1871. Tubakia spp., Didymella macrostoma and Apiognomonia errabunda causing leaf spot and anthracnose of Quercus robur in the Mura-Drava-Danube Biosphere ReserveMilica Zlatković, Marcus Sallmannshofer, Silvio Schueler, Thomas L. Cech, Milutin Djilas, Gernot Hoch, Katharina Lapin, Nikica Ogris, Barbara Piškur, Katharina Schwanda, Srđan Stojnić, Marjana Westergren, Saša Orlović, 2024, original scientific article Abstract: The Mura-Drava-Danube transboundary UNESCO Biosphere Reserve represents one of the best-preserved wetlands in Europe. The Reserve’s riparian forests play a significant role in ecosystem functioning and pedunculate oak (Quercus robur) is one of the keystone species of these forests. In recent years, pedunculate oak trees in the Reserve displayed symptoms of necrotic lesions on their leaves. The lesions varied in size, from small, circular to irregular reddish brown to grayish spots to larger necrotic areas that resembled leaf anthracnose and extended along the leaf nerves. In 2021, symptomatic leaves were collected in three countries of the Reserve, i.e. Austria, Slovenia, and Serbia to identify the causative agents of these diseases. Fungal cultures were obtained from symptoms and identified using morphology and multilocus phylogenetic analyses of the ITS rDNA, partial LSU rDNA, tef 1-α, BT2, CAL, ACT, and RPB2 genes. The fungi were identified as Tubakia dryina, Tubakia sp. (Tubakia dryinoides sensu lato), Didymella macrostoma, and Apiognomonia errabunda. Pathogenicity tests done by inoculating the leaves of one-year old pedunculate oak plants revealed that the isolated fungi caused symptoms as those seen in the forest. To our knowledge, this study represents the first report of D. macrostoma as the cause of pedunculate oak leaf spot disease in Serbia and worldwide. It is also the first finding of Tubakia leaf spot disease of pedunculate oak caused by T. dryina in Austria and Serbia. Moreover, Tubakia sp. was proven to be another causative agent of Tubakia leaf spot disease. Additionally, oak anthracnose caused by A. errabunda was found for the first time on pedunculate oak leaves in Austria and Slovenia. During the past decade, pedunculate oak trees have been facing increasing threats from multiple abiotic and biotic factors which has resulted in decline and absence of natural regeneration of these trees. The results of this study add to the understanding of the contributing factors to the decline of pedunculate oak in riparian forests and are important for the development of management strategies to counteract this decline.
Keywords: Mura-Drava-Danube Biosphere Reserve, riparian forests, Tubakia leaf spot, Didymella macrostoma, oak anthracnose, pedunculate oak, leaf spot diseases
Published in DiRROS: 23.04.2024; Views: 473; Downloads: 244
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1872. NutriGreen image dataset : a collection of annotated nutrition, organic, and vegan food productsJan Drole, Igor Pravst, Tome Eftimov, Barbara Koroušić-Seljak, 2024, original scientific article Abstract: In this research, we introduce the NutriGreen dataset, which is a collection of images representing branded food products aimed for training segmentation models for detecting various labels on food packaging. Each image in the dataset comes with three distinct labels: one indicating its nutritional quality using the Nutri-Score, another denoting whether it is vegan or vegetarian origin with the V-label, and a third displaying the EU organic certification (BIO) logo.
Published in DiRROS: 23.04.2024; Views: 496; Downloads: 184
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1874. Mesenteric ischemia after capecitabine treatment in rectal cancer and resultant short bowel syndrome is not an absolute contraindication for radical oncological treatmentAna Perpar, Erik Brecelj, Nada Rotovnik-Kozjek, Franc Anderluh, Irena Oblak, Marija Skoblar Vidmar, Vaneja Velenik, 2015, other scientific articles Abstract: Thrombotic events, arterial or venous in origin, still remain a source of substantial morbidity and mortality in cancer patients. The propensity for their development in oncology patients is partially a consequence of the disease itself and partially a result of our attempts to treat it. One of the rarest and deadliest thromboembolic complications is arterial mesenteric ischemia. The high mortality rate is caused by its rarity and by its non-specific clinical presentation, both of which make early diagnosis and treatment difficult. Hence, most diagnoses and treatments occur late in the course of the disease. The issue survivors of arterial mesenteric ischemia may face is short bowel syndrome, which has become a chronic condition after the introduction of parenteral nutrition at home. We present a 73-year-old rectal cancer patient who developed acute arterial mesenteric thrombosis at the beginning of the pre-operative radiochemotherapy. Almost the entire length of his small intestine, except for the proximal 50 cm of it, and the ascending colon had to be resected. After multiorgan failure his condition improved, and he was able to successfully complete radical treatment (preoperative radiotherapy and surgery) for the rectal carcinoma, despite developing short bowel syndrome (SBS) and being dependent upon home-based parenteral nutrition to fully cover his nutritional needs. Mesenteric ischemia and resultant short bowel syndrome are not absolute contraindications for radical oncological treatment since such patients can still achieve long-term remission.
Keywords: acute mesenteric ischemia, capecitabine, multiorgan failure, rectal cancer, short bowel syndrome
Published in DiRROS: 23.04.2024; Views: 453; Downloads: 126
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1875. Preoperative treatment with radiochemotherapy for locally advanced gastroesophageal junction cancer and unresectable locally advanced gastric cancerIvica Ratoša, Irena Oblak, Franc Anderluh, Vaneja Velenik, Jasna But-Hadžić, Ajra Šečerov Ermenc, Ana Jeromen, 2015, original scientific article Abstract: To purpose of the study was to analyze the results of preoperative radiochemotherapy in patients with unresectable gastric or locoregionally advanced gastroesophageal junction (GEJ) cancer treated at a single institution. Between 1/2004 and 6/2012, 90 patients with locoregionally advanced GEJ or unresectable gastric cancer were treated with preoperative radiochemotherapy at the Institute of Oncology Ljubljana. Planned treatment schedule consisted of induction chemotherapy with 5-fluorouracil and cisplatin, followed by concomitant radiochemotherapy four weeks later. Three-dimensional conformal external beam radiotherapy was delivered by dual energy (6 and 15 MV) linear accelerator in 25 daily fractions of 1.8 Gy in 5 weeks with two additional cycles of chemotherapy repeated every 28 days. Surgery was performed 4-6 weeks after completing radiochemotherapy. Following the surgery, multidisciplinary advisory team reassessed patients for the need of adjuvant chemotherapy. The primary endpoints were histopathological R0 resection rate and pathological response rate. The secondary endpoints were toxicity of preoperative radiochemotherapy and survival. Treatment with preoperative radiochemotherapy was completed according to the protocol in 84 of 90 patients (93.3%). Twenty patients (22.2%) did not undergo the surgery because of the disease progression, serious comorbidity, poor performance status or still unresectable tumour. In 13 patients (14.4%) only exploration was performed because the tumour was assessed as unresectable or diffuse peritoneal carcinomatosis was established. Fifty-seven patients (63.4%) underwent surgery with the aim of complete removal of the tumour. Radical resection was achieved in 50 (55.6%) patients and the remaining seven (7.8%) patients underwent non-radical surgery (R1 in five and R2 in two patients). In this group of patients (n = 57), pathological complete response of tumour was achieved in five patients (5.6% of all treated patients or 8.8% of all operated patients). Down-staging was recorded in 49 patients (86%), in one patient (1.8%) the stage after radiochemotherapy was unchanged while in seven patients (12.3%) the pathological stage was higher than clinical, mainly due to higher pN stage. No death was recorded during preoperative radiochemotherapy. Most grade 3 and 4 toxicities were due to vomiting, nausea and bone marrow suppression (granulocytopenia). Twentysix (45.6%) patients died due to GEJ or gastric carcinoma, one died because of septic shock following the surgery and a reason for two deaths was unknown. Twenty-eight patients (49.1%) were disease free at the time of analysis, while 29 patients (50.9%) developed the recurrence, mostly as distant metastases. At two years, locoregional control, diseasefree survival, disease-specific survival and overall survival were 82.9%, 43.9%, 56.9% and 53.9%, respectively. Preoperative radiochemotherapy was feasible in our group of patients and had acceptable toxicity. Majority of patients achieved down-staging, allowing greater proportion of radical resections (R0), which are essential for patientsʼ cure.
Keywords: neoadjuvant radiochemotherapy, perioperative chemotherapy, chemotherapy, adenocarcinoma, carcinoma, surgery
Published in DiRROS: 23.04.2024; Views: 451; Downloads: 170
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1876. Endobronchial ultrasound elastography strain ratio for mediastinal lymph node diagnosisAleš Rozman, Mateja Marc-Malovrh, Katja Adamič, Tjaša Šubic, Viljem Kovač, Matjaž Fležar, 2015, original scientific article Keywords: cancer staging, elastography, endobronchial ultrasound, lung cancer, needle biopsy
Published in DiRROS: 23.04.2024; Views: 467; Downloads: 245
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1878. Release of growth factors after mechanical and chemical pleurodesis for treatment of malignant pleural effusion : a randomized control studyAljaž Hojski, Maja Leitgeb, Anton Crnjac, 2015, original scientific article Abstract: Growth factors are key inducers of fibrosis but can also mediate inflammatory responses resulting in increasing pleural effusion and acute respiratory distress syndrome. The primary aim of the study was to analyse growth factors release after performing chemical and mechanical pleurodesis in the first 48 hours at the patients with malignant pleural effusion. The secondary endpoints were to evaluate the effectiveness of the both pleurodeses, symptoms release and the quality of life of patients after the treatment. Patients and methods. A prospective randomized study included 36 consecutive female patients with breast carcinoma and malignant pleural effusion in an intention-to-treat analysis. We treated 18 patients by means of thoracoscopic mechanical pleurodesis and 18 patients by chemical pleurodesis with talcum applied over a chest tube. We gathered the pleural fluid and serum samples in the following 48 hours under a dedicated protocol and tested them for growth factors levels. A quality of life and visual analogue pain score surveys were also performed. Results. Median measured serum vascular endothelial growth factor (VEGF) level after chemical pleurodesis was 930.68 pg/ml (95% CI: 388.22-4656.65) and after mechanical pleurodesis 808.54 pg/ml. (95% CI: 463.20-1235.13) (p = 0.103). Median pleural levels of transforming growth factor (TGF) ß1 were higher after performing mechanical pleurodesis (4814.00 pg/ml [95% CI: 2726.51-7292.94]) when compared to those after performing chemical pleurodesis (1976.50 pg/ml [95% CI: 1659.82-5136.26]) (p = 0.078). We observed similar results for fibroblast growth factor (FGF) ß; the serum level was higher after mechanical pleurodesis (30.45 pg/ml [95% CI: 20.40-59.42]), compared to those after chemical pleurodesis (13.39 pg/ml [95% CI: 5.04-74.60]) (p = 0.076). Mechanical pleurodesis was equally effective as chemical pleurodesis in terms of hospital stay, pleural effusion re-accumulation, requiring of additional thoracentesis, median overall survival, but, it shortened the mean thoracic drainage duration (p = 0.030) and resulted in a higher symptoms release and in a better quality of life (p = 0.047). Conclusions. We recorded an increase in serum VEGF levels after chemical pleurodesis, however on the contrary, an increase in the pleural fluid level of TGF%1 and FGF%] after mechanical pleurodesis with respect to compared group. Although the differences did not reach statistical significance, VEGF, TGFß1 and FGFß remain the most interesting parameters for future research. Considering the mechanisms of growth factors action, we conclude that in our study group mechanical pleurodesis might be more efficient in terms of growth factors release, thoracic drainage duration and resulted in a higher symptoms release and in a better quality of life than chemical pleurodesis.
Keywords: malignant pleural effusion, pleurodesis, growth factors, quality of life
Published in DiRROS: 23.04.2024; Views: 513; Downloads: 399
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1880. Towards deploying highly quantized neural networks on FPGA using chiselJure Vreča, Anton Biasizzo, 2023, published scientific conference contribution Abstract: We present chisel4ml, a Chisel-based tool that generates hardware for highly quantized neural networks described in QKeras. Such networks typically use parameters with bitwidths less than 8 bits and may have pruned connections. Chisel4ml can generate the highly quantized neural network as a single combinational circuit with pipeline registers in between the different layers. It supports heterogeneous quantization where each layer can have a different precision. The full parallelization enables very low-latency and high throughput inference, that are required for certain tasks. We illustrate this on the triggering system for the CERN Large Hadron Collider, which filters out events of interest and sends them on for further processing. We compare our tool against hls4ml, a high-level synthesis based approach for deploying similar neural networks. Chisel4ml is still under development. However, it already achieves comparable results to hls4ml for some neural network architectures. Chisel4ml is available on https://github.com/cs-jsi/chisel4ml.
Keywords: neural networks, QKeras, Chisel4ml
Published in DiRROS: 23.04.2024; Views: 365; Downloads: 237
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