231. Predlogi za izboljšanje razmer na področju upravljanja vodnih virovBrigita Jamnik, Mitja Janža, Joerg Prestor, Aleš Smrekar, Urša Vilhar, Branka Bračič-Železnik, Mateja Breg Valjavec, 2012, final research report Keywords: hidrologija, upravljanje vodnih virov, razmere Published in DiRROS: 12.07.2017; Views: 2786; Downloads: 739 Full text (44,82 MB) |
232. Temeljna načela dobre kmetijske prakse varstva rastlin in varne rabe fitofarmacevtskih sredstevGregor Urek, Mateja Bolčič Tavčar, Renata Fras, Viktor Jejčič, Matejka Per, Jolanda Persolja, Lucija Šarc, Meta Urbančič Zemljič, Metka Žerjav, 2013, professional monograph Keywords: integrirano varstvo rastlin, bolezni, škodljivci, zaščita rastlin, zakonodaja, naprave, postopki, varstvo okolja, varnost pri delu Published in DiRROS: 11.07.2017; Views: 5257; Downloads: 1020 Link to full text |
233. Dedni rak dojk in/ali jajčnikov : ambulanta za onkološko genetsko svetovanjeMateja Krajc, Srdjan Novaković, Janez Žgajnar, Ana Blatnik, Erik Škof, Alenka Vrečar, Natalija Klopčič, Amela Duratović Konjević, 2016, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: genetsko svetovanje, rak dojke, rak jajčnikov, dedni rak Published in DiRROS: 14.07.2016; Views: 5611; Downloads: 837 Full text (874,57 KB) |
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237. Postulates for validating TLR4 agonistsMateja Manček Keber, Roman Jerala, 2015, review article Abstract: TLRs play a central role in the innate immune response, recognizing a variety of molecular
structures characteristic of pathogens. Although TLR4, together with its co-receptor
myeloid differentiation-2 (MD-2), recognize bacterial LPS and therefore Gram-negative
bacterial infections, it also plays a key role in many other pathophysiological processes,
including sterile inflammation and viral infection. Specifically, numerous endogenous
agonists of TLR4 of notably diverse nature, ranging from proteins to metal ions, have
been reported. Direct activation of a single receptor by such a range of molecular signals
is very difficult to explain from a structural and mechanistic point of view. It is likely
that only a subset of these directly activate the TLR4–MD-2 complex. We propose three
postulates aimed at distinguishing the direct agonists of TLR4 from indirect activators.
These postulates are as follows: (i) that the agonist requires the TLR4/MD-2 receptor complex;
(ii) that agonist formed synthetically or in situ must activate the receptor complex
in order to eliminate artifacts of contamination by other agonists; and (iii) that a specific
molecular interaction between the agonist and TLR4/MD-2 must be identified. The same
type of postulates can be applied to pattern recognition receptors in general. Keywords: TLR4 agonists, molecular mechanism, ligand recognition Published in DiRROS: 26.01.2015; Views: 5007; Downloads: 486 Link to file |