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1491 - 1500 / 2000
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Glave za podiranje na strojih za sečnjo
Peter Smolnikar, 2025, professional article

Keywords: gozdarstvo, stroji za sečno
Published in DiRROS: 22.07.2025; Views: 414; Downloads: 164
.pdf Full text (5,20 MB)

1497.
Vodila gozdnemu posestniku za spremljanje kakovosti gradnje gozdne vlake
Jaša Saražin, Gašper Ogrin, Robert Robek, Jan Mihelič, 2025, professional article

Keywords: gozdarstvo, lastniki gozdov, navodila, gozdne vlake
Published in DiRROS: 22.07.2025; Views: 466; Downloads: 166
.pdf Full text (5,20 MB)

1498.
Basophil activation test predicts cetuximab anaphylaxis severity in alpha-gal IgE-positive patients
Peter Kopač, Ana Koren, Urška Bidovec, Mitja Košnik, Luka Dejanović, Tanja Mesti, Primož Strojan, Peter Korošec, Janja Ocvirk, 2024, original scientific article

Abstract: Upon first exposure to cetuximab, hypersensitivity reactions can occur. We aimed to assess the utility of the basophil activation test (BAT) to alpha-gal and cetuximab for predicting severe reactions. We prospectively recruited 38 patients and evaluated sIgE to alpha-gal in all patients before the first application of cetuximab. In all alpha-gal-sensitized patients, we evaluated skin tests to meat extracts, gelatine, and cetuximab and performed BAT with alpha-gal and cetuximab. In 24% (9/38) of patients, sIgE to alpha-gal was >0.10 kUA/L, and 8/9 reacted to the cetuximab. Basophil activation tests with alpha-gal were positive in all sensitized patients and were higher in those with severe reactions (18.3% in grade 4 [n = 4] vs. 1.8% in grade 2 [n = 3] or no reaction [n = 1] at 3.3 ng/mL of alpha-gal; p = 0.03). All patients with severe grade 4 reactions had a positive CD63 BAT response to cetuximab compared to patients with moderate or no reaction, who all had negative BAT (57.7% vs. 0.9% at 500 µg/mL, 63.2% vs. 4.1% at 100 µg/mL, 58.2% vs. 2.7% at 10 µg/mL, and 32.1% vs. 3.3% at 1 µg/mL of cetuximab, respectively; p ≤ 0.001). In summary, before initiating cetuximab treatment, sIgE to alpha-gal should be assessed in all patients. To predict the severity of the reaction and to assess the risk of cetuximab-induced anaphylaxis, we should perform BATs with alpha-gal or more discriminative BATs with cetuximab.
Keywords: alpha-gal, baseline serum tryptase, basophil activation test, cetuximab, drug allergy
Published in DiRROS: 22.07.2025; Views: 588; Downloads: 266
.pdf Full text (768,48 KB)
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1500.
Modelno odločanje načrtovanja najprimernejše tehnologije pridobivanja lesa
Gašper Ogrin, Matevž Triplat, 2025, professional article

Keywords: gozdarstvo, tehnologija, pridobivanje lesa
Published in DiRROS: 22.07.2025; Views: 510; Downloads: 150
.pdf Full text (5,19 MB)

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