261. Timeline of leaf and cambial phenology in relation to development of initial conduits in xylem and phloem in three coexisting sub-Mediterranean deciduous tree speciesJožica Gričar, Andreja Vedenik, Gregor Skoberne, Polona Hafner, Peter Prislan, 2020, original scientific article Abstract: It is unclear how the anticipated climate change will affect the timing of phenology of different tree organs/tissues and thus the whole-tree functioning. We examined the timing of leaf phenology and secondary growth in three coexisting deciduous tree species (Quercus pubescens Willd., Fraxinus ornus L. and Ostrya carpinifolia Scop) from a sub-Mediterranean region in 2019. In addition, we investigated the relationship between leaf and cambial phenology and the onset of the potential functioning of initial conduits, as determined by the completed differentiation process (vessels) or final size (sieve tubes). For this purpose, leaf development was monitored and the microcores of cambium and the youngest phloem and xylem increments were repeatedly collected at 7-10-day intervals during the growing season. The results revealed differences in the timing of leaf development and seasonal radial growth patterns in spring among the studied tree species, depending on wood porosity. We found that cambial cell production started in all cases in the first half of March. However, in ring-porous Q. pubescens and F. ornus, radial growth in the stem occurred more than a month before buds were swollen, whereas in diffuse-porous O. carpinifolia, these two events were detected at almost the same time. The end of cambial cell production occurred earliest in F. ornus (mid-July) and two weeks later also in the other two species. The widest initial earlywood vessels and early phloem sieve tubes were found in Q. pubescens, the narrowest initial earlywood vessels in O. carpinifolia and the narrowest early phloem sieve tubes in F. ornus. This indicates differences in the e%ciency of conducting systems among the studied species. This novel approach of studying phloem phenology and anatomy in relation to leaf and xylem development contributes to a better understanding of how different tree species adapt their structure of secondary vascular tissues in response to environmental change.
Keywords: Quercus pubescens, Fraxinus ornus, Ostrya carpinifolia, earlywood, early phloem, vessel, sieve tube, radial growth
Published in DiRROS: 21.10.2020; Views: 1282; Downloads: 932
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262. Prevalence of and factors associated with healthcare-associated infections in Slovenian acute care hospitals : results of the third national surveyIrena Klavs, Mojca Serdt, Aleš Korošec, Tatjana Lejko-Zupanc, Blaž Pečavar, 2019, original scientific article Abstract: Introduction. In the third Slovenian national healthcare-associated infections (HAIs) prevalence survey, conducted within the European point prevalence survey of HAIs and antimicrobial use in acute care hospitals, we estimated the prevalence of all types of HAIs and identified factors associated with them. Methods. Patients were enrolled into a one-day cross-sectional study in November 2017. Descriptive analyses were performed to describe the characteristics of patients, their exposure to invasive procedures and the prevalence of different types of HAIs. Univariate and multivariate analyses of association of having at least one HAI with possible risk factors were performed to identify risk factors. Results. Among 5,743 patients, 4.4% had at least one HAI and an additional 2.2% were still treated for HAIs on the day of the survey, with a prevalence of HAIs of 6.6%. The prevalence of pneumoniae was the highest (1.8%), followed by surgical site infections (1.5%) and urinary tract infections (1.2%). Prevalence of blood stream infections was 0.3%. In intensive care units (ICUs), the prevalence of patients with at least one HAI was 30.6%. Factors associated with HAIs included central vascular catheter (adjusted odds ratio [aOR] 4.1; 95% confidence intervals [CI]: 3.1–5.4), peripheral vascular catheter (aOR 3.0; 95% CI: 2.3–3.9), urinary catheter (aOR 1.8; 95% CI: 1.4–2.3). Conclusions. The prevalence of HAIs in Slovenian acute care hospitals in 2017 was substantial, especially in ICUs. HAIs prevention and control is an important public health priority. National surveillance of HAIs in ICUs should be developed to support evidence-based prevention and control.
Keywords: healthcare-associated infections, prevalence, survey, risk factors, Slovenia
Published in DiRROS: 16.10.2020; Views: 2440; Downloads: 899
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263. Expression of FGFR1-4 in malignant pleural mesothelioma tissue and corresponding cell lines and its relationship to patient survival and FGFR inhibitor sensitivityGregor Vlačić, Mir Alireza Hoda, Thomas Klikovits, Katharina Sinn, Elisabeth Gschwandtner, Katja Mohorčič, Karin Schelch, Christine Pirker, Barbara Peter-Vörösmarty, Jelena Brankovic, Tanja Čufer, Aleš Rozman, Izidor Kern, 2019, original scientific article Abstract: Malignant pleural mesothelioma (MPM) is a devastating malignancy with limited therapeutic options. Fibroblast growth factor receptors (FGFR) and their ligands were shown to contribute to MPM aggressiveness and it was suggested that subgroups of MPM patients could benefit from FGFR-targeted inhibitors. In the current investigation, we determined the expression of all four FGFRs (FGFR1-FGFR4) by immunohistochemistry in tissue samples from 94 MPM patients. From 13 of these patients, we were able to establish stable cell lines, which were subjected to FGFR1-4 staining, transcript analysis by quantitative RT-PCR, and treatment with the FGFR inhibitor infigratinib. While FGFR1 and FGFR2 were widely expressed in MPM tissue and cell lines, FGFR3 and FGFR4 showed more restricted expression. FGFR1 and FGFR2 showed no correlation with clinicopathologic data or patient survival, but presence of FGFR3 in 42% and of FGFR4 in 7% of patients correlated with shorter overall survival. Immunostaining in cell lines was more homogenous than in the corresponding tissue samples. Neither transcript nor protein expression of FGFR1-4 correlated with response to infigratinib treatment in MPM cell lines. We conclude that FGFR3 and FGFR4, but not FGFR1 or FGFR2, have prognostic significance in MPM and that FGFR expression is not suffcient to predict FGFR inhibitor response in MPM cell lines.
Keywords: malignant pleural mesothelioma, fibroblast growth factor receptors, azbestos, immunotherapy, chemotherapy, genomic analysis, infigratinib
Published in DiRROS: 07.10.2020; Views: 12145; Downloads: 1032
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264. Priporočila za obravnavo bolnikov s pljučnim rakomMartina Vrankar, Nina Boc, Izidor Kern, Aleš Rozman, Karmen Stanič, Tomaž Štupnik, Mojca Unk, Maja Ebert Moltara, Vesna Zadnik, Katja Adamič, Jernej Benedik, Marko Bitenc, Jasna But-Hadžić, Anton Crnjac, Eva Ćirić, Tanja Čufer, Goran Gačevski, Marta Globočnik Kukovica, Kristina Gornik-Kramberger, Maja Ivanetič Pantar, Staša Jelerčič, Veronika Kloboves-Prevodnik, Mile Kovačević, Luka Ležaič, Mateja Marc-Malovrh, Katja Mohorčič, Bogdan Vidmar, Dušanka Vidovič, Gregor Vlačić, Ana Lina Vodušek, Rok Zbačnik, Ivana Žagar, 2020, professional article Keywords: pljučni rak, priporočila
Published in DiRROS: 22.09.2020; Views: 1917; Downloads: 722
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265. Advanced sensor-based maintenance in real-world exemplary casesMichele Albano, Luis Lino Ferreira, Giovanni Di Orio, Pedro Maló, Godfried Webers, Erkki Jantunen, Iosu Gabilondo, Mikel Viguera, Gregor Papa, 2020, original scientific article Published in DiRROS: 10.09.2020; Views: 1262; Downloads: 650
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266. In-line detection of monoclonal antibodies in the effluent of protein A chromatography with QCM sensorMatic Kisovec, Gregor Anderluh, Marjetka Podobnik, Simon Caserman, 2020, original scientific article Keywords: quartz crystal microbalance, mAb, in-line sensor, protein A, continuous multi-column affinity chromatography
Published in DiRROS: 01.09.2020; Views: 1563; Downloads: 1082
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268. Analiza uspešnosti prodaje gozdnih lesnih sortimentov v gozdarski zadrugi lastnikov gozdov Pohorje - KozjakGregor Černač, Špela Pezdevšek Malovrh, 2020, original scientific article Abstract: V prispevku je na primeru Gozdarske zadruge lastnikov gozdov Pohorje - Kozjak (zadruga) analizirana prodaja gozdnih lesnih sortimentov (GLS) za obdobje 2013%2017. S pomočjo obračunov prodaje GLS smo pridobili podatke o količini in cenah GLS, o prodajalcih GLS ter trgu. Za analizo uspešnosti prodaje GLS smo zadružne cene primerjali s povprečnimi slovenskimi cenami. S pomočjo anketnega vprašalnika smo pridobili podatke o zadovoljstvu članov zadruge z odkupnimi cenami ter samim delovanjem zadruge. Zadruga je večino lesa odkupila od nečlanov zadruge ter ga v veliki meri prodala v sosednjo Avstrijo. Odkupna cena za GLS je v zadrugi za 18,3 % višja od povprečne slovenske. Člani zadruge so v povprečju zadovoljni s cenami za odkupljene GLS, a se kljub temu 37,5 % anketiranih odloča za prodajo tudi drugim odkupovalcem, kar dolgoročno pomeni problem. Na podlagi rezultatov zaključimo, da se je zadružni model poslovnega povezovanja lastnikov gozdov izkazal kot uspešen, zato je nujno, da začne država prek gozdne politike intenzivneje pospeševati in finančno podpirati tovrstne modele poslovnega povezovanja.
Keywords: zasebni gozdovi, poslovno povezovanje, lastništvo gozdov, gozdarske zadruge, trg lesa
Published in DiRROS: 20.08.2020; Views: 5967; Downloads: 1720
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269. Razstava citatov na Slovenskih dnevih sanitarnega inženistva 2018 z mednarodno udeležbo, Ljubljana, 17.-19. oktober 2018Aleš Krulec, Rok FINK, Andrej Ovca, Andreja KUKEC, Mojca JEVŠNIK, Željko LINŠAK, Marija POLJAK, Gregor JEREB, exhibition Keywords: sanitarno inženirstvo, sanitarni inženirji, slovenski dnevi sanitarnega inženirstva, 2018, razstava, mestni muzej ljubljana
Published in DiRROS: 18.08.2020; Views: 2196; Downloads: 907
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