1. Long-term survival in glioblastoma : methyl guanine methyl transferase (MGMT) promoter methylation as independent favourable prognostic factorUroš Smrdel, Mara Popović, Matjaž Zwitter, Emanuela Boštjančič, Andrej Zupan, Viljem Kovač, Damjan Glavač, Drago Bokal, Janja Jerebic, 2016, original scientific article Abstract: In spite of significant improvement after multi-modality treatment, prognosis of most patients with glioblastoma remains poor. Standard clinical prognostic factors (age, gender, extent of surgery and performance status) do not clearly predict long-term survival. The aim of this case-control study was to evaluate immuno-histochemical and genetic characteristics of the tumour as additional prognostic factors in glioblastoma. Long-term survivor group were 40 patients with glioblastoma with survival longer than 30 months. Control group were 40 patients with shorter survival and matched to the long-term survivor group according to the clinical prognostic factors. All patients underwent multimodality treatment with surgery, postoperative conformal radiotherapy and temozolomide during and after radiotherapy. Biopsy samples were tested for the methylation of MGMT promoter (with methylation specific polymerase chain reaction), IDH1 (with immunohistochemistry), IDH2, CDKN2A and CDKN2B (with multiplex ligation-dependent probe amplification), and 1p and 19q mutations (with fluorescent in situ hybridization). Methylation of MGMT promoter was found in 95% and in 36% in the long-term survivor and control groups, respectively (p < 0.001). IDH1 R132H mutated patients had a non-significant lower risk of dying from glioblastoma (p= 0.437), in comparison to patients without this mutation. Other mutations were rare, with no significant difference between the two groups. Molecular and genetic testing offers additional prognostic and predictive information for patients with glioblastoma. The most important finding of our analysis is that in the absence of MGMT promoter methylation, longterm survival is very rare. For patients without this mutation, alternative treatments should be explored.
Keywords: glioblastoma, long-term survival, methyl guanine methyl transferase, MGMT, prognostic factor
Published in DiRROS: 30.04.2024; Views: 155; Downloads: 137
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3. Morphological characteristics of young and old murine hematopoietic stem cell niches, as modeled in vitroMojca Justin, Ema Rogac Randl, Veno Kononenko, Matej Hočevar, Damjana Drobne, Primož Rožman, 2023, original scientific article Abstract: The hematopoietic stem cell (HSC) niche undergoes detrimental changes with age. The molecular differences between young and
old niches are well studied and understood; however, young and old niches have not yet been extensively characterized in terms of
morphology. In the present work, a 2D stromal model of young and old HSC niches isolated from bone marrow was investigated
using light and scanning electron microscopy (SEM) to characterize cell density after one, two, or three weeks of culturing, cell
shape, and cell surface morphological features. Our work is aimed at identifying morphological differences between young and
old niche cells that could be used to discriminate between their respective murine HSC niches. The results show several age-
specific morphological characteristics. The old niches differ from the young ones in terms of lower cell proliferating capacity,
increased cell size with a flattened appearance, increased number of adipocytes, and the presence of tunneling nanotubes. In
addition, proliferating cell clusters are present in the young niches but not in the old niches. Together, these characteristics
could be used as a relatively simple and reliable tool to discriminate between young and old murine HSC niches and as a
complementary approach to imaging with specific cellular markers.
Keywords: bone marrow, hematoopetic stem cell niche, aging, adipocytes, scanning electron microscopy
Published in DiRROS: 26.01.2024; Views: 284; Downloads: 131
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4. Construction materials for a sustainable future : proceedings of the 2nd International Conference CoMS 2020/212021, proceedings of peer-reviewed scientific conference contributions (international and foreign conferences) Abstract: Zbornik pokriva številne, predvsem tehnične teme, ki so pomembne za trajnostni razvoj gradbenega sektorja, kot ključnega dejavnika pri doseganju ciljev EU za obvladovanje podnebnih sprememb in za prehod v brezogljično družbo. Vsebinsko naslavlja inovacije v gradbenih materialih in tehnologijah, vključno s komponentami za zdravo in udobno bivanje, ter interakcije med materiali in okoljem. Poleg energetske učinkovitosti stavb je v njem zajeto področje širšega razumevanja trajnostnega načrtovanja, gradnje in vzdrževanja stavb ter monitoring, ocenjevanje in modeliranje stavb. Vključuje pa tudi vsebine, ki se nanašajo na krožno gospodarstvo, kot je recikliranje materialov in komponent ter koncepti sanacij stavb, ter na digitalizacijo in avtomatizacijo področja.
Keywords: trajnostno gradbeništvo, trajnostna gradnja, gradbeni materiali, tehnologije, energetska učinkovitost, zborniki, elektronske knjige
Published in DiRROS: 25.01.2024; Views: 316; Downloads: 107
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8. Construction materials for a sustainable future : proceedings of the 2nd International Conference CoMS 2020/212020, proceedings of peer-reviewed scientific conference contributions (international and foreign conferences) Abstract: Zbornik pokriva številne, predvsem tehnične teme, ki so pomembne za trajnostni razvoj gradbenega sektorja, kot ključnega dejavnika pri doseganju ciljev EU za obvladovanje podnebnih sprememb in za prehod v brezogljično družbo. Vsebinsko naslavlja inovacije v gradbenih materialih in tehnologijah, vključno s komponentami za zdravo in udobno bivanje, ter interakcije med materiali in okoljem. Poleg energetske učinkovitosti stavb je v njem zajeto področje širšega razumevanja trajnostnega načrtovanja, gradnje in vzdrževanja stavb ter monitoring, ocenjevanje in modeliranje stavb. Vključuje pa tudi vsebine, ki se nanašajo na krožno gospodarstvo, kot je recikliranje materialov in komponent ter koncepti sanacij stavb, ter na digitalizacijo in avtomatizacijo področja.
Published in DiRROS: 19.01.2024; Views: 326; Downloads: 81
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9. Znanje, ki pušča sled : sedemdeset let Zavoda za gradbeništvo Slovenije 1949-20192019, professional monograph Abstract: V publikaciji je predstavljen Zavod za gradbeništvo Slovenije, ob 70-letnici. V osmih poglavjih je predstavljeno znanstveno-raziskovalno in strokovno delo. V nadaljevanju sledijo poglavja, ki predstavljajo posamezne zanszveno-raziskovalne laboratorije in strokovne službe.
Keywords: Zavod za gradbeništvo Slovenije, ZAG Ljubljana, gradbeništvo, znanstveno-raziskovalna dejavnost, strokovna dejavnost, laboratoriji, predstavitev, 70 let, sedemdeset let, grajeno okolje, digitalizacija, gradnja, les, krožno gospodarstvo, napredni materiali v gradbeništvu, potresi, stavbe, trajnostna gradnja, bivanje, ekologija, voda, zrak, zemlja
Published in DiRROS: 19.01.2024; Views: 263; Downloads: 205
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10. Knowledge that leaves a mark : seventy years of the Slovenian National Building and Civil Engineering Institute 1949-20192019, professional monograph Abstract: V publikaciji je predstavljen Zavod za gradbeništvo Slovenije ob 70-letnici. V osmih poglavjih je predstavljeno znanstveno-raziskovalno in strokovno delo. V nadaljevanju sledijo poglavja, ki predstavljajo posamezne znanstveno-raziskovalne laboratorije in strokovne službe.
Keywords: Zavod za gradbeništvo Slovenije, ZAG Ljubljana, gradbeništvo, znanstveno-raziskovalna dejavnost, strokovna dejavnost, laboratoriji, predstavitev, 70 let, sedemdeset let, grajeno okolje, digitalizacija, gradnja, les, krožno gospodarstvo, napredni materiali v gradbeništvu, potresi, stavbe, trajnostna gradnja, bivanje, ekologija, voda, zrak, zemlja
Published in DiRROS: 19.01.2024; Views: 268; Downloads: 150
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