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2. Long term results of radiotherapy in vulvar cancer patients in Slovenia between 1997-2004Helena Barbara Zobec Logar, 2017, original scientific article Abstract: The aim of this retrospective single institution study was to analyse long term results of vulvar cancer treatment with conventional 2D radiotherapy in Slovenia between years 1997%2004. Patients and methods. Fifty-six patients, median age 74.4 years +/- 9.7 years, mainly stage T2 or T3, were included in the study. All patients were treated with radiotherapy, which was combined with surgery (group A), used as the primary treatment (group B) or at the time of relapse (group C). Chemotherapy was added in some patients. Histology, grade, lymph node status, details of surgery, radiation dose to the primary tumour, inguinofemoral and pelvic area as well as local control (LC) and survival were evaluated. Results. Overall survival (OS), disease specific survival (DSS) and LC rates at 10-years for all patients were as follows: 22.7%, 34.5% and 41.1%, respectively. The best 10-years results of the treatment were achieved in the primary operated patients treated with adjuvant radiotherapy +/-chemotherapy (OS 31.9%, DSS 40.6% and LC 47.6%). Positive lymph nodes had a strong influence on LC. In case of positive nodes LC decreased by 60% (p = 0.03) and survival decreased by 50% (p = 0.2). There was a trend to a better LC with higher doses % 54.0 Gy (p = 0.05). Conclusions. The best treatment option for patients with advanced vulvar cancer is combined treatment with surgery and radiotherapy +/- chemotherapy, if feasible. Radiotherapy with the dose of % 54.0 Gy should be considered to achieve better LC if positive adverse factors are present.
Keywords: vulvar cancer, radiotherapy, surgery, survival
Published in DiRROS: 31.05.2024; Views: 84; Downloads: 53
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5. Obsevanje ginekoloških tumorjevBarbara Šegedin, Helena Barbara Zobec Logar, Manja Šešek, Ana Perpar, Blaž Grošelj, Miha Oražem, 2023, professional monograph Keywords: teleterapija, brahiterapija, prehrana, kemoterapija, stranski učinki
Published in DiRROS: 22.11.2023; Views: 424; Downloads: 115
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7. Zapleti zdravljenja z obsevanjemHelena Barbara Zobec Logar, 2023, published scientific conference contribution Abstract: V ospredju neželenih učinkov pri obsevanju medenice zaradi raka prostate so gastrointestinalni in genitourinarni zapleti. Pri teleradioterapiji so izrazitejši na danki in črevesju, pri brahiterapiji pa so izrazitejše obstruktivne težave z uriniranjem. Motnje v erektilni funkciji so največkrat posledica sočasnega hormonskega zdravljenja in izhodiščnega stanja pred obsevanjem. Večina neželenih učinkov je blagih, resni pozni zapleti stopnje G3 ali več so prisotni v manj kot 5 %.
Keywords: rak prostate, onkološko zdravljenje, obsevanje
Published in DiRROS: 03.02.2023; Views: 413; Downloads: 101
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10. Oligometastatski rak 2022 : [strokovno srečanje2022, proceedings of professional or unreviewed scientific conference contributions Abstract: Oligometastatski rak predstavlja v zdravljenju onkoloških bolnikov posebno entiteto. Čeprav gre v osnovi za metastatsko bolezen, pa novejši pristopi in novi načini zdravljenja omogočajo izboljšanje kontrole bolezni in preživetja. Čedalje agresivnejše zdravljenje s sistemsko terapijo, imunoterapijo, tarčnimi zdravili, obsevanjem, operativnim zdravljenjem in številnimi drugimi pristopi, to bolezen postavlja v povsem novo luč in verjetno ni daleč čas, ko bomo rekli, da je oligometastaski rak ozdravljiv.
Published in DiRROS: 13.12.2022; Views: 623; Downloads: 359
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