571. Cancer chemopreventionAmr Amin, Metka Filipič, Su S. Chen, Regine Schneider-Stock, 2012, other scientific articles Abstract: Cancers are characterized by the dysregulation of cell signaling pathways at multiple steps. Most current anticancer therapies however involve the modulation of a single target. The lack of safety and high cost of monotargeted therapies have encouraged alternative approaches. Both natural compounds, extracted from plants or animals, and synthetic compounds, derived from natural prototype structures, are now being used as cancer therapeutics and as chemopreventive compounds. Published in DiRROS: 07.08.2024; Views: 249; Downloads: 164 Full text (45,58 KB) This document has many files! More... |
572. The ocean sampling day consortiumAnna Kopf, Valentina Turk, Tinkara Tinta, 2015, other scientific articles Abstract: Ocean Sampling Day was initiated by the EU-funded Micro B3 (Marine Microbial Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine microbial biodiversity and function of the world’s oceans. It is a simultaneous global mega-sequencing campaign aiming to generate the largest standardized microbial data set in a single day. This will be achievable only through the coordinated efforts of an Ocean Sampling Day Consortium, supportive partnerships and networks between sites. This commentary outlines the establishment, function and aims of the Consortium and describes our vision for a sustainable study of marine microbial communities and their embedded functional traits.
Published in DiRROS: 07.08.2024; Views: 220; Downloads: 185 Full text (430,12 KB) This document has many files! More... |
573. Draft genome sequences of Dickeya sp. isolates B16 (NIB Z 2098) and S1 (NIB Z 2099) causing soft rot of Phalaenopsis orchidsŠpela Alič, Tina Mikuletič, Pablo Llop, Nataša Toplak, Simon Koren, Maja Ravnikar, Tanja Dreo, 2015, other scientific articles Abstract: The genus Dickeya contains bacteria causing soft rot of economically important crops and ornamental plants. Here, we report the draft genome sequences of two Dickeya sp. isolates from rotted leaves of Phalaenopsis orchids.
Keywords: bacteria, plant diseases Published in DiRROS: 07.08.2024; Views: 290; Downloads: 124 Full text (161,12 KB) This document has many files! More... |
574. Range expansion of alien nudibranch Melibe viridis (Kelaart, 1858) in the northern Adriatic SeaLovrenc Lipej, Borut Mavrič, 2017, other scientific articles Abstract: The alien nudibranch Melibe viridis (Kelaart, 1858) was recorded in the waters of Slovenia (Gulf of Trieste, northern Adriatic Sea). A specimen was photographed and fi lmed on rocky hard bottom of the Natural Monument Cape Madona in October 2016. This is the fi rst record of this large sized nudibranch for Slovenia and for the Gulf of Trieste, as well, and a new one among otherwise rare records on this species in the Adriatic Sea. Keywords: Slovenia, non indigenous species, Adriatic Sea Published in DiRROS: 07.08.2024; Views: 248; Downloads: 226 Full text (1,60 MB) This document has many files! More... |
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576. First record of the bryozoan Tricellaria inopinata (dʼHondt & Occhipinti Ambrogi, 1985) from the Slovenian seaAna Fortič, Borut Mavrič, 2018, other scientific articles Abstract: In this paper we present the first record of Tricellaria inopinata d’Hondt & Occhipinti Ambrogi, 1985 for the Slovenian coastal sea. The colonies of this bryozoan were found attached to the mussel shells in the sight of Sečovlje, Strunjan and Debeli rtič mussel cultures from April to October 2018 and in Valdoltra harbour in November 2018. After the introduction into the Lagoon of Venice in the 1980s and its rapid spread throughout the lagoon in the following years, the species was regarded as an invasive taxon for that area and it is highly expected to colonize the whole Northern Adriatic region. The status of T. inopinata and its ecological impact has yet to be determined for the Slovenian coastal sea. Keywords: alien species, Gulf of Trieste, Adriatic Sea, mussel aquaculture Published in DiRROS: 07.08.2024; Views: 248; Downloads: 176 Full text (1,10 MB) This document has many files! More... |
577. Occurrence of ribbon fish (Trachipterus trachypterus) In Slovenian waters (Northern Adriatic Sea)Lovrenc Lipej, Domen Trkov, Borut Mavrič, 2018, other scientific articles Abstract: On 6th May 2018 a juvenile specimen of ribbon fish (Trachipterus trachypterus) was collected in shallow waters in Izola (Slovenia, northern Adriatic Sea). It measured 403 mm in total length and weighed 37.1 g. In stomach, fragments of seagrasses, pollen cones of pine, petals of terrestrial plant, fragments of terrestrial grass and beetles were found among food remains. The possible causes of this finding in Slovenian waters could be attributed to the ingression of southern Adriatic waters in its northern part. The specimen studied in this paper is the fifth record of this species in the Slovenian part of the Adriatic Sea. The cooperation between ichthyologists and fishermen proved to be crucial for the detection of the ribbon fish and other rare and less-known fish species, as well. Keywords: ribbon fish, occurrence (biology), diet, Adriatic Sea Published in DiRROS: 07.08.2024; Views: 246; Downloads: 181 Full text (1,26 MB) This document has many files! More... |
578. On the rare and less known shamefaced crab Calappa granulata (Brachyura, Calappidae) in the Northern Adriatic SeaNicola Bettoso, Marin Kirinčić, Borut Mavrič, Lovrenc Lipej, 2018, other scientific articles Abstract: On 1st August 2016 and 23th July 2017 two specimens of the shamefaced crab Calappa granulata (Linnaeus, 1758) were caught in the northernmost area of the Adriatic Sea and represent the second and third offi cial record, respectively. More recently the records of this commercial species start to be no more unusual in this northern region. It is too early to express any reliable comment regarding whether or not this species established a breeding population in this area, however we could consider its northward extension as another consequence of global warming. Keywords: shamefaced crab, northern Adriatic, global warming Published in DiRROS: 07.08.2024; Views: 250; Downloads: 164 Full text (1,18 MB) This document has many files! More... |
579. CXCR4 antagonists as stem cell mobilizers and therapy sensitizers for acute myeloid leukemia and glioblastoma?Vashendriya V. V. Hira, Cornelis J. F. van Noorden, Remco J. Molenaar, 2020, other scientific articles Abstract: Glioblastoma is the most aggressive and malignant primary brain tumor in adults and has a poor patient survival of only 20 months after diagnosis. This poor patient survival is at least partly caused by glioblastoma stem cells (GSCs), which are slowly-dividing and therefore therapy-resistant. GSCs are localized in protective hypoxic peri-arteriolar niches where these aforementioned stemness properties are maintained. We previously showed that hypoxic peri-arteriolar GSC niches in human glioblastoma are functionally similar to hypoxic peri-arteriolar hematopoietic stem cell (HSC) niches in human bone marrow. GSCs and HSCs express the receptor C-X-C receptor type 4 (CXCR4), which binds to the chemoattractant stromal-derived factor-1α (SDF-1α), which is highly expressed in GSC niches in glioblastoma and HSC niches in bone marrow. This receptor–ligand interaction retains the GSCs/HSCs in their niches and thereby maintains their slowly-dividing state. In acute myeloid leukemia (AML), leukemic cells use the SDF-1α–CXCR4 interaction to migrate to HSC niches and become slowly-dividing and therapy-resistant leukemic stem cells (LSCs). In this communication, we aim to elucidate how disruption of the SDF-1α–CXCR4 interaction using the FDA-approved CXCR4 inhibitor plerixafor (AMD3100) may be used to force slowly-dividing cancer stem cells out of their niches in glioblastoma and AML. Ultimately, this strategy aims to induce GSC and LSC differentiation and their sensitization to therapy.
Keywords: glioblastoma, glioblastoma stem cells, niches, acute myeloid leukemia, hematopoietic stem cells, bone marrow, C-X-C receptor type 4, stromal-derived factor-1 ▫$[alpha]$▫, plerixafor Published in DiRROS: 06.08.2024; Views: 262; Downloads: 283 Full text (1,51 MB) This document has many files! More... |
580. The role of natural science collections in the biomonitoring of environmental contaminants in apex predators in support of the EU’s zero pollution ambitionPaola Movalli, Jan Koschorreck, Gabriele Treu, Jaroslav Slobodnik, Nikiforos Alygizakis, Andreas Androulakakis, Alexander Badry, Emanuel Baltag, Fausto Barbagli, Kevin Bauer, Koos Biesmeijer, Al Vrezec, 2021, other scientific articles Abstract: The chemical industry is the leading sector in the EU in terms of added value. However, contaminants pose a major threat and significant costs to the environment and human health. While EU legislation and international conventions aim to reduce this threat, regulators struggle to assess and manage chemical risks, given the vast number of substances involved and the lack of data on exposure and hazards. The European Green Deal sets a ‘zero pollution ambition for a toxic free environment’ by 2050 and the EU Chemicals Strategy calls for increased monitoring of chemicals in the environment. Monitoring of contaminants in biota can, inter alia: provide regulators with early warning of bioaccumulation problems with chemicals of emerging concern; trigger risk assessment of persistent, bioaccumulative and toxic substances; enable risk assessment of chemical mixtures in biota; enable risk assessment of mixtures; and enable assessment of the effectiveness of risk management measures and of chemicals regulations overall. A number of these purposes are to be addressed under the recently launched European Partnership for Risk Assessment of Chemicals (PARC). Apex predators are of particular value to biomonitoring. Securing sufficient data at European scale implies large-scale, long-term monitoring and a steady supply of large numbers of fresh apex predator tissue samples from across Europe. Natural science collections are very well-placed to supply these. Pan-European monitoring requires effective coordination among field organisations, collections and analytical laboratories for the flow of required specimens, processing and storage of specimens and tissue samples, contaminant analyses delivering pan-European data sets, and provision of specimen and population contextual data. Collections are well-placed to coordinate this. The COST Action European Raptor Biomonitoring Facility provides a well-developed model showing how this can work, integrating a European Raptor Biomonitoring Scheme, Specimen Bank and Sampling Programme. Simultaneously, the EU-funded LIFE APEX has demonstrated a range of regulatory applications using cutting-edge analytical techniques. PARC plans to make best use of such sampling and biomonitoring programmes. Collections are poised to play a critical role in supporting PARC objectives and thereby contribute to delivery of the EU’s zero-pollution ambition. Keywords: zero pollution, biomonitoring, chemicals of emerging concern, Apex predator, raptor, marine mammal, otter Published in DiRROS: 06.08.2024; Views: 272; Downloads: 183 Full text (858,56 KB) This document has many files! More... |