41. Delavnica Smernice za gospodarjenje z gozdovi na hudourniških območjih v luči nedavnih ujm na Gozdarskem inštitutu SlovenijeUrša Vilhar, Andrej Breznikar, Andreja Gregorič, Gregor Danev, Boris Rantaša, Jaša Saražin, David Štefanič, Jože Papež, 2023, professional article Keywords: gospodarjenje z gozdovi, urejanje hudournikov
Published in DiRROS: 29.02.2024; Views: 263; Downloads: 67
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42. Kompoziti iz skorje: nova gozdarsko-lesarska vrednostna verigaSergej Medved, Grega Vilman, Urban Tajher, Mark Sever, Alan Antonović, 2023, original scientific article Abstract: Skorja je večopravilni (večfunkcijski) material, saj deluje kot zaščita (pred fizikalnimi in mehanskimi poškodbami, pa tudi pred biološko razgradnjo), omogoča transport vode in plinov, občasno pomaga pri fotosintezi in nudi podporo drevesu. Skorje je od 10 % do 20 % celotne mase drevesa, vendar je znaten delež ostane neizkoriščen. Da bi prikazali možnosti rabe skorje za izdelavo različnih kompozitov, smo izdelali in analizirali tri različne kompozite, in sicer lesno-plastični kompozit iz skorje in polietilena, trislojni ploščni kompozit iz skorje, zlepljene z melamin-urea-formaldehidnim lepilom, in enoslojni ploščni kompozit iz vlažnih iveri skorje, zlepljenih s taninskimi lepili.
Keywords: skorja, iveri, lesno plastični kompozit, iverna plošča
Published in DiRROS: 29.02.2024; Views: 288; Downloads: 61
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43. General position polynomialsVesna Iršič, Sandi Klavžar, Gregor Rus, James Tuite, 2024, original scientific article Abstract: A subset of vertices of a graph $G$ is a general position set if no triple of vertices from the set lie on a common shortest path in $G$. In this paper we introduce the general position polynomial as $\sum_{i \geq 0} a_i x^i$, where $a_i$ is the number of distinct general position sets of $G$ with cardinality $i$. The polynomial is considered for several well-known classes of graphs and graph operations. It is shown that the polynomial is not unimodal in general, not even on trees. On the other hand, several classes of graphs, including Kneser graphs $K(n,2)$, with unimodal general position polynomials are presented.
Keywords: general position set, general position number, general position polynomial, unimodality, trees, Cartesian product of graphs, Kneser graphs
Published in DiRROS: 28.02.2024; Views: 196; Downloads: 112
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44. Vpliv temperature in gostote na mehanske lastnosti ekspandiranega polistirena : magistrsko deloJaka Vaupot, 2023, master's thesis Keywords: ekspandiran polistiren, tlačna trdnost, natezna trdnost, temperaturno utrujanje materiala, povišana temperatura, mikrostruktura, dimenzijska stabilnost, magistrsko delo
Published in DiRROS: 27.02.2024; Views: 234; Downloads: 63
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45. Assessment of differential expression of oncogenes in adenocarcinoma of stomach with fluorescent labeling and simultaneous amplification of gene transcriptsUroš Rajčević, Petra Hudler, Gordan Mijovski, Gregor Gorjanc, Georg Hölzl, Stanislav Repše, Robert Juvan, Milena Kovač, Christian G. Huber, Radovan Komel, 2007, original scientific article Abstract: Background. Gastric cancer is one of the leading malignancies with a poor prognosis and low survival rates. Although the mechanisms underlying its development are still unknown, there is a consensus that genetic instability, inactivation of tumor suppressor genes and over-expression of oncogenes are involved in the early and late stages of gastric carcinogenesis. In the present study we wanted to display differential expression of seven oncogenes,namely CCNE1, EGF, ERBB3, FGF4, HRG1, HGFR and TDGF1. Patients and methods. We employed a method based on the multiplex reverse transcription polymerase chain (RT-PCR) method with a fluorescence detection. Results. More than half of patients (74.3%) out of total 74 with gastric adenocarcinoma had over-expressed at least one oncogene, with the exception of FGF4, which was expressed in tumor tissue of less than one third of patients. 56.8% of the patients patients showed over-expression of two or more oncogenes. Conclusions. Patients with precancerous lesions had elevated levels of TDGF1 or cripto-1 (64.9%) and CCNE1 (57.1%), suggesting that they could be used as markers for an early detection of malignant changes in stomach. Finally, the fluorescent multiplex RT-PCR method could be of value for rapid assessment of oncogene mRNA levels in small samples of tumor or precancerous biopsies.
Published in DiRROS: 20.02.2024; Views: 175; Downloads: 47
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47. Quasi-copulas as linear combinations of copulasGregor Dolinar, Bojan Kuzma, Nik Stopar, 2024, original scientific article Abstract: We prove that every quasi-copula can be written as a uniformly converging infinite sum of multiples of copulas. Furthermore, we characterize those quasi-copulas which can be written as a finite sum of multiples of copulas, i.e., that are a linear combination of two copulas. This generalizes a recent result of Fernández-Sánchez, Quesada-Molina, and Úbeda-Flores who considered linear combinations of discrete copulas.
Keywords: quasi-copulas, copulas, linear combination, affine combination, Minkowski norm
Published in DiRROS: 16.02.2024; Views: 217; Downloads: 87
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48. Electrochemotherapy of tumoursGregor Serša, Maja Čemažar, Damijan Miklavčič, Zvonimir Rudolf, 2006, review article Abstract: Electroehemotherapy consists of chemotherapy followed by local application of electrie pulses to the tumour to increase drug delivery into cells. Drug uptake can be inereased by electroporation for only those drugs whose transport through the plasma membrane is impeded. Among many drugs that have been tested so far, only bleomycin and cisplatin found their way from preclinical testing to clinical trials. In vitro studies demonstrated several fold inerease of their cytotoxicity after electroporation of cells. In vivo, electroporation of tumours after local or systemic administration of either ofthe drugs, i.e. electrochemotherapy, proved to be an effective antitumour treatment. In preclinical studies on several tumour models, electrochemotherapy either with bleomycin or cisplatin was elaborated and parameters for effective local tumour control were determined. In veterinary medicine, electrochemotherapy also proved to be effective in the treatment of primary tumours in cats, dogs and horses. In human clinical studies, electrochemotherapy was performed on the patients with progressive disease andaccessible tumour nodules of different malignancies. All clinical studies demonstrated that electrochemotherapy is an effective treatment for local tumour control in cancer patients.
Published in DiRROS: 15.02.2024; Views: 191; Downloads: 47
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49. Schedule-dependency of doxorubicin and vinblastine in EAT tumours in miceMarija Auersperg, Ana Pogačnik, Veronika Kloboves-Prevodnik, Gregor Serša, Maja Čemažar, 2006, original scientific article Abstract: Background. Antitumour schedule-dependency of the doxorubicin and vinblastine combination was explored. Materials and methods. Intraperitoneal Ehrlich ascites tumours (EAT) syngeneic to CBA mice were treated with vinblastine ar doxorubicin alone, or in combined treatment schedules. Results. Combinations of doxorubicin and vinblasfine administered at 48-h, but not at 24-h interval,regardless of the sequence of drugs, significantly reduced the numberof tumour cells in the ascites in corrtparison with all other treatments. In the combined treatment schedules, the predominant morphologicalchanges as well as DNA distribution pattern were dependent on thefirst drug applied. Regardless of the sequence of the drugs, median survival times of animals did not significantly differ between the treatment groups. Conclusions. The effect of combination of vinblastine and doxorubicin is schedule-dependent. The time interval, but not the sequence of drugs seems to be crucial for the observed effect. The data from preclinical studies are important for planning combined treatment schedules in clinical setting.
Published in DiRROS: 15.02.2024; Views: 141; Downloads: 34
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50. Effect of electroporation on radiosensitization with cisplatin in two cell lines with different chemo- and radiosensitivitySimona Kranjc Brezar, Maja Čemažar, Alenka Grošel, Živa Pipan Tkalec, Gregor Serša, 2003, original scientific article Abstract: Aim. Radiosensitization with cisplatin can be enhanced by electroporation of cells and tumours. The aim of this study was to extend our previous studies ontwo carcinoma tumour models with different chemo-and radiosensitivity in order to evaluate whether this treatment is effective also on less chemo-and radiosensitive tumour cells. Materials and methods. This in vitro study was performed on carcinoma SCK and EAT-E cells. The cytotoxicity of three-modalitytreatment consisting of cisplatin, electroporation and irradiation was determined by the clonogenic assay. Results. The radiosensitizing effect of cisplatin on the two cell lines was greatly enhanced by electroporation. By this combined treatment, less chemo and radiosensitive EAT-E cells were rendered as sensitive as more chemo and radiosensitive SCK cells. Conclusion. The enhancement of cisplatin-induced radiosensitization of cells by electroporation could be beneficially used in the treatment of intrinsically less chemo- and radiosensitive tumours.
Published in DiRROS: 06.02.2024; Views: 187; Downloads: 39
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