1951. Intrahepatic cauda/inferior vena cava interruption with azygos/hemiazygos continuation. Vascular anomaly in swineMiran Jeromel, Dušan Pavčnik, 2010, original scientific article Abstract: Background. Electrochemotherapy is a local treatment combining application of electric pulses and chemotherapy. Two chemotherapeutic drugs, bleomycin and cisplatin, have proved to be effective in electrochemotherapy. The effectiveness of electrochemotherapy was demonstrated in the treatment of various cutaneous and subcutaneous tumours in cancer patients. Only a few preclinical studies were performed in colorectal carcinoma, mostly using bleomycin. Our aim was to evaluate the sensitivity of the murine colorectal carcinoma cell line CMT-93 to electrochemotherapy with bleomycin and cisplatinfor potential use in preclinical and clinical studies. Methods. CMT-93 cells were exposed to either the chemotherapeutic drug alone or electrochemotherapy. A clonogenic assay was used to determine cell survival after treatment. Apoptosis was measured by caspase-3/7 activity, necrosis by changes in cell morphology and cell viability by the MTS assay 16 hours after electrochemotherapy. Results. Cells treated with electrochemotherapy were 500-fold more sensitive to bleomycin and 2.8-fold more sensitive to cisplatin compared to cells treated with the drugs alone. At the highest concentrations,a significant reduction in cell viability, increase in caspase-3/7 activity and necrotic cells were observed after electrochemotherapy. Conclusions. Exposure of cells to electric pulses enhanced cytotoxicity of both bleomycin and cisplatin. Reduced cell viability was due to apoptotic and necrotic cell death. Furthermore, electrochemotherapywith bleomycin was more cytotoxic than electrochemotherapy with cisplatin in this colorectal carcinoma cell line. Published in DiRROS: 18.03.2024; Views: 428; Downloads: 100 Full text (1,02 MB) |
1952. Cubic vertex-transitive graphs admitting automorphisms of large orderPrimož Potočnik, Micael Toledo, 2023, original scientific article Abstract: A connected graph of order $n$ admitting a semiregular automorphism of order $n/k$ is called a $k$-multicirculant. Highly symmetric multicirculants of small valency have been extensively studied, and several classification results exist for cubic vertex- and arc-transitive multicirculants. In this paper, we study the broader class of cubic vertex-transitive graphs of order $n$ admitting an automorphism of order $n/3$ or larger that may not be semiregular. In particular, we show that any such graph is either a $k$-multicirculant for some $k \le 3$, or it belongs to an infinite family of graphs of girth $6$. Keywords: cubic vertex-transitive graphs, multicirculants, automorphisms of large order Published in DiRROS: 18.03.2024; Views: 422; Downloads: 184 Full text (929,04 KB) This document has many files! More... |
1953. Evaluation of clinical interventions made by pharmacists in chemotherapy preparationLea Knez, Raisa Laaksonen, Catherine Duggan, 2010, original scientific article Abstract: Background. Cancer drugs are high risk drugs and medication errors in their prescribing, preparation and administration have serious consequences, including death. The importance of a multidisciplinary approach and the benefits of pharmacistsć contribution to cancer treatment to minimise risk have been established. However, the impact of services provided by pharmaciststo cancer patient care is poorly studied. This study explored the clinical interventions made by pharmacists in dispensing of chemotherapy doses, and evaluated pharmacistsć contribution to patient care. Methods. Pharmacists at the Chemotherapy Preparation Unit at a tertiary cancer centre in London were shadowed by two research pharmacists during the clinical screening of chemotherapy prescriptions and release of prepared drugs. An expert panel of pharmacy staff rated the clinical significance of the recordedinterventions. Results. Twenty-one pharmacistsć interventions were recorded during the screening or releasing of 130 prescriptions or drugs. ĆDrug and therapyĆ (38%), ĆclericalĆ (22%) and Ćdose, frequency and durationĆ (19%) related problems most often required an intervention, identifying areas in chemotherapy prescribing that need improvement. The proposed recommendations were implemented in 86% of the cases. Many recorded interventions (48%) were ranked to have had a Ćvery significantĆ influence on patient care. Conclusion. Clinical interventions made by pharmacists had a significant impact on patient care. The integration of pharmacistsć technical and clinical roles into dispensing of chemotherapy doses is required for providing high-quality cancer services. Published in DiRROS: 18.03.2024; Views: 363; Downloads: 123 Full text (452,60 KB) |
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1955. Bordering of symmetric matrices and an application to the minimum number of distinct eigenvalues for the join of graphsAida Abiad, Shaun M. Fallat, Mark Kempton, Rupert H. Levene, Polona Oblak, Helena Šmigoc, Michael Tait, Kevin N. Vander Meulen, 2023, original scientific article Keywords: inverse eigenvalue problem, minimum number of distinct eigenvalues, borderings, joins of graphs, paths, cycles, hypercubes Published in DiRROS: 18.03.2024; Views: 529; Downloads: 213 Full text (485,46 KB) This document has many files! More... |
1956. Antigen expression on recurrent meningioma cellsAndrej Vranič, 2010, original scientific article Abstract: Introduction. Meningiomas are intracranial brain tumours that frequently recur. Recurrence rates up to 20% in 20 years for benign meningiomas, up to 80% for atypical meningiomas and up to 100% for malignant meningiomas, have been reported. The most important prognostic factors for meningioma recurrenceare meningioma grade, meningioma invasiveness and radicality of neurosurgical resection. The aim of our study was to evaluate the differences in antigenic expression on the surface of meningioma cells between recurrent and non-recurrent meningiomas. Methods. 19 recurrent meningiomas and 35 non-recurrent meningiomas were compared regarding the expression of MIB-1 antigen, progesterone receptors, cathepsin B and cathepsin L, using immunohistochemistry. Results. MIB-1 antigen expression was higher in the recurrent meningioma group (p=0.001). No difference in progesterone receptor status between recurrent and non-recurrent meningiomas was confirmed. Immunohistochemical intensity scores for cathepsin B (p= 0.007) and cathepsin L (p<0.001) were both higher in the recurrent than in the non-recurrent meningioma group. Conslusions. MIB-1 antigen expression is higher in recurrentcompared to non-recurrent meningiomas. There is no difference in expression of progesterone receptors between recurrent and non-recurrent meningiomas. Cathepsins B and L are expressed more in recurrent meningiomas. Published in DiRROS: 15.03.2024; Views: 400; Downloads: 129 Full text (956,01 KB) |
1957. Study of radiation induced changes of phosphorus metabolism in mice by ▫$^{31}P$▫ NMR spectroscopyIgor Serša, Simona Kranjc Brezar, Gregor Serša, Alenka Nemec Svete, Bojan Ložar, Ana Sepe, Jernej Vidmar, Marjeta Šentjurc, 2010, original scientific article Published in DiRROS: 15.03.2024; Views: 435; Downloads: 159 Full text (699,32 KB) |
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1960. Genetic markers in oligodendroglial tumoursTomaž Velnar, Uroš Smrdel, Mara Popović, Gorazd Bunc, 2010, review article Abstract: Background. Oliogodendrogliomas are brain tumours composed of the cells resembling oligodendrocytes. They represent the third most common glial tumour, comprising 2.5% of all primary brain tumours and 5-20% of all gliomas. Conclusions. Oligodendroglial tumours with 1p and 19q loss demonstrate a better overall prognosis due to more indolent clinical behaviour and higher sensitivity to treatment. Additionally, 1p and 19q loss is a marker of clinical utility, helping to assess tumour sensitivity to chemotherapy and harbouring the potential for improving the diagnosis and survival of oligodendroglioma patients as well as future clinical practice. Published in DiRROS: 15.03.2024; Views: 424; Downloads: 124 Full text (616,34 KB) |