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154. Standardization of PCM characterization via DSCStefan Gschwander, Thomas Haussmann, Georg Hagelstein, Aran Sole, Luisa F. Cabeza, Gonzalo Diarce, Wolfgang Hohenauer, Daniel Lager, Alenka Ristić, Christoph Rathgeber, Peter Hennemann, Harald Mehling, Conchita Peñalosa, Ana Lazaro, 2015, published scientific conference contribution Published in DiRROS: 02.12.2015; Views: 2961; Downloads: 0 |
155. Post-polymerization modification of poly(L-glutamic acid) with d-(+)-glucosaminePeter Perdih, Sašo Čebašek, Alenka Možir, Ema Žagar, 2014, original scientific article Abstract: Carboxyl functional groups of poly(L-glutamic acid) (PGlu) were modified with
a D-(+)-glucosamine (GlcN) by amidation using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-
methylmorpholinium chloride (DMTMM) as a coupling reagent. The coupling reaction
was performed in aqueous medium without protection of hydroxyl functional groups of
D-(+)-glucosamine. Poly(L-glutamic acid) and GlcN functionalized polyglutamates
(P(Glu-GlcN)) were thoroughly characterized by 1D and 2D NMR spectroscopy and
SEC-MALS to gain detailed information on their structure, composition and molar mass
characteristics. The results reveal successful functionalization with GlcN through the
amide bond and also to a minor extent through ester bond formation in position 1 of GlcN.
In addition, a ratio between the α- and β-form of glucosamine substituent coupled to
polyglutamate repeating units as well as the content of residual dimethoxy triazinyl active
ester moiety in the samples were evaluated.
Keywords: poly(L-glutamic acid), glucosamine, glycopolypeptide
Published in DiRROS: 16.12.2014; Views: 4661; Downloads: 940
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