1931. Psychosocial coping strategies in cancer patientsLilijana Šprah, Mojca Šoštarič, 2004, review article Abstract: Background. The aim of this review is to present common psychosocial problems in cancer patients and their possible coping strategies. Cancer patients are occupied with many psychosocial problems, which are only partially related to their health state and medical treatments. They are faced with a high social pressure, based on prejudices and stereotypes of this illness. The review presents the process of confrontation with the cancer diagnosis and of managing the psychological consequences of cancer. The effects of specific coping styles, psychosocial interventions and a social support on initiation, progression and recurrence of cancer are also described. Conclusions. Althoughsome recent meta-analysis could not provide scientific evidence for the association befween coping strategies and the cancer initiation, the progression or the recurrence (neither have studies rejected the thesis of association), the therapeutic window for the psychosocial intervention is still wide and shows an important effect on the quality of lives of many cancer patients. Published in DiRROS: 07.02.2024; Views: 327; Downloads: 91
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1932. Rituximab affects the prognosis of patients with nonHodgkin's lymphomasBarbara Jezeršek Novaković, Marjeta Vovk, Simona Borštnar, Radka Tomšič, 2004, original scientific article Abstract: Backround. Rituximab - the most widely used monoclonal antibody in the B cell lymphoid malignancies has been applied successfully in the treatment of relapsed and refractory indolent CD20 positive B cell lymphomas and more recently, also in the treatment of aggressive lymphomas in combination with standard chemotherapy. Albeit the chemo-immunotherapy has a wide range of potential applications, there are still several issues that have to be resolved: (1) the optimal scheduling of antibody-chemotherapy combinations, (2) the most active of these combinations, as well as (3) the predictors of response to rituximab. Patients and methods. To facilitate addressing the first two questions, we performed an analysis in 25 patients with different histological types of CD20 positive nonHodgkin's lymphomas (10 aggressive and 15 indolent). Seventeen patients were treated with chemo-immunotherapy for a relapse, and just in 8 patients rituximab was added to first line chemotherapy. Most of the responders received the CHOP regimen, but also otherregimens (FC, BVCPP) were effective in combination with rituximab. Results. The overall response rate was 76%, with 68% complete remissions. The median response duration has not been reached yet. The response was markedly better in the group of previously untreated patients, where the overall response rate reached 100%, with 7 patients in complete and 1 patient in partial remission. Most of the treatment failures occurred in heavily pretreated patients with aggressive lymphomas. No serious adverse effects wereobserved. Conclusion The chemo-immunotherapy improves the treatment outcomes in patients with untreated and relapsed CD20 positive nonHodgkin's lymphomas in comparison to chemotherapy alone. The combined treatment is the most effective when used as soon as possible (preferably as the first line treatment). (Abstract truncated at 2000 characters). Published in DiRROS: 07.02.2024; Views: 418; Downloads: 109
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1933. A web-application that extends functionality of medical device for tumor treatment by means of electrochemotherapyIvan Pavlović, Peter Kramar, Selma Čorović, David Cukjati, Damijan Miklavčič, 2004, original scientific article Abstract: Electrochemotherapy (ECT) is a novel method for efficient tumor treatment in clinical environment. It combines local drug delivery and application of shorthigh voltage pulses, which permeabilize the plasma membrane by electroporation. Drug can enter only the cells with permeabilzed membrane. Recently, medical device CliniporatorTM for controlled electroporation was developed. Here, we present a web-application that extends the functionality of this medical device. The aim of the application is to collect, store and toallow the analysis of every ECT application using this medical device. The application helps transferring data collected by devčce during the electroporation process to the central database, and enables filling of medical records through the web forms. The application is based on technologies ASP, HTML, Flash, JavaScript, XML and others. The application main advantages are easy and rapid data access, scalability and independence of client computer operating system as well as easy application debugging and upgrading. Keywords: neoplasms- drug therapy, drug delivery systems, elektroporation instrumentation Published in DiRROS: 07.02.2024; Views: 453; Downloads: 110
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1934. Breast cancer and breast health awareness as an evolving health promotion conceptAndrej Plesničar, Viljem Kovač, Božo Kralj, 2004, original scientific article Abstract: Background. Breast cancer is the most frequent malignant disease in the majority of developed countries. In the last few years the introduction of mammography screening programmes has resulted in an improved survival of breast cancer patients. However, the incidence of the disease in these countries is still on the increase. Present focus on secondary breast cancer prevention activities, consisting of early detection and treatment, cannot ensure a decrease of breast cancer incidence. Improved breast health awarenesscould therefore represent a part of specific health promotion activities aimed at decreasing the incidence of breast cancer. Conclusions. Indeveloped countries breast cancer is a significant health care issue. Secondary breast cancer prevention activities should therefore be complementedby specific health promotion activities in order to reduce its incidence in the future. Primary breast cancer prevention would include healthpromotion activities aimed at enhancement of the individual as well as collective breast health awareness. Properly enlightened members of the influential population groups could attain appropriate changes in the fields of legislation, taxation, customs and commercial regulations that would enablewomen to control their own breast health. Published in DiRROS: 07.02.2024; Views: 541; Downloads: 87
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1935. A calcified cervical intervertebral disc in child and a thoracic disc calcification in an adult with posterior herniation-radiographic, computed tomography and magnetic resonance imaging findingsVladimir Jevtič, 2004, professional article Abstract: Izhodišča. Kalcifikacije nukleusa pulposusa pri otroku so sorazmerno redek, vendar dobro znan klinični sindrom, ki se običajno pojavlja na vratni hrbtenici. Natančen vzrok še vedno ni znan. Kalcifikacije medvretenčne ploščice odraslega so večinoma posledica degeneracije in se pojavIjajo v višini spodnje prsne in zgornje ledvene hrbtenice. Pri obeh entitetah lahko nastane resna komplikacija, posteriorna hernijacija kalcificiranega diskusa. Prikaz primera. Prikazana sta dva primera kalcificirane medvretenčne ploščice,prvi pri 7-letnem otroku v višini C7-T1 ter drugi pri 45-letni ženskiv višini T11-T12, oba z razsežno dorzalno hernijacijo. V prvem primeru je dosežena remisija s konservativnom zdravljenjem. Na podlagi analize radiografskih, računalniškotomografskih ter magnetnoresonančnih (MRI) spremembsmo ugotovili podobnosti in razlike med obema entitetama. Zaključki. Masivna dorzalna hernijacija kalcificiranega nukleusa pulposusa pri otroku je uspešno zdravljena konzervativno. Izginotje kliničnih znakov je sledilo hitri resorpciji kalcificirane diskus hernije. Pri odraslem po konzervativnem zdravljenju ni prišlo do resorpcije kalcificirane diskus hernije in kliničnih znakov izboljšanja. Z MRI je možen zgodnejši prikaz kalcifikacij. Tudi razširitev prizadetih medvretenčnih ploščic pri otroku je boljše prikazana z MRI. Razširitev kalcificiranih medvretenčnih ploščic podpira teorijo zvišanegaintradiskalnega pritiska kot vzroka rupture anulusa fibrozusa in posledične hernijacije nukleusa pulposusa. Published in DiRROS: 07.02.2024; Views: 351; Downloads: 82
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1936. Annular pancreas causing extrahepatic biliary obstructionMateja Ogulin, Breda Jamar, 2004, professional article Abstract: Izhodišča. Anularni pankreas, redka prirojena anomalija, je trak pankreatičnega tkiva, ki obkroža dvanajstnik ali izvenjetrni žolčni vod. Prikazujemo primer anularnega pankreasa, ki je povzročil izvenjetrno zaporo odtoka žolča. Prikaz primera. 46-letna ženska je prišla v urgentno ambulanto zaradi nenadnih bolečin v trebuhu, bruhanja in zlatenice. V zadnjih šestih letih je občasno opazila rumenkasto obarvanje kože, v zadnjem letu pa je občutila napetost v zgornjem delu trebuha, predvsem po mastnih obrokih. Zaključki. Dve ultrazvočni preiskavi, prva pred šestimi meseci, sta pokazali razširitev glavnega izvenjetrnega voda in jetrnih žolčnih izvodil. Vzrok za razširitev je ostal nejasen, tudi po endoskopski ultrazvočni preiskavi. Pri operaciji so našli skoraj popolno zaporo izvenjetrenega žolčnega voda, ki jo je povzročal traček pankreatičnega tkiva. Published in DiRROS: 07.02.2024; Views: 419; Downloads: 65
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1937. Demonstration of evolution of hemispherical spondysclerosis by contrast enhanced Gd-DTPA magnetic resonance imagingVladimir Jevtič, Natalija Majcen, 2004, original scientific article Abstract: Izhodišča. Namen študije je bil ugotoviti vrednost slikovne magnetne resonance(MRI) s paramagnetnim kontrastnim sredstvom Gd-DTPA v prikazu napredovanja hemisferične spondiloskleroze (HSS). Bolniki in metode. Pri 18 bolnikih s kronično bolečino v križu in tipičnimi radiografskimi znaki HSS smoopravili Gd-DTPA MRI lumbalne hrbtenice. Primerjali smo morfološke spremembe in spremembe intenzitete signala z radiografskimi znaki HSS. Rezultati. Na podlagi MRI smo primere razdelili v tri skupine. V prvi skupini je bilo radiografsko področje osteoskleroze hipointenzivno na T1-poudarjenih spin-eho slikah, hiperintenzivno na T2-poudarjenih slikah in je kazalo difuznonabiranje paramagnetnega kontrastnega sredstva. Opisane spremembe so bile združljive s kostnim edemom in hiperemijo. V drugi skupini so bili robovivretenc na vseh slikovnih sekvencah hiperintenzivni, obdani s hipointenzivno cono in se v njih ni nabiralo kontrastno sredstvo. Opisano je izražalo kombinacijo maščevja in kostne skleroze. Pri preostalih bolnikih so MRI znaki predstavljali kombinacijo sprememb vidnih v prvi in drugi skupini. Zaključki. Gd-DTPA MRI kaže zapletene histološke spremembe v teku napredovanjaHSS. Spremljanje značilnih MRI znakov ima lahko klinični pomen prisledenju bolezni. Published in DiRROS: 07.02.2024; Views: 410; Downloads: 89
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1938. Mechanisms of premature fracture in modular neck stems made of CoCrMo/Ti6Al4V and Ti6Al4V/Ti6Al4V alloyDrago Dolinar, Miro Gorenšek, Klemen Avsec, Barbara Šetina, Matej Hočevar, Matjaž Godec, Borut Žužek, Mojca Debeljak, Monika Jenko, John T. Grant, Boštjan Kocjančič, 2023, original scientific article Abstract: In this paper, we present the mechanisms of premature fracture of modular neck stems in two case studies: (I) when the neck and stem are both made of the same Ti6Al4V alloy, and (II) when the neck and stem are made from two different alloys, CoCrMo and Ti6Al4V alloy. Our study integrates two orthopedic patients who have undergone primary uncemented THA for usual indications in two orthopedic centers (Community Health Centre and University Medical Centre). Both centers are part of the national public health care system. Both surgeries were performed by two skilled orthopedic surgeons with more than 10 years of experience in THA. The survivorship of the modular neck of cast CoCrMo alloy was 24 months. The survivorship of the modular neck from Ti6Al4V alloy was 84 months. Multivariate analyses were performed to assess the differences in the fretting, corrosion, and fatigue of the two prematurely failed modular neck stems: stereo light microscopy (SLM), scanning electron microscopy (SEM), X-ray energy-dispersive spectroscopy (EDS), and electron backscatter diffraction (EBSD). Patient demographic information, including sex, age, body mass index, survivorship of implants, and reason for the revision, was collected from medical records. We found that fretting and fatigue occurred on both neck-stem retrievals due to additional galvanic corrosion, but the CoCrMo/Ti6Al4V alloy system suffered more corrosion due to additional galvanic corrosion and fractured earlier than the Ti6Al4V/Ti6Al4V metal alloy system. Both metallic alloy systems used in this application are known to be highly corrosion-resistant, but the bio-tribo-corrosion processes need to be understood in detail and characterized so that appropriate improvements in design and materials can be made. Keywords: total hip arthroplasty, modular neck, Ti6Al4V alloy, CoCrMo alloy, corrosion Published in DiRROS: 07.02.2024; Views: 455; Downloads: 249
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1939. Grain size distribution of DP 600 steel using single-pass asymmetrical wedge testUrška Klančnik, Peter Fajfar, Jan Foder, Heinz Palkowski, Jaka Burja, Grega Klančnik, 2023, original scientific article Keywords: wedge test, hot-rolling, grain size distribution, dual-phase steel Published in DiRROS: 07.02.2024; Views: 456; Downloads: 187
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1940. Thermal fatigue degradation progress in SiMo ductile cast iron under oxidation conditionsMilan Terčelj, Jaka Burja, Goran Kugler, Primož Mrvar, 2023, original scientific article Keywords: metallurgical engineering, exhaust manifolds, cast irons, casting, microscopic characterization and microanalysis, thermal fatigue, material defect, microstructural control Published in DiRROS: 07.02.2024; Views: 480; Downloads: 283
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