101. Onkološka obravnava difuznih gliomov odraslega tipaMiha Toplak, 2022, published scientific conference contribution Abstract: Sedanja WHO klasifikacija tumorjev še nadalje integrira molekularno-genetske značilnosti tumorjev.
Difuzni gliomi odraslega tipa so heterogena skupina tumorjev z različno prognozo in različnimi odzivi na zdravljenje, obravnava po operaciji je odvisna od značilnosti tumorja, dejavnikov tveganja in stanja zmogljivosti bolnika. Pri večini bolnikov s tumorji gradusa 3 in 4 po maksimalni varni resekciji v dobrem stanju zmogljivosti prihaja v poštev kombinirano zdravljenje z obsevanjem in kemoterapijo. Pri tumorjih nizkega gradusa je po kirurški obravnavi eventuelno dodatno zdravljenje individualizirano.
Keywords: možganski tumorji, centralno živčevje, radioterapija
Published in DiRROS: 16.12.2022; Views: 570; Downloads: 124
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103. Oligometastatski rakIvica Ratoša, Karmen Stanič, Tanja Ovčariček, Ajra Šečerov Ermenc, Janka Čarman, Blaž Grošelj, Staša Jelerčič, Peter Korošec, Manja Šešek, Marko Kokalj, Gaber Plavc, Miha Oražem, Helena Barbara Zobec Logar, 2022, review article Abstract: Oligometastatska bolezen (OMB) predstavlja vmesno stanje med lokalno napredovalo boleznijo in obsežnejšo metastatsko boleznijo. Zaenkrat ne poznamo specifičnih biomarkerjev, ki bi nam pomagali opredeliti bolnike z majhnim bremenom bolezni, zato diagnoza OMB temelji na slikovni diagnostiki. V zadnjih letih narašča zanimanje za optimizacijo zdravljenja OMB predvsem zaradi obetavnih rezultatov dodatka lokalnega k obstoječemu sistemskemu zdravljenju. S takšnim načinom zdravljenja se je prvič pokazala možnost doseganja dolgotrajnih zazdravitev ali redko celo ozdravitev teh bolnikov. Razlikovanje posameznih vrst OMB in njihovo enotno poimenovanje je pomembno zlasti v kliničnih raziskavah, saj nam omogoča medsebojno primerjavo rezultatov različnih raziskav.
Keywords: klasifikacija, oligometastatska bolezen, sistemsko zdravljenje, onkologija
Published in DiRROS: 06.12.2022; Views: 611; Downloads: 170
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105. Controlled growth of ZnO nanoparticles using ethanolic root extract of Japanese knotweed : photocatalytic and antimicrobial propertiesMiha Ravbar, Ajda Kunčič, Lev Matoh, Sonja Smole Možina, Martin Šala, Andraž Šuligoj, 2022, original scientific article Abstract: Synthesis of zinc oxide (ZnO) nanoparticles (NPs) was mediated by plant extracts to assist in the reduction of zinc atoms during the synthesis and act as a capping agent during annealing.The preparation used ethanolic extracts from the roots of Japanese knotweed (Fallopia japonica). Two major outcomes could be made. (i)A synergistic effect of multiple polyphenolic components in the extract is needed to achieve the capping effect of crystallite growth during thermal annealing at 450 °C characterized by an exponential growth factor (n) of 4.4 compared to n = 3 for bare ZnO. (ii) Synergism between the ZnO NPs and plant extracts resulted in superior antimicrobial activity against both Gram-positive bacteria, e.g., Staphylococcus aureus, and Gram-negative bacteria, e.g., Escherichia coli and Campylobacter jejuni. The materials were also tested for their antimicrobial activity against S. aureus under ultraviolet (UV) illumination. Also here, the photocatalyst prepared with plant extracts was found to be superior. The residues of the plant extract molecules on the surface of the catalyst were identified as the main cause of the observed differences, as proved by thermal gravimetry. Such a preparation using ethanolic extract of Fallopia japonica could serve as a more controlled synthesis of ZnO and potentially other metal oxides, with low environmental impact and high abundance in nature.
Published in DiRROS: 21.11.2022; Views: 484; Downloads: 226
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107. Gostota lesa : metode določanja in pomen pri razvoju gozdno lesnega biogospodarstvaDomen Arnič, Miha Humar, Davor Kržišnik, Peter Prislan, Luka Krajnc, 2021, professional article Keywords: Slovenija, gostota lesa, določanje gostote, biogospodarstvo
Published in DiRROS: 12.11.2022; Views: 546; Downloads: 149
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108. Conversion of Organosolv and Kraft lignins into value-added compounds assisted by an acidic deep eutectic solventFilipe Hobi Bordón Sosa, Ana Bjelić, João A. P. Coutinho, Mariana C. Costa, Blaž Likozar, Edita Jasiukaityte, Miha Grilc, Andre M. da Costa Lopes, 2022, original scientific article Published in DiRROS: 28.10.2022; Views: 505; Downloads: 165
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