31. Hodgkinov limfom : vodnik za bolnikeBarbara Jezeršek Novaković, Samo Zver, Metka Zajc, Aleksandra Grbič, Andreja Cirila Škufca Smrdel, Eda Vrtačnik-Bokal, Vesna Šalamun, Nina Kovačević, Lorna Zadravec-Zaletel, Matej Pečovnik, 2022, not set Keywords: rak (medicina), krvotvorne matične celice, transplantacija, psihološka pomoč, plodnost, hormonsko nadomestno zdravljenje Published in DiRROS: 24.07.2023; Views: 448; Downloads: 104 Full text (1,02 MB) |
32. Organoidi glioblastoma razkrivajo odpornost na standardno terapijoBernarda Majc, Anamarija Habič, Marta Malavolta, Aleksander Sadikov, Andrej Porčnik, Jernej Mlakar, Tamara Lah Turnšek, Barbara Breznik, Metka Novak, 2023, published scientific conference contribution abstract Keywords: glioblastom, organoidi, standardna terapija, model ex vivo, biologija raka Published in DiRROS: 16.06.2023; Views: 441; Downloads: 162 Full text (345,36 KB) This document has many files! More... |
33. The effects of large-scale forest disturbances on hydrology : an overview with special emphasis on karst aquifer systemsUrša Vilhar, Janez Kermavnar, Erika Kozamernik, Metka Petrič, Nataša Ravbar, 2022, original scientific article Abstract: Large-scale forest disturbances (LSFD) are an essential component of forest ecosystem dynamics. The effects of rapid loss of forest cover and other changes in forest ecosystems are inextricably linked to hydrologic processes such as evapotranspiration, soil and recharge processes. Among all hydrogeological systems, karst aquifers are important because of their exceptionally rich and unique biodiversity, biomass, and groundwater resources. At the same time, they are characterized by specific hydrological processes that make them highly vulnerable to environmental changes. Therefore, this study paid special attention to the effects of LSFD on karst hydrology. Using the PRISMA checklist, a thorough literature review of studies published between 2001 and 2020 was compiled into a comprehensive matrix dataset. In addition, an initial assessment of the global and regional distribution of forests on carbonate rocks was made based on publicly available geodatabases of forests and karst aquifers. The compiled information provides the first global overview of hydrological processes affected by LSFD, and identifies important knowledge gaps and future research challenges. The matrix dataset contained 117 full-text articles with a total of 160 case studies. Most publications were from 2011 to 2017, with more than half of the studies at the plot level and more than one-third at the catchment level. Studies on the effects of fires and pest and diseases infestations predominated. However, no articles were found on the effects of ice storms on hydrology in general or on the effects of pest and disease infestations on hydrology in karst areas. Of the 45.6 M km2 of forested land worldwide, 6.3 M km2 or 13.9% of all forests are underlain by carbonate rocks. Carbonate rocks cover about 15% of the land surface, which means that 31.3% of the world's karst aquifers are covered by forest. 29% of all case studies were conducted in karst areas, which is a high proportion compared to the proportion of forests in karst areas. However, these studies are unevenly distributed geographically. Most studies were conducted at the plot level, and only 21% of studies focused on natural LSFD, so forest management and land use change studies predominated. Although studies on the effects of LSFD on evapotranspiration processes between vegetation, air and soil are fairly well represented, infiltration and recharge processes in karst areas remain poorly understood and knowledge is lacking, particularly on groundwater flow and related hydrological processes. Regional studies and impacts on groundwater resources are also insufficient. The results indicate an urgent need for an integrated holistic interdisciplinary approach and a comprehensive understanding of the individual influencing factors, which would allow more accurate modelling of hydrological processes in forested karst aquifers. Keywords: natural disasters, climatic changes, evapotranspiration, hydrology, karst aquifers Published in DiRROS: 19.05.2023; Views: 528; Downloads: 269 Full text (16,50 MB) This document has many files! More... |
34. First report of Erysiphe corylacearum on Corylus avellana and C. colurna in SloveniaJanja Zajc, Mojca Rot, David Snoj, Metka Žerjav, Hans-Josef Schroers, Barbara Piškur, Nikica Ogris, Ana Brglez, 2023, other scientific articles Keywords: common hazel, Turkish hazel, powdery mildew Published in DiRROS: 28.02.2023; Views: 600; Downloads: 245 Full text (258,92 KB) This document has many files! More... |
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36. Plants play a crucial role in the development of soil fungal communities in the remediated substrate after EDTA washing of metal-contaminated soilsIrena Maček, Sara Pintarič, Nataša Šibanc, Tatjana Rajniš, Damjana Kastelec, Domen Leštan, Marjetka Suhadolc, 2022, original scientific article Abstract: In this study, we investigated the importance of plant cover for secondary succession and soil fungal community development in remediated substrates after EDTA washing of metal-contaminated soils. The abundance of the total fungal community, determined by ITS fungal marker genes (Internal Transcribed Spacer region), and root colonisation by arbuscular mycorrhizal (AM) fungi were monitored in two types of soil material (calcareous and acidic) sown with perennial ryegrass (Lolium perenne L.) and without plant cover (bulk soil). Four months after the start of the experiment, the abundance of ITS genes in the soil clearly showed that the presence of plants was the main factor affecting the total fungal community, which increased in the rhizosphere soil in most treatments, while it remained at a low level in the bulk soil (without plants). Interestingly, the addition of environmental inoculum, i.e., rhizosphere soil from a semi-natural meadow, did not have a positive effect on the abundance of the total fungal community. While fungal ITS genes were detected in soils at the end of the first growing season, arbuscular mycorrhizal (AM) structures were scarce in Lolium roots in all treatments throughout the first season. However, in the second season, more than a year after the start of the experiment, AM fungal colonisation was detected in Lolium roots in virtually all treatments, with the frequency of colonised root length ranging from 30% to >75% in some treatments, the latter also in remediated soil. This study demonstrates the importance of plants and rhizosphere in the development and secondary succession of fungal communities in soil, which has important implications for the revitalisation of remediated soils and regenerative agriculture. Keywords: heavy metals, arbuscular mycorrhiza, remediation, revitalisation, secondary succession, biodiversity, qPCR, toxic metals pollution Published in DiRROS: 19.09.2022; Views: 694; Downloads: 291 Full text (1,18 MB) This document has many files! More... |
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38. Organoidi glioblastoma kot model za preučevanje odpornosti na terapijoAnamarija Habič, Bernarda Majc, Andrej Porčnik, Roman Bošnjak, Boštjan Markelc, Maja Čemažar, Tamara Lah Turnšek, Barbara Breznik, Metka Novak, 2022, published scientific conference contribution abstract Keywords: glioblastom, organoidi, odpornost, možganski rak, možganski tumor, onkologija Published in DiRROS: 16.06.2022; Views: 593; Downloads: 241 Full text (80,32 KB) |
39. Odpornost glioblastoma na radioterapijo : vpliv rakavih matičnih celic in mikroo[ko]lja tumorjaBarbara Breznik, Bernarda Majc, Anamarija Habič, Urška Ušeničnik, Andrej Porčnik, Roman Bošnjak, Jernej Mlakar, Marija Skoblar Vidmar, Tanja Jesenko, Maja Čemažar, Tamara Lah Turnšek, Metka Novak, 2022, published scientific conference contribution (invited lecture) Abstract: Glioblastom je najpogostejši možganski tumor pri odraslih z zelo slabo prognozo preživetja bolnikov. Ta je posledica odpornosti glioblastoma na standardno zdravljenje, ki vključuje radioterapijo in kemoterapijo. Z namenom načrtovanja učinkovitejših pristopov zdravljenja preučujemo biološke mehanizme odpornosti glioblastoma na radioterapijo s poudarkom na mikrookolju tumorja in rakavih matičnih celicah. V predkliničnih raziskavah uporabljamo napredne in personalizirane celične modele, ki posnemajo mikrookolje tumorja v bolnikih in z večjo natančnostjo napovedo odziv bolnika na zdravljenje. Hkrati so takšni modeli pomembni za testiranje novih pristopov za zdravljenje kot je imunoterapija. Keywords: glioblastom, mikrookolje, organoidi, možganski rak, možganski tumor, onkologija Published in DiRROS: 16.06.2022; Views: 680; Downloads: 208 Full text (89,78 KB) |
40. Napotki za premagovanje neželenih učinkov sistemskega zdravljenja raka : kaj morate vedeti?Simona Borštnar, Boštjan Šeruga, Marjana Bernot, Marika Horvat, Barbara Jezeršek Novaković, Denis Mlakar-Mastnak, Janja Ocvirk, Samo Rožman, Monika Sonc, Snežana Umičević, Metka Zajc, Branko Zakotnik, 2021, not set Keywords: onkologija, bolniki, nasveti Published in DiRROS: 04.01.2022; Views: 964; Downloads: 336 Full text (4,87 MB) |