1. Rituximab affects the prognosis of patients with nonHodgkin's lymphomasBarbara Jezeršek Novaković, Marjeta Vovk, Simona Borštnar, Radka Tomšič, 2004, original scientific article Abstract: Backround. Rituximab - the most widely used monoclonal antibody in the B cell lymphoid malignancies has been applied successfully in the treatment of relapsed and refractory indolent CD20 positive B cell lymphomas and more recently, also in the treatment of aggressive lymphomas in combination with standard chemotherapy. Albeit the chemo-immunotherapy has a wide range of potential applications, there are still several issues that have to be resolved: (1) the optimal scheduling of antibody-chemotherapy combinations, (2) the most active of these combinations, as well as (3) the predictors of response to rituximab. Patients and methods. To facilitate addressing the first two questions, we performed an analysis in 25 patients with different histological types of CD20 positive nonHodgkin's lymphomas (10 aggressive and 15 indolent). Seventeen patients were treated with chemo-immunotherapy for a relapse, and just in 8 patients rituximab was added to first line chemotherapy. Most of the responders received the CHOP regimen, but also otherregimens (FC, BVCPP) were effective in combination with rituximab. Results. The overall response rate was 76%, with 68% complete remissions. The median response duration has not been reached yet. The response was markedly better in the group of previously untreated patients, where the overall response rate reached 100%, with 7 patients in complete and 1 patient in partial remission. Most of the treatment failures occurred in heavily pretreated patients with aggressive lymphomas. No serious adverse effects wereobserved. Conclusion The chemo-immunotherapy improves the treatment outcomes in patients with untreated and relapsed CD20 positive nonHodgkin's lymphomas in comparison to chemotherapy alone. The combined treatment is the most effective when used as soon as possible (preferably as the first line treatment). (Abstract truncated at 2000 characters). Published in DiRROS: 07.02.2024; Views: 394; Downloads: 104 Full text (4,61 MB) |
2. Smernice za obravnavo bolnikov z malignimi limfomiMarta Dremelj, Snježana Frković-Grazio, Monika Jagodic, Janez Jančar, Barbara Jezeršek Novaković, Tanja Južnič Šetina, Veronika Kloboves-Prevodnik, Radka Tomšič, Marjeta Vovk, Lorna Zadravec-Zaletel, 2008, dictionary, encyclopaedia, lexicon, manual, atlas, map Published in DiRROS: 27.05.2020; Views: 1948; Downloads: 553 Full text (304,48 KB) |
3. Smernice za obravnavo bolnikov z malignimi limfomiBarbara Jezeršek Novaković, Marta Dremelj, Gorana Gašljević, Monika Jagodic, Janez Jančar, Tanja Južnič Šetina, Veronika Kloboves-Prevodnik, Gregor Kos, Radka Tomšič, Marjeta Vovk, Lorna Zadravec-Zaletel, 2010, dictionary, encyclopaedia, lexicon, manual, atlas, map Published in DiRROS: 27.05.2020; Views: 1997; Downloads: 617 Full text (312,50 KB) |
4. Smernice za obravnavo bolnikov z malignimi limfomiBarbara Jezeršek Novaković, Marta Dremelj, Gorana Gašljević, Monika Jagodic, Janez Jančar, Tanja Južnič Šetina, Veronika Kloboves-Prevodnik, Gregor Kos, Radka Tomšič, Marjeta Vovk, Lorna Zadravec-Zaletel, 2011, dictionary, encyclopaedia, lexicon, manual, atlas, map Published in DiRROS: 27.05.2020; Views: 2000; Downloads: 552 Full text (222,07 KB) |
5. Smernice za obravnavo bolnikov z malignimi limfomiBarbara Jezeršek Novaković, Gorana Gašljević, Monika Jagodic, Janez Jančar, Tanja Južnič Šetina, Veronika Kloboves-Prevodnik, Gregor Kos, Uroš Smrdel, Radka Tomšič, Marjeta Vovk, Lorna Zadravec-Zaletel, 2012, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: maligni limfomi Published in DiRROS: 27.05.2020; Views: 2269; Downloads: 618 Full text (324,98 KB) |
6. Smernice za obravnavo bolnikov z malignimi limfomiBarbara Jezeršek Novaković, Gorana Gašljević, Monika Jagodic, Janez Jančar, Tanja Južnič Šetina, Veronika Kloboves-Prevodnik, Gregor Kos, Uroš Smrdel, Radka Tomšič, Ana Lina Vodušek, Marjeta Vovk, Lorna Zadravec-Zaletel, 2013, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: maligni limfomi Published in DiRROS: 27.05.2020; Views: 2056; Downloads: 629 Full text (233,24 KB) |
7. Smernice za obravnavo bolnikov z malignimi limfomiBarbara Jezeršek Novaković, Gorana Gašljević, Monika Jagodic, Janez Jančar, Tanja Južnič Šetina, Veronika Kloboves-Prevodnik, Gregor Kos, Marija Skoblar Vidmar, Uroš Smrdel, Radka Tomšič, Marjeta Vovk, Lorna Zadravec-Zaletel, 2014, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: maligni limfomi, smernice, novotvorbe Published in DiRROS: 27.05.2020; Views: 2030; Downloads: 622 Full text (888,65 KB) |
8. Smernice za obravnavo bolnikov z malignimi limfomiMarta Dremelj, Gorana Gašljević, Monika Jagodic, Janez Jančar, Barbara Jezeršek Novaković, Tanja Južnič Šetina, Veronika Kloboves-Prevodnik, Radka Tomšič, Marjeta Vovk, Lorna Zadravec-Zaletel, 2009, dictionary, encyclopaedia, lexicon, manual, atlas, map Published in DiRROS: 27.05.2020; Views: 2264; Downloads: 610 Full text (116,21 KB) |
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10. Maligni limfomi v področju glave in vratuRadka Tomšič, 1995, published scientific conference contribution Keywords: onkologija, rak (medicina), limfni sistem, maligni limfomi, glava, vrat, Hodgkinova bolezen, diagnoza Published in DiRROS: 17.09.2019; Views: 2146; Downloads: 591 Full text (77,51 KB) |