161. Priporočila za obravnavo bolnikov s pljučnim rakomMartina Vrankar, Nina Boc, Izidor Kern, Aleš Rozman, Karmen Stanič, Tomaž Štupnik, Mojca Unk, Maja Ebert Moltara, Vesna Zadnik, Katja Adamič, Jernej Benedik, Marko Bitenc, Jasna But-Hadžić, Anton Crnjac, Eva Ćirić, Tanja Čufer, Goran Gačevski, Marta Globočnik Kukovica, Kristina Gornik-Kramberger, Maja Ivanetič Pantar, Staša Jelerčič, Veronika Kloboves-Prevodnik, Mile Kovačević, Luka Ležaič, Mateja Marc-Malovrh, Katja Mohorčič, Bogdan Vidmar, Dušanka Vidovič, Gregor Vlačić, Ana Lina Vodušek, Rok Zbačnik, Ivana Žagar, 2020, professional article Keywords: pljučni rak, priporočila Published in DiRROS: 22.09.2020; Views: 2185; Downloads: 821 Full text (1,37 MB) |
162. Correlations between vitreous cytokine levels and inflammatory cells in fibrovascular membranes of patients with proliferative diabetic retinopathyMojca Urbančič, Danijel Petrovič, Aleksandra Milutinović Živin, Peter Korošec, Matjaž Fležar, Mojca Globočnik Petrovič, 2020, original scientific article Abstract: Purpose: The purpose of this study was to investigate the levels of cytokines in the vitreous, and their correlation with the density of inflammatory cells in fibrovascular membranes (FVMs) in patients with proliferative diabetic retinopathy (PDR) to evaluate intraocular inflammatory conditions with regard to disease activity.Methods: Thirty-three patients (33 eyes) with PDR requiring vitreoretinal surgery because of FVMs and tractional detachment were enrolled in the study, and compared with 20 patients (20 eyes) with macular hole (MH; control group). All patients underwent complete ophthalmological examinations before surgery. The activity of the disease was noted in patients with PDR. Samples of vitreous and blood were taken, and cytokine (MCP-1, IL-8, IL-6, VEGF, IL-1%, TNF-%, MIP-1%, MIP-1%, IL-10, and IL-12) levels were measured using cytometric bead array (CBA). Samples of FVMs were analyzed with immunohistochemical methods for the presence of inflammatory cells (CD45+, CD14+, CD3+, CD4+, CD8+, and CD19+ cells), and the numerical areal density was calculated (NA). Spearman%s correlation was used to as-sess the association between variables. The Mann%Whitney test was used to assess the differences between independent groups. The Wilcoxon signed-rank test was used for assessing differences between two related groups. A p value of less than 0.05 was considered statistically significant.Results: Patients with active PDR had statistically significantly higher levels of MCP-1 (p = 0.003), VEGF (p = 0.009), and IL-8 (p = 0.02) in the vitreous in comparison with those with inactive PDR. CD45+, CD14+, CD3+, CD4+, CD8+, and CD19+ cells were identified in FVMs for patients with PDR. Statistically significantly higher numerical areal density of T lymphocytes (CD3+, CD4+, and CD8+) was demonstrated in patients with active PDR in comparison with patients with inactive PDR. Moderate to strong correlations were found between either MCP-1 or IL-8 in the vitreous, and the numerical areal density of cells (CD45+, CD3+, CD4+, and CD8+) in the FVMs, and weaker between either MCP-1 or IL-8 in the vitreous and the numerical areal density of CD14+ cells in the FVMs.Conclusions: The correlation of cytokine (MCP-1 and IL-8) vitreous levels with the density of inflammatory cells in FVMs, and differences in cytokine levels in the vitreous between patients with active and inactive PDR, and between the vitreous and serum in PDR indicate the importance of local intraocular inflammation in patients with PDR. Keywords: diabetic retinopathy, fibrovascular membranes, inflammatory cells Published in DiRROS: 09.09.2020; Views: 1673; Downloads: 828 Full text (784,61 KB) This document has many files! More... |
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164. Razstava citatov na Slovenskih dnevih sanitarnega inženistva 2018 z mednarodno udeležbo, Ljubljana, 17.-19. oktober 2018Aleš Krulec, Rok FINK, Andrej Ovca, Andreja KUKEC, Mojca JEVŠNIK, Željko LINŠAK, Marija POLJAK, Gregor JEREB, exhibition Keywords: sanitarno inženirstvo, sanitarni inženirji, slovenski dnevi sanitarnega inženirstva, 2018, razstava, mestni muzej ljubljana Published in DiRROS: 18.08.2020; Views: 2419; Downloads: 1055 Full text (130,65 MB) |
165. Zdravila za uporabo v paliativni mediciniJožica Červek, Mojca Simončič Godnič, Jernej Benedik, Maja Ebert Moltara, Jasenka Gugić Kevo, Slavica Lahajnar, Petra Tavčar, 2012, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: paliativna medicina, zdravila Published in DiRROS: 10.08.2020; Views: 2155; Downloads: 635 Full text (1,15 MB) |
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167. Pogovor o zdravilu brigatinib : vodnik vašega zdravljenjaMojca Unk, 2020, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: kemoterapija, onkološka zdravila, nedrobnocelični pljučni rak Published in DiRROS: 30.07.2020; Views: 1962; Downloads: 515 Full text (403,71 KB) |
168. Prezgodnje odpadanje listov velikega jesena je povzročila gliva Hymenoscyphus albidus, povzročiteljica jesenovega ožigaNikica Ogris, Tine Hauptman, Mojca Bogovič, 2010, professional article Keywords: veliki jesen, Fraxinus excelsior L., glive, Hymenoscyphus albidus, listi, jesenov ožig, bolezni drevja, gozdovi, varstvo gozdov Published in DiRROS: 29.07.2020; Views: 1719; Downloads: 846 Link to full text This document has many files! More... |
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