataset includes 44 relevant data attributes from 64 mining and metallurgical sites in 27 countries. Resource classification is available for 38 sites. The dataset can be used by evaluators of recovery projects, authorities that provide permits, as well as by decision makers in support of developing regulatory policies. The dataset facilitates future addition of sites by the research community and can be further used as a starting point to bridge the estimates on recoverable quantities to the United Nations Framework Classification (UNFC). The UNFC is a universally applicable scheme for the sustainable management of all energy, primary and secondary mineral resources. Its use is stimulated by the European Commission and is intended to be adopted by geological surveys to harmonize the data on the availability of primary and secondary raw materials in Europe in future.
Keywords: resources, reserves, mining waste, secondary raw materials, tailings, geodatabase, circular economy, resource assessment
Published in DiRROS: 10.06.2024; Views: 268; Downloads: 179
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