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282. Transcription factors gene expression in chronic rhinosinusitis with and without nasal polypsTanja Soklič, Matija Rijavec, Mira Šilar, Ana Koren, Izidor Kern, Irena Hočevar-Boltežar, Peter Korošec, 2019, original scientific article Abstract: Background. Chronic rhinosinusitis (CRS) current therapeutic approaches still fail in some patients with severe persistent symptoms and recurrences after surgery. We aimed to evaluate the master transcription factors gene expression levels of T cell subtypes in chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP) that could represent new, up-stream targets for topical DNAzyme treatment. Patients and methods. Twenty-two newly diagnosed CRS patients (14 CRSwNP and 8 CRSsNP) were prospectively biopsied and examined histopathologically. Gene expression levels of T-box transcription factor (T-bet, TBX21), GATA binding protein 3 (GATA3), Retinoic acid-related orphan receptor C (RORC) and Forkhead box P3 (FOXP3) were analyzed by real-time quantitative polymerase chain reaction (RT-qPCR). Results. Eosinophilic CRSwNP was characterized by higher level of GATA3 gene expression compared to noneosinophilic CRSwNP, whereas there was no difference in T-bet, RORC and FOXP3 between eosinophilic and noneosinophilic CRSwNP. In CRSsNP, we found simultaneous upregulation of T-bet, GATA3 and RORC gene expression levels in comparison to CRSwNP; meanwhile, there was no difference in FOXP3 gene expression between CRSwNP and CRSsNP. Conclusions. In eosinophilic CRSwNP, we confirmed the type 2 inflammation by elevated GATA3 gene expression level. In CRSsNP, we unexpectedly found simultaneous upregulation of T-bet and GATA3 that is currently unexplained; however, it might originate from activated CD8+ cells, abundant in nasal mucosa of CRSsNP patients. The elevated RORC in CRSsNP could be part of homeostatic nasal immune response that might be better preserved in CRSsNP patients compared to CRSwNP patients. Further data on transcription factors expression rates in CRS phenotypes are needed.
Keywords: sinusitis, nasal polyps, Th1 cells, Th2 cells, Th17 cells, transcription factors, chronic rhinosinusitis
Published in DiRROS: 09.10.2020; Views: 1594; Downloads: 852
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283. The Chronic Urticaria Registry (CURE) : rationale, methods, and initial implementationKarsten Weller, Ana M. Giménez-Arnau, Clive Grattan, Riccardo Asero, Pascale Mathelier-Fusade, Mojca Bizjak, Michael Hanna, Marcus Maurer, 2020, other scientific articles Abstract: Background: Chronic urticaria (CU) is a common disease, characterized by the recurrent appearance of wheals, angioedema, or both for more than 6 weeks. Its underlying biology is not well understood, and many patients do not obtain sufficient relief from recommended treatments. Patient registries are rapidly growing as a form of research, because they can provide powerful, data-driven insights about the epidemiology of diseases, real-world effectiveness of treatments, rare patient types, safety monitoring, healthcare costs, and opportunities for quality improvement of healthcare delivery. Objectives: The Chronic Urticaria Registry (CURE) has been designed to improve the scientific understanding, clinical treatment, and healthcare planning of chronic urticaria patients. This report describes the rationale, methods, and initial implementation of this registry. Methods: CURE is an ongoing, prospective, international, multicenter, observational, voluntary registry of patients with CU. Participation in CURE is open to any physician treating CU patients, regardless of location, medical specialty, or type of practice setting. CURE aims to collect data on all CU patients, with no intentional selection or exclusion criteria. It collects baseline and follow-up data on the patient's demographics, history, symptoms, trigger and risk factors, therapies, and healthcare utilization. Results: CURE is a landmark achievement of the global urticaria medical community. As of 26 February 2020, 39 centers around the world have joined the registry and 35 have entered baseline data on a total of 2946 patients. Publications of this data will be forthcoming soon. Conclusions: CURE is eagerly seeking the participation of more physicians and the support of more governmental, charitable, and commercial sponsors from around the world. Here, in this paper, we invite other physicians to join this unique project to improve the lives of patients with CU.
Keywords: urticaria, registries
Published in DiRROS: 07.10.2020; Views: 1436; Downloads: 782
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284. Priporočila za obravnavo bolnikov s pljučnim rakomMartina Vrankar, Nina Boc, Izidor Kern, Aleš Rozman, Karmen Stanič, Tomaž Štupnik, Mojca Unk, Maja Ebert Moltara, Vesna Zadnik, Katja Adamič, Jernej Benedik, Marko Bitenc, Jasna But-Hadžić, Anton Crnjac, Eva Ćirić, Tanja Čufer, Goran Gačevski, Marta Globočnik Kukovica, Kristina Gornik-Kramberger, Maja Ivanetič Pantar, Staša Jelerčič, Veronika Kloboves-Prevodnik, Mile Kovačević, Luka Ležaič, Mateja Marc-Malovrh, Katja Mohorčič, Bogdan Vidmar, Dušanka Vidovič, Gregor Vlačić, Ana Lina Vodušek, Rok Zbačnik, Ivana Žagar, 2020, professional article Keywords: pljučni rak, priporočila
Published in DiRROS: 22.09.2020; Views: 1973; Downloads: 739
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285. Poznavanje dejavnikov tveganja za nastanek raka med slovenskimi najstnikiAna Košir, Enej Hadžić, Jasna But-Hadžić, 2020, original scientific article Abstract: Uvod: Glede na trenutne trende lahko pričakujemo, da naj bi eden od dveh fantov in ena od treh deklet današnjih najstnikov do 75. leta starosti zboleli za rakom. Po podatkih državnega programa za obvladovanje raka bi lahko kar 40 % rakavih bolezni preprečili z zdravim načinom življenja in izogibanjem dejavnikom tveganja. Za to bi morali najstniki dobro poznati dejavnike tveganja, da bi v prihodnosti zmanjšali pojavnost te bolezni.
Namen: Glavni namen raziskave je bil ugotoviti, kako dobro najstniki poznajo dejavnike tveganja nastanka raka, ter preveriti, ali je razlika v znanju med spoloma ter med različno starimi najstniki. Metode dela: V raziskavo smo vključili 185 najstnikov, starih med 12 in 15 let (54 % fantov, 46 % deklet), ki so izpolnili mednarodni vprašalnik o poznavanju dejavnikov tveganja nastanka raka. Vprašalnike smo nato prenesli v elektronsko obliko s pomočjo spletnega orodja 1KA, ki nam je omogočil pripravo in tudi delno obdelavo rezultatov.
Rezultati: Najstniki na splošno dobro poznajo dejavnike tveganja za nastanek raka, saj so med najpogostejšimi 10 dejavniki pravilno opredelili 6,7 dejavnika. Fanti so imeli statistično pomembno (p = 0,026) nižjo povprečno oceno 6,44 kot dekleta, ki so imela oceno 6,95, pri čemer sta razliki nastali v oceni kajenja in telesne mase. V obeh primerih je več deklet kot fantov pravilno opredelilo ta dejavnik tveganja. 58 % učencev skrbi, da bodo zboleli za rakom, pri tem pa je med spoloma bistvena razlika, saj to skrb izraža 74 % deklet in le 44% fantov (p < 0,001). Med najpomembnejšimi dejavniki tveganja slovenski najstniki na prvem mestu navajajo kajenje (55 %), na drugem alkohol (24 %), na tretjem sevanje (14 %) in na četrtem nezdravo prehrano (14 %). Med učenci se jih 83 % strinja, da nekatera živila povečajo možnost nastanka raka. Pri vprašanju o številu potrebnih dnevnih porcij sadja in zelenjave je povprečen odgovor 3,5 porcije od priporočenih 5. Večina učencev (69 %) meni, da je rdeče meso dejavnik tveganja za nastanek raka, samo polovica pa ve, da je treba dnevno zaužiti manj kot 5 g soli. Da je vzdrževanje zdrave telesne mase eden najpomembnejših načinov preprečitve raka, se strinja 81 % učencev, 85 % pa jih meni, da je telesna dejavnost povezana s preprečevanjem nastanka raka. 87 % učencev dobro pozna nevarnost sončenja, prav tako pa dobro opredeljujejo alkohol kot dejavnik tveganja, čeprav jih 74 % ni prepričanih, ali imajo vse alkoholne pijače enak učinek.
Zaključki: Raziskava kaže na zelo dobro poznavanje dejavnikov tveganja za nastanek raka med slovenskimi najstniki. Zato menimo, da lahko današnja mladina v primerjavi s prejšnjimi generacijami doseže manjšo obolevnost za rakom ob nadaljnjem širjenju informacij o teh dejavnikih, ki temeljijo na dokazih.
Keywords: onkologija, dejavniki tveganja, najstniki, kajenje
Published in DiRROS: 09.09.2020; Views: 1874; Downloads: 557
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286. The impact of scald development on phenylpropanoid metabolism based on phenol content, enzyme activity, and gene expression analysisAnka Čebulj, Heidrun Halbwirth, Maja Mikulič Petkovšek, Robert Veberič, Ana Slatnar, 2020, original scientific article Keywords: scald, gene expression, hydroxycinnamic acids, color, enzyme activity, phenol content, scald development, apples, cold storage
Published in DiRROS: 03.09.2020; Views: 1795; Downloads: 561
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287. Odgovoren pristop do zdravja otrok: 8. strokovni posvet organizatorjev prehrane in zdravstveno-higienskega režima Slovenije: zbornik povzetkov : Terme Zreče, 19.-20. november 20182018, proceedings of professional or unreviewed scientific conference contributions Keywords: alergija, fenilketonurija, maščobe, prehrana, vitamin D, vitamin B12, prehransko programiranje, stres, mikrobiom, genotoksične snovi, naravna čistila, hormonski motilci, HACCP, uši, zdravje pri delu, javno naročanje, zborniki, povzetki
Published in DiRROS: 17.08.2020; Views: 2414; Downloads: 1002
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288. Zdravila za uporabo v paliativni mediciniJožica Červek, Mojca Simončič Godnič, Jernej Benedik, Maja Ebert Moltara, Jasenka Gugić Kevo, Slavica Lahajnar, Petra Tavčar, 2012, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: paliativna medicina, zdravila
Published in DiRROS: 10.08.2020; Views: 1943; Downloads: 547
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