41. Survivin - an inhibitor of apoptosis and a new therapeutic target in cancerJože Pižem, Andrej Cör, 2003, professional article Abstract: Survivin is a unique member of the inhibitor of apoptosis (IAP) protein family. It inhibits apoptosis by interfering with post-mitochondrial events during apoptosis, thus blocking activation of caspases. The expression of survivin is among the most tumour specific of all human genes. It is overexpressed in most human cancers but is not detected in most normal tissues. Some molecular mechanisms of survivin upregulation in cancer have been elucidated, including loss of the wild-type p53. Tumours that overexpresssurvivin generally bear a worse prognosis and are associated with resistance to therapy. Its differential expression in caneer versus normal tissues makes survivin detection a useful tool in cancer diagnostics and a promising therapeutic target. Survivin targeting has resulted in increased spontaneous and induced apoptosis and inhibition of tumourgrowth. Some anticaneer drugs currently introduced into clinical practice might well act byinactivaring survivin.
Published in DiRROS: 06.02.2024; Views: 236; Downloads: 48
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42. Cathepsin L in human meningiomasMiha Trinkaus, Andrej Vranič, Vinko V. Dolenc, Tamara Lah Turnšek, 2003, original scientific article Keywords: meningioma-pathology, cathepsin L, reverse transcriptase, polymerase chain reaction, neoplasm invasiveness
Published in DiRROS: 06.02.2024; Views: 216; Downloads: 54
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43. The impact of Al2O3 particles from grit-blasted Ti6Al7Nb (alloy) implant surfaces on biocompatibility, aseptic loosening, and infectionBoštjan Kocjančič, Klemen Avsec, Barbara Šetina, Darja Feizpour, Matjaž Godec, Veronika Kralj-Iglič, Rok Podlipec, Andrej Cör, Mojca Debeljak, John T. Grant, Monika Jenko, Drago Dolinar, 2023, original scientific article Keywords: Ti6Al7Nb implant alloy cementless hip endoprostheses, roughness, Al2O3 grit blasting, surface and subsurface implant contamination, cytotoxicity, aseptic loosening, infection, osseointegration
Published in DiRROS: 01.02.2024; Views: 253; Downloads: 91
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44. Effects of 5-Gy irradiation on fertility and mating behaviour of Nezara viridula (Heteroptera: Pentatomidae)Alenka Žunič Kosi, Andrej Čokl, Gregor Serša, 2002, original scientific article Abstract: Background. The polyphagous and cosmopolitan species Nezara viridula is one ofthe most important insect pests. The sterile insect technique (SIT) is a pest control strategy that involves sterilising males by exposing them to ionising radiation. Sterile males, released into wild population, mate with females, but eggs are not fertilised and the population gradually declines. Exposing insects to radiation during their growth stage might require lower sterilising dose. The aim of our study was to test whether 5-Gy irradiation of5th instar nymphs significantly affects: (1) moulting and further development of the irradiated nymphs, (2) the male's and female's reproduetivesystem and (3) the mating competitiveness of treated males, with special focus on vibrational communication. Methods: The 5th instar nymphs were irradiated with 5 Gy using X ray generator and monitored daily. Results: The observed effects of irradiation were: prolonged moulting increased mortality during development and during the first day of adult life, decreasedmales to females ratio, decreased fecundity, egg production, proportion of fertile eggs and progeny survival. The reaction of a male to stimulation with the model female calling song was tested. The irradiated and non-irradiated males responded to stimulation with emission of the eourtship song (MCrS). Temporal parameters of MCrS emitted by non-irradiated males differed when compared with those of irradiated ones. Conclusions: The 5-Gy irradiation of 5th instar nymphs did not affect mating behaviour. However since the irradiation during growth stage decreased the fertility and fecundity of emerged adults, this technique, in combination with certain othersuppression teehniques, could be a successful control strategy for management of Nezara viridula. On the other hand observed effects on moulting and further development of the irradiated nymphs could decrease the efficiencyand application of this strategy.
Published in DiRROS: 31.01.2024; Views: 222; Downloads: 47
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45. Environment and breast cancer - the role of xenooestrogens in breast cancerAndrej Plesničar, Branko Družina, Viljem Kovač, Božo Kralj, 2002, original scientific article Abstract: The survival rate of breast cancer patients has not changed much in the last few decades in developed countries. In order to improve the efficacy of breast cancer prevention and treatment, the role of xenooestrogens in the mechanisms of its development has been evaluated. These industrial chemical bear little structural resemblance to each other and bind to the oestrogen receptors of exposed cells and/or trigger oestrogenic responses in laboratory test systems. Exposure to xenooestrogens has been regarded as a risk factor for carcinogenesis and a preventable cause of breast carcinoma. Several epidemiological and experimental studies in in vivo and in vitro conditions of the influence of xenooestrogens on the occurrence of breast cancer have been conducted in the last decades and have shown ambiguous results. No increase of breast carcinoma incidence could be found in women who were exposed to relatively high concentrations of xenooestrogens for extended periods and small quantities of these compounds that are present in the environment probably cannot act as etiological agents for the occurence of this disease. A multi step approach is suggested regarding the sequence of studies and measures that should be taken to further assess the importance of xenooestrogens on breast cancer carcinogenesis.
Keywords: dojka, ksenoestrogeni, novotvorbe
Published in DiRROS: 31.01.2024; Views: 181; Downloads: 45
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47. Kartiranje in vrednotenje ekosistemskih storitev na Jelovici : projekt JeloviZaAnže Japelj, Andreja Ferreira, Andrej Kobler, Anže Martin Pintar, Katja Kavčič Sonnenschein, 2023, final research report Keywords: ekosistemske storitve, vrednotenje, kartiranje, Jelovica, kaskadni model
Published in DiRROS: 26.01.2024; Views: 349; Downloads: 0 |
48. Kartiranje in vrednotenje ekosistemskih storitev na Jelovici : projekt JeloviZaAnže Japelj, Andreja Ferreira, Andrej Kobler, Anže Martin Pintar, Katja Kavčič Sonnenschein, 2023, treatise, preliminary study, study Keywords: ekosistemske storitve, vrednotenje, kartiranje, Jelovica, kaskadni model
Published in DiRROS: 26.01.2024; Views: 316; Downloads: 0 |
49. The relationship between DNA methylation and expression of three different DNA methyltransferases in ovarian cancerAndrej Cör, 2000, original scientific article Abstract: Background. DNA methylation in mammals is required for embryonic development, X chromosome inactivation and imprinting. Previous studies have shown that methylation patterns become abnormal in malignant cells and may contribute to tumorigenesis. The aim of the study was to ascertain the relationship between overall DNA methylation and the expression of DNMT1, DNMT3A and DNMT3B in ovarian cancer samples. Material and methods. DNA digestion with either methylation sensitive HpaII, or methylation insensitive MspI restriction endonuclease and quantitative reverse transcription-PCR methods were used to analyse global methylation levels and expression levels of five ovarian cancerand three normal ovarian tissue samples. Results. All five analysed cancer samples were hypomethylated. The differences of methylation levels between normal ovarian tissue and carcinoma samples were statistically significant (P<0.05). All five cancer samples showed overexpression of DNMT3A and DNMT3B, and only two ovarian tumour samples showed overexpression of DNMT1. There was no correlation between global demethylation and expression levels for the three different DNMTs.Conclusion. Genome wide hypomethylation facilitates tumor development with predisposition of cells to structural and numerical chromosomal aberrations but the paradox of the global hypomethylation observed in cancer cells and the high levels of DNMTs that arepresent in these cells still remain to be resolved.
Published in DiRROS: 25.01.2024; Views: 224; Downloads: 52
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50. Comprehensive permanent remote monitoring system of a multi-span highway bridgeAndrej Anžlin, Uroš Bohinc, Doron Hekič, Maja Kreslin, Jan Kalin, Aleš Žnidarič, 2021, published scientific conference contribution Abstract: As part of the reconstruction of a multi-span viaduct on a Slovenian highway, a permanent remote monitoring system with over 200 sensors was established. Several parameters are monitored on different parts of the viaduct by means of temperature sensors, accelerometers, strain gauges, long-gauge deformation and Fibre Bragg Grating (FBG) sensors. In this way strains, frequencies and temperatures on external prestressed beam cables, carbon fibre rebarsused for the flexural strengthening of a deck overhang, pier caps and prestressed beams are measured and stored into the on-site central data acquisition system. This paper presents architecture of the permanent bridge monitoring system and preliminary results of the measurements.
Keywords: permanent monitoring, structural health monitoring, bridge WIM, sensors, viaduct
Published in DiRROS: 22.01.2024; Views: 357; Downloads: 152
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