1. Total neoadjuvant treatment of locally advanced rectal cancer with high risk factors in SloveniaMojca Tuta, Nina Boc, Erik Brecelj, Mirko Omejc, Franc Anderluh, Ajra Šečerov Ermenc, Ana Jeromen, Irena Oblak, Bojan Krebs, Vaneja Velenik, 2019, original scientific article Keywords: total neoadjuvant treatment, radiochemotherapy, rectal cancer
Published in DiRROS: 05.07.2024; Views: 87; Downloads: 23
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3. Induction chemotherapy, chemoradiotherapy and consolidation chemotherapy in preoperative treatment of rectal cancer : long-term results of phase II OIGIT-01 TrialDanijela Golo, Jasna But-Hadžić, Franc Anderluh, Erik Brecelj, Ibrahim Edhemović, Ana Jeromen, Mirko Omejc, Irena Oblak, Ajra Šečerov Ermenc, Vaneja Velenik, 2018, original scientific article Abstract: The purpose of the study was to improve treatment efficacy for locally advanced rectal cancer (LARC) by shifting half of adjuvant chemotherapy preoperatively to one induction and two consolidation cycles. Patients and methods Between October 2011 and April 2013, 66 patients with LARC were treated with one induction chemotherapy cycle followed by chemoradiotherapy (CRT), two consolidation cycles, surgery and three adjuvant capecitabine cycles. Radiation doses were 50.4 Gy for T2-3 and 54 Gy for T4 tumours in 1.8 Gy daily fraction. The doses of concomitant and neo/adjuvant capecitabine were 825 mg/m2/12h and 1250mg/m2/12h, respectively. The primary endpoint was pathologic complete response (pCR). Results Forty-three (65.1%) patients were treated according to protocol. The compliance rates for induction, consolidation, and adjuvant chemotherapy were 98.5%, 93.8% and 87.3%, respectively. CRT was completed by 65/66 patients, with G % 3 non-hematologic toxicity at 13.6%. The rate of pCR (17.5%) was not increased, but N and the total-down staging rates were 77.7% and 79.3%, respectively. In a median follow-up of 55 months, we recorded one local relapse (LR) (1.6%). The 5-year disease-free survival (DFS) and overall survival (OS) rates were 64.0% (95% CI 63.89%64.11) and 69.5% (95% CI 69.39%69.61), respectively. Conclusions In LARC preoperative treatment intensification with capecitabine before and after radiotherapy is well tolerated, with a high compliance rate and acceptable toxicity. Though it does not improve the local effect, it achieves a high LR rate, DFS, and OS.
Keywords: rectal cancer, neoadjuvant chemotherapy, preoperative chemoradiotherapy
Published in DiRROS: 11.06.2024; Views: 74; Downloads: 49
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4. The influence of the distal resection margin length on local recurrence and long- term survival in patients with rectal cancer after chemoradiotherapy and sphincter- preserving rectal resectionJan Grosek, Vaneja Velenik, Ibrahim Edhemović, Mirko Omejc, 2017, original scientific article Keywords: rectal cancer, distal resection margin, chemoradiotherapy, local recurrence, survival
Published in DiRROS: 31.05.2024; Views: 279; Downloads: 116
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5. Risk based life-cycle planning for flood-resilient critical infrastructureSandra Škarić Palić, I. Stipanovic, E. Ganic, Mirko Kosič, Andrej Anžlin, M. Bacic, M. S. Kovacevic, K. Gavin, 2023, published scientific conference contribution Abstract: The paper presents a risk assessment model, developed in the project oVER-FLOw and further implemented in the project CROSScade, for determining the direct and indirect impacts of flooding hazards. As a consequence of flooding, transport infrastructure and flood protection systems can be significantly damaged and cause cascading effects on other infrastructure. To achieve flood resilient infrastructure, it is necessary to assess the vulnerability of critical assets in the affected area. The model uses novel vulnerability assessment methods for embankments and bridges exposed to different flood hazard scenarios allowing the asset owners to understand risk and performance of their infrastructure. Scarce financial resources are allocated on the critical assets allowing significant cost savings and avoiding the waste of non-renewable resources in strengthening large sections which have sufficient resilience. The consequence analysis is based on an improved quantification model for direct and indirect impacts of different flood hazard scenarios used for risk mapping of the affected area.
Keywords: flooding, risk assessment, critical infrastructure, economic loss
Published in DiRROS: 23.05.2024; Views: 195; Downloads: 152
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6. Outcome of small cell lung cancer (SCLC) patients with brain metastases in a routine clinical settingMirko Lekić, Viljem Kovač, Nadja Triller, Lea Knez, Aleksander Sadikov, Tanja Čufer, 2012, original scientific article Abstract: Background. Small cell lung cancer (SCLC) represents approximately 13 tomediansurvival of SCLC patients treated by specific therapy (chemotherapy andžor radiotherapy) with regard to the 18%months in patients treated with standard chemotherapy and radiotherapy. Inpresence or absence of brain metastases at the time of diagnosis. Patients and methods. All SCLC patients have been treated in a routine clinical practice and followed up at theUniversity Clinic Golnik in Slovenia. In the retrospective study the medical files from 2002 to 2007 were review. All patients with cytological or histological confirmed disease and eligible for specific oncological treatment were included in the study. They have been treated according to the guidelines valid at the time. Chemotherapy and regular followed-up were carried out at the University Clinic Golnik and radiotherapy at the Institute of Oncology Ljubljana. Results. We found 251 patients eligible for the study. The median age of them was 65 years, majoritywere male (67%), smokers or ex-smokers (98%), with performance status 0 to 1 (83%). At the time of diagnosis no metastases were found in 64 patients(25.5%) and metastases outside the brain were presented in 153 (61.0%). Brain metastases, confirmedby a CT scan, were present in 34 patients (13.5%), most of them had also metastases at other localisations. (Abstract truncated at 2000 characters)
Keywords: pljuča, rak (medicina), drobnocelični rak, metastaze, možgani
Published in DiRROS: 22.03.2024; Views: 211; Downloads: 65
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7. Tehnične smernice za ohranjanje in rabo genskih virov : lesnika in drobnica = Malus sylvestris, Pyrus pyrasterMirko Perušek, Gregor Božič, Robert Brus, Hojka Kraigher, 2012, professional article Keywords: genski viri, drevesne vrste, tehnične smernice, lesnika, Malus sylvestris, drobnica, Pyrus pyraster, Slovenija
Published in DiRROS: 20.12.2023; Views: 421; Downloads: 120
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9. Effects of selected printing parameters on the fire properties of 3D-printed neat polylactic acid (PLA) and wood/PLA compositesNataša Knez, Mirko Kariž, Friderik Knez, Nadir Ayrilmis, Manja Kitek Kuzman, 2021, original scientific article Abstract: The effects of selected printing parameters on the fire properties of additively produced composites from neat polylactic acid (PLA) and wood/PLA filaments were investigated. The reaction to fire of the 3D-printed specimens was tested according to the ISO 5660-1 cone calorimeter test method. The results showed that the properties of the specimens when exposed to fire were significantly affected by the incorporation of wood flour into the PLA filament. It was also interesting that PLA specimens had much better reactions to fire than the wood/PLA specimens. Time to ignition was found to be much longer in the 3D-printed PLA specimens. Although the maximal heat release rate was a little higher in the PLA than the wood/PLA specimens, the duration of HRR was longer for the wood/PLA specimens. The initial mass of the specimens was smaller in the wood/PLA composites, but during the radiant heat exposure the mass typically decreased slower than in the PLA specimens.
Keywords: reaction to fire, wood, polylactic acid (PLA), filament, 3D printer, biocomposite
Published in DiRROS: 17.07.2023; Views: 369; Downloads: 224
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10. Flood vulnerability study of a roadway bridge subjected to hydrodynamic actions, local scour and wood debris accumulationMirko Kosič, Andrej Anžlin, Valentina Bau', 2022, original scientific article Abstract: The increased occurrence and intensity of flooding events have represented a real threat to bridge reliability and end-user safety. As flood vulnerability assessment is a valuable tool for enhancing the resilience of bridges to climate change, it is of interest to push the development of such methods. To this end, a computationally efficient methodology to assess the flood vulnerability of a bridge was developed and implemented in a case study. A particular focus was devoted to modelling wood debris loads on the bridge pier, for which two different approaches were implemented. The first is a standards-based approach, whereas the second is based on up-to-date research data. The results indicate that the second approach is less conservative as it leads up to a 40% higher exceedance probability for the considered limit states. The interaction between wood debris loads and local scour was also examined and proved to have a relevant impact on the vulnerability of the bridge. These results highlight the shortcomings of the existing standards in providing accurate results. It is perceived that not only will the new quantitative tool be valuable in ensuring optimal bridge design, but it will also be beneficial for assessing bridge risk mitigation measures.
Keywords: flooding, vulnerability, wood debris, local scour, hydrodynamic load, stochastic approach, bridges, open access
Published in DiRROS: 31.05.2023; Views: 477; Downloads: 246
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